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The map label for this gene is ilvX

Identifier: 41406651

GI number: 41406651

Start: 578392

End: 579645

Strand: Direct

Name: ilvX

Synonym: MAP0553

Alternate gene names: 41406651

Gene position: 578392-579645 (Clockwise)

Preceding gene: 41406650

Following gene: 41406658

Centisome position: 11.98

GC content: 74.08

Gene sequence:

>1254_bases
GTGAACGGTGCTCAGGCGCTGATCCGGACCCTGGTCGACGGCGGCGTCGACGTGTGTTTCGCCAACCCGGGCACGTCGGA
AATGCACTTCGTCGCGGCGCTGGACAGCGTTCCGCGGATGCGCGGCGTGCTGGCGCTGTTCGAGGGCGTGGCCACCGGCG
CGGCCGACGGGTACGCCCGCATCGCCGATCGGCCGGCCGCGGTGCTGCTGCATCTGGGCCCCGGGTTGGGCAACGGGCTG
GCCAACCTGCACAACGCCCGCCGCGCGCGGGTGCCGATGGTGGTGGTCGTCGGTGACCACGCCACCTACCACAAAAAGTA
CGACGCCCCACTGGAATCCGACATCGACGCCCTCGCCGGCAGCGTGTCGGGATGGGTGCGCCGGACCAGCGACGCCTCCC
AGGTTTCGGCCGACGCCGTCGAGGGCATCGCCGCCAGCCGGTGGGGATCGCAGATCTCCACGCTGATCCTGCCCGCCGAC
GTGTCTTGGTCCGACGGCGCGCAGCTGTTCTCCACCATGGACGCGCGGCCGGCGGGTGCCGACCCGCTGCTGGCGCCGGA
GGTGGTCGAGGTACTGCGCTCGGGGGAGCCGACGGTGATCCTGGTGGGCGGCGACGCTACCCGCCGCGCCGGGCTGGCCG
CGGCCGCCCGGATCGCCGCGGCCACCGGCGCCCGGGTGCTGTGCGAAACCTTCCCCACCCGGCTGGAGCGCGGCGCCGGC
ATCCCCGCCGTCGAGCGGCTCGCCTATTTCGCCGAAGCCGCCGCCGCCCAGCTGGACGGCGCCAAGCATCTGGTGTTGGC
CGGCGCCAAGTCGCCGGTGTCGTTCTTCGCCTACCCGGGCATGCCGAGCGATCTGGTGCCCGCCGGTTGCGAGGTGCACG
TCCTCGCCGGGCACACCGGCGCGGCGGATGCGTTGAGCGCCTTGGCGGATCAGCTCGCGCCCGGGACGGCGGCGCCGGTG
GCGGCGGCGTCGCGCCCGGCCTTGCCGACGGGCCCGCTGACGTCGGCGTCGGCGGCCGACGTGATCGGGGCGCTGCTGCC
GGAACGGGCGATCGTCGTCGACGAGTCGAACACCTCCGGCGTGCTGCTGGCACAGGCGACCGCCAGCGCGCCGGCGCACG
ACTGGCTGACCCTGACCGGCGGGGCGATCGGCTACGGCATTCCGGCCGCGGTCGGTGCCGCCGTCGCCGCCCCGGATCGT
CCGGTGCTCTGCCTGGAATCCGACGGCTCGGCGATGTACACGATCTCGGGATAG

Upstream 100 bases:

>100_bases
ACGCGCTGGCGGGACTGGACGGACTCGGGCTGTCCGACGAGGCCCGGCGGGATTTCCTGCACGGCAATGCCGAGCGGGTG
TTCAGACTGGAGGCAGCCAC

Downstream 100 bases:

>100_bases
TGGACCCAGGCCCGGGAGAACCTCAACGTGACCACCGTGCTGTACGACAACAGTGCCTACGACATCCTGCGCATCGAGCT
GCAACGCGTCGGCGCCGGAT

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNGAQALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGAADGYARIADRPAAVLLHLGPGLGNGL
ANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAGSVSGWVRRTSDASQVSADAVEGIAASRWGSQISTLILPAD
VSWSDGAQLFSTMDARPAGADPLLAPEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAG
IPAVERLAYFAEAAAAQLDGAKHLVLAGAKSPVSFFAYPGMPSDLVPAGCEVHVLAGHTGAADALSALADQLAPGTAAPV
AAASRPALPTGPLTSASAADVIGALLPERAIVVDESNTSGVLLAQATASAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDR
PVLCLESDGSAMYTISG

Sequences:

>Translated_417_residues
MNGAQALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGAADGYARIADRPAAVLLHLGPGLGNGL
ANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAGSVSGWVRRTSDASQVSADAVEGIAASRWGSQISTLILPAD
VSWSDGAQLFSTMDARPAGADPLLAPEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAG
IPAVERLAYFAEAAAAQLDGAKHLVLAGAKSPVSFFAYPGMPSDLVPAGCEVHVLAGHTGAADALSALADQLAPGTAAPV
AAASRPALPTGPLTSASAADVIGALLPERAIVVDESNTSGVLLAQATASAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDR
PVLCLESDGSAMYTISG
>Mature_417_residues
MNGAQALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGAADGYARIADRPAAVLLHLGPGLGNGL
ANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAGSVSGWVRRTSDASQVSADAVEGIAASRWGSQISTLILPAD
VSWSDGAQLFSTMDARPAGADPLLAPEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAG
IPAVERLAYFAEAAAAQLDGAKHLVLAGAKSPVSFFAYPGMPSDLVPAGCEVHVLAGHTGAADALSALADQLAPGTAAPV
AAASRPALPTGPLTSASAADVIGALLPERAIVVDESNTSGVLLAQATASAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDR
PVLCLESDGSAMYTISG

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI87081685, Length=220, Percent_Identity=30.9090909090909, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 41931; Mature: 41931

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAQALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGAADGYAR
CCHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IADRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAG
HCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
SVSGWVRRTSDASQVSADAVEGIAASRWGSQISTLILPADVSWSDGAQLFSTMDARPAGA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCC
DPLLAPEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAG
CCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
IPAVERLAYFAEAAAAQLDGAKHLVLAGAKSPVSFFAYPGMPSDLVPAGCEVHVLAGHTG
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEEEECCCC
AADALSALADQLAPGTAAPVAAASRPALPTGPLTSASAADVIGALLPERAIVVDESNTSG
HHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCC
VLLAQATASAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRPVLCLESDGSAMYTISG
EEEEECCCCCCCCCEEEEECCCHHCCCHHHHHHHHCCCCCCEEEEECCCCEEEEECC
>Mature Secondary Structure
MNGAQALIRTLVDGGVDVCFANPGTSEMHFVAALDSVPRMRGVLALFEGVATGAADGYAR
CCHHHHHHHHHHCCCCEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
IADRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDALAG
HCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHH
SVSGWVRRTSDASQVSADAVEGIAASRWGSQISTLILPADVSWSDGAQLFSTMDARPAGA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHCCCCCCC
DPLLAPEVVEVLRSGEPTVILVGGDATRRAGLAAAARIAAATGARVLCETFPTRLERGAG
CCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
IPAVERLAYFAEAAAAQLDGAKHLVLAGAKSPVSFFAYPGMPSDLVPAGCEVHVLAGHTG
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCEEEEEECCCC
AADALSALADQLAPGTAAPVAAASRPALPTGPLTSASAADVIGALLPERAIVVDESNTSG
HHHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCC
VLLAQATASAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRPVLCLESDGSAMYTISG
EEEEECCCCCCCCCEEEEECCCHHCCCHHHHHHHHCCCCCCEEEEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]