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The map label for this gene is fadE30

Identifier: 41406605

GI number: 41406605

Start: 535039

End: 536187

Strand: Direct

Name: fadE30

Synonym: MAP0507

Alternate gene names: 41406605

Gene position: 535039-536187 (Clockwise)

Preceding gene: 41406599

Following gene: 41406606

Centisome position: 11.08

GC content: 69.89

Gene sequence:

>1149_bases
ATGCAGGACGTCGAGGAGTTCCGGGCCGAGGTCCGCTCTTGGCTCGCCGACAATCTGGTCGGCGAATTCGCCGCTCTGAA
GGGCCTCGGCGGCCCCGGCCGCGAGCACGAGGCCTTCGAGGAACGCCGGGCCTGGAACCAGCACCTGGCCAAGGCCGGGC
TGACCTGCCTGGGCTGGCCGGTCGAGCACGGCGGGCGCGGGCTGTCCACCGCGCACCGGGTGGCCTTCTACGAGGAGTAC
GCCCGCGCCGACGCGCCGGACAAGGTCAACCACTTCGGCGAGGAGCTGCTCGGCCCCACGCTGATCGCGTTCGGCACCCC
CGAGCAGCAGCAGCGCTTCCTGCCCCGCATCCTCGACGTCACCGAGCTGTGGTGCCAGGGGTATTCCGAGCCCGGCGCCG
GCAGCGACCTGGCCAACGTGTCGACCACCGCCGAACTCGACGGCGACCAGTGGGTGATCAACGGCCAGAAGGTGTGGACC
TCGCTGGCGCACCTGTCGCAGTGGTGCTTCGTGGTCGCGCGCACCGAGAAGGGCTCCAAGCGGCACGCCGGGCTGTCGTA
TCTGCTGGTGCCGCTGGACCAGCCGGGGGTGCAGATCCGGCCCATCGTGCAGATCACCGGCACCGCGGAGTTCAACGAGG
TGTTCTTCGACGACGCCCGCACCGACGCGTCGATGGTGGTCGGCCAGCCCGGCGACGGCTGGCGGGTCGCCATGGGAACG
CTGACCTTCGAGCGCGGCGTGTCCACGCTCGGGCAGCAGATCCGTTACGCGCGTGAGCTTTCCAACCTGGCCGAGCTCGC
GCGGCGCAACGGCGCCGCCGACGACCCGTTCATCCGGGAGCGGCTGACCCGCGCCTGGACCGGGCTGCGCGCGATGCGGT
CGTATGCCCTGGCCACCATGGACGTCGAGCAGCCCGGGCAGGACAACGTGTCGAAGTTGTTGTGGGCCAACTGGCATCGG
GCTCTCGGCGAGCTGGCCATGGACGTCATCGGCAAGCCCGGCATGACCATGCCCGACGGCGAATTCGACGAGTGGCAGCG
GTTGTTCCTGTTCACCCGCGCCGACACCATCTACGGCGGCTCCAACGAGATCCAGCGCAACATCATCGCCGAGCGGGTGC
TCGGCCTGCCCCGGGAGGTAAAGGGATGA

Upstream 100 bases:

>100_bases
CGATCCAGCGCCGCGGGCACGGTGCGGGGATCGGTGGTCACGGCGGCGCTCCTCGAATGCCTGTAACAAAGCAAGTGCTT
GGTAGGTTAGCCTACAAGGC

Downstream 100 bases:

>100_bases
GCCTGTCCGAAGCTCCGAAAGAGATTGCGGGACACGGGCTTCTGGAAGGCAAGGTGGTGATCGTCACCGCGGCGGCCGGC
ACGGGTATCGGCTCGGCGAC

Product: FadE30

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGREHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEY
ARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPGAGSDLANVSTTAELDGDQWVINGQKVWT
SLAHLSQWCFVVARTEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDASMVVGQPGDGWRVAMGT
LTFERGVSTLGQQIRYARELSNLAELARRNGAADDPFIRERLTRAWTGLRAMRSYALATMDVEQPGQDNVSKLLWANWHR
ALGELAMDVIGKPGMTMPDGEFDEWQRLFLFTRADTIYGGSNEIQRNIIAERVLGLPREVKG

Sequences:

>Translated_382_residues
MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGREHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEY
ARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPGAGSDLANVSTTAELDGDQWVINGQKVWT
SLAHLSQWCFVVARTEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDASMVVGQPGDGWRVAMGT
LTFERGVSTLGQQIRYARELSNLAELARRNGAADDPFIRERLTRAWTGLRAMRSYALATMDVEQPGQDNVSKLLWANWHR
ALGELAMDVIGKPGMTMPDGEFDEWQRLFLFTRADTIYGGSNEIQRNIIAERVLGLPREVKG
>Mature_382_residues
MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGREHEAFEERRAWNQHLAKAGLTCLGWPVEHGGRGLSTAHRVAFYEEY
ARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDVTELWCQGYSEPGAGSDLANVSTTAELDGDQWVINGQKVWT
SLAHLSQWCFVVARTEKGSKRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDASMVVGQPGDGWRVAMGT
LTFERGVSTLGQQIRYARELSNLAELARRNGAADDPFIRERLTRAWTGLRAMRSYALATMDVEQPGQDNVSKLLWANWHR
ALGELAMDVIGKPGMTMPDGEFDEWQRLFLFTRADTIYGGSNEIQRNIIAERVLGLPREVKG

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=340, Percent_Identity=28.8235294117647, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=25.2631578947368, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=25.2631578947368, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501857, Length=386, Percent_Identity=25.3886010362694, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4501859, Length=353, Percent_Identity=28.0453257790368, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI226958412, Length=218, Percent_Identity=27.0642201834862, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI226958414, Length=212, Percent_Identity=26.4150943396226, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=26.2108262108262, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI48976061, Length=173, Percent_Identity=31.2138728323699, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI211971008, Length=173, Percent_Identity=31.2138728323699, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI38505218, Length=180, Percent_Identity=30.5555555555556, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7656849, Length=324, Percent_Identity=24.0740740740741, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI76496475, Length=356, Percent_Identity=23.876404494382, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557235, Length=356, Percent_Identity=23.876404494382, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786223, Length=346, Percent_Identity=23.4104046242775, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081958, Length=351, Percent_Identity=24.5014245014245, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=392, Percent_Identity=27.2959183673469, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17534899, Length=335, Percent_Identity=25.9701492537313, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17508101, Length=348, Percent_Identity=27.8735632183908, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17569725, Length=338, Percent_Identity=25.1479289940828, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=343, Percent_Identity=25.6559766763848, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17538396, Length=345, Percent_Identity=24.9275362318841, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17505929, Length=343, Percent_Identity=25.6559766763848, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=201, Percent_Identity=30.3482587064677, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI32563615, Length=187, Percent_Identity=31.0160427807487, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990804, Length=192, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=211, Percent_Identity=27.0142180094787, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=27.0777479892761, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356377, Length=357, Percent_Identity=27.1708683473389, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24660351, Length=302, Percent_Identity=28.1456953642384, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281363737, Length=346, Percent_Identity=26.0115606936416, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21355753, Length=273, Percent_Identity=25.6410256410256, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24666513, Length=197, Percent_Identity=26.9035532994924, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 42583; Mature: 42583

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGREHEAFEERRAWNQHLAKAGLTCLGWP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCC
VEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDV
HHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
TELWCQGYSEPGAGSDLANVSTTAELDGDQWVINGQKVWTSLAHLSQWCFVVARTEKGSK
HHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECHHHHHHHHHHHHHHHEEEEECCCCCC
RHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDASMVVGQPGDGWRVAMGT
HHCCCEEEEEECCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCEEEEEH
LTFERGVSTLGQQIRYARELSNLAELARRNGAADDPFIRERLTRAWTGLRAMRSYALATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
DVEQPGQDNVSKLLWANWHRALGELAMDVIGKPGMTMPDGEFDEWQRLFLFTRADTIYGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEECCCEECC
SNEIQRNIIAERVLGLPREVKG
HHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MQDVEEFRAEVRSWLADNLVGEFAALKGLGGPGREHEAFEERRAWNQHLAKAGLTCLGWP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCC
VEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAFGTPEQQQRFLPRILDV
HHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHH
TELWCQGYSEPGAGSDLANVSTTAELDGDQWVINGQKVWTSLAHLSQWCFVVARTEKGSK
HHHHHCCCCCCCCCCCCCCCCCEEEECCCEEEECHHHHHHHHHHHHHHHEEEEECCCCCC
RHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDASMVVGQPGDGWRVAMGT
HHCCCEEEEEECCCCCCEEEEEEEEECCCHHHHHHHCCCCCCCEEEECCCCCCCEEEEEH
LTFERGVSTLGQQIRYARELSNLAELARRNGAADDPFIRERLTRAWTGLRAMRSYALATM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEE
DVEQPGQDNVSKLLWANWHRALGELAMDVIGKPGMTMPDGEFDEWQRLFLFTRADTIYGG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHEECCCEECC
SNEIQRNIIAERVLGLPREVKG
HHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]