Click here to switch to the map view.

The map label for this gene is folE

Identifier: 41406547

GI number: 41406547

Start: 478293

End: 478907

Strand: Direct

Name: folE

Synonym: MAP0449

Alternate gene names: 41406547

Gene position: 478293-478907 (Clockwise)

Preceding gene: 41406546

Following gene: 41406548

Centisome position: 9.9

GC content: 68.29

Gene sequence:

>615_bases
ATGGCCGGGAACGGTTCAGCGCCGGACACCGCGACGCACCAGGTCCGGCAGTTCGACCAGGCGCGCGCCGAGGCCGCCGT
CCGCGAGTTGCTGTTCGCCATCGGCGAGGACCCCGACCGGCACGGCCTGGCCGAAACCCCGGCCCGCGTCGCCCGCGCCT
ACCGGGAGATGTTCGCCGGCCTGTACACCGACCCGGACAGCGTGCTGAACACCATGTTCGACGAGGAACACGACGAACTG
GTGCTGGTCAAGGAGATCCCGCTGTACTCCACCTGCGAGCACCACCTGGTGTCGTTTCACGGGGTGGCCCATGTCGGTTA
CATCCCCGGCAACGACGGCCGGGTCACCGGCCTGTCCAAGATCGCCCGCCTGGTCGACCTGTACGCCAAGCGGCCCCAGG
TGCAGGAGCGGCTGACCAGTCAGATCGCCGACGCCCTGGTGAAAAAGCTCAATCCGCGCGGGGTGATCGTGGTGGTCGAG
GCCGAGCATCTGTGCATGGCGATGCGCGGTGTCCGCAAACCCGGTGCCGTCACCACGACGTCGGCGGTGCGCGGGCTGTT
CAAGACCAACGCGGCTTCTCGGGCGGAGGCGCTCGACCTGATCCTGCGTAAGTGA

Upstream 100 bases:

>100_bases
CCCGGTCAGCCCGCCCCCGAGGGTGGGTCGCCGGACCGGCAGGATGACGACGTGAGCCGGTCCAACCCGCCGGCCCACGG
CTGAGCAAACGGAGGATGTG

Downstream 100 bases:

>100_bases
GTCCGGCGCCTTGCAGGTAATGGGAGTCTTGAACGTCACTGACGATTCGTTCTCCGACGGTGGCCGCTACCTCGACCCCG
ACAAGGCCGTCGCACACGGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MAGNGSAPDTATHQVRQFDQARAEAAVRELLFAIGEDPDRHGLAETPARVARAYREMFAGLYTDPDSVLNTMFDEEHDEL
VLVKEIPLYSTCEHHLVSFHGVAHVGYIPGNDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVKKLNPRGVIVVVE
AEHLCMAMRGVRKPGAVTTTSAVRGLFKTNAASRAEALDLILRK

Sequences:

>Translated_204_residues
MAGNGSAPDTATHQVRQFDQARAEAAVRELLFAIGEDPDRHGLAETPARVARAYREMFAGLYTDPDSVLNTMFDEEHDEL
VLVKEIPLYSTCEHHLVSFHGVAHVGYIPGNDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVKKLNPRGVIVVVE
AEHLCMAMRGVRKPGAVTTTSAVRGLFKTNAASRAEALDLILRK
>Mature_203_residues
AGNGSAPDTATHQVRQFDQARAEAAVRELLFAIGEDPDRHGLAETPARVARAYREMFAGLYTDPDSVLNTMFDEEHDELV
LVKEIPLYSTCEHHLVSFHGVAHVGYIPGNDGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVKKLNPRGVIVVVEA
EHLCMAMRGVRKPGAVTTTSAVRGLFKTNAASRAEALDLILRK

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=178, Percent_Identity=50, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI4503949, Length=178, Percent_Identity=50, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI66932970, Length=138, Percent_Identity=51.4492753623188, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI66932972, Length=138, Percent_Identity=51.4492753623188, Blast_Score=136, Evalue=1e-32,
Organism=Escherichia coli, GI1788476, Length=172, Percent_Identity=43.0232558139535, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=180, Percent_Identity=48.8888888888889, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6321706, Length=185, Percent_Identity=48.1081081081081, Blast_Score=171, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24656796, Length=223, Percent_Identity=43.0493273542601, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24656782, Length=187, Percent_Identity=47.5935828877005, Blast_Score=163, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24656791, Length=187, Percent_Identity=47.5935828877005, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 22354; Mature: 22223

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGNGSAPDTATHQVRQFDQARAEAAVRELLFAIGEDPDRHGLAETPARVARAYREMFAG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LYTDPDSVLNTMFDEEHDELVLVKEIPLYSTCEHHLVSFHGVAHVGYIPGNDGRVTGLSK
CCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHH
IARLVDLYAKRPQVQERLTSQIADALVKKLNPRGVIVVVEAEHLCMAMRGVRKPGAVTTT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCHHH
SAVRGLFKTNAASRAEALDLILRK
HHHHHHHHHCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGNGSAPDTATHQVRQFDQARAEAAVRELLFAIGEDPDRHGLAETPARVARAYREMFAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
LYTDPDSVLNTMFDEEHDELVLVKEIPLYSTCEHHLVSFHGVAHVGYIPGNDGRVTGLSK
CCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCHHEEEEECCCCCCCHHHHH
IARLVDLYAKRPQVQERLTSQIADALVKKLNPRGVIVVVEAEHLCMAMRGVRKPGAVTTT
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHCCCCCCCHHH
SAVRGLFKTNAASRAEALDLILRK
HHHHHHHHHCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA