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The map label for this gene is ethA [H]

Identifier: 41406278

GI number: 41406278

Start: 187161

End: 188630

Strand: Direct

Name: ethA [H]

Synonym: MAP0180

Alternate gene names: 41406278

Gene position: 187161-188630 (Clockwise)

Preceding gene: 41406275

Following gene: 41406287

Centisome position: 3.88

GC content: 66.39

Gene sequence:

>1470_bases
ATGACTGAACACCTTGACGTCCTCATCGTGGGCGCCGGAATCTCCGGCGTGAGTGCCGCCTGGCACCTGCAGAACCGCTG
CCCCACCAAGAGCTACGCCATCCTGGAACGCCGCGCCGACCTGGGCGGCACCTGGGACCTGTTCAAGTACCCGGGCATCC
GGTCCGACTCCGACATGTTCACGCTCGGCTTCCGCTTCAAGCCGTGGCGGTCGGCGAAGTCGATCGCCGACGGCGCGTCG
ATCAAGGCCTACATCAAGGAGGCCGCGGTCGAGAACCGGATCGAGCCGCACATCCGCTACCGGCACCGGGTGGTGGCCGC
CGACTGGTCCGATGCCGACAACCGCTGGACGGTGACCGTGGAGCACGACGGCCAGCGCAGCGAGATCACCTGCTCGTTCC
TGTTCGCCTGCACCGGCTACTACAACTACGACGAGGGCTACTCGCCCACCTTCCCCGGGGCCGAGGATTTCGGCGGCACC
ATCGTCCACCCGCAGCACTGGCCCGAGGACCTCGACTATGCGAGCAAGCGCATCGTGGTCATCGGCTCCGGCGCCACCGC
GATCACCCTGATCCCGGCCCTGGTGAACTCCGGCGCCGGGCATGTGACGATGCTGCAGCGCTCGCCGACCTACATCGGCT
CGCTGCCCGGGGTCGACCCGTTCGCCGAGCGGGCCAACCGGCTGCTGCCCGACCGGCTGGCGCACATGGCCAACCGCTGG
AAAGCCATCGCGTTCAGCACCTTCCAGTACCAGCTGTCCCGCAAGGCCCCGGCTTACATGCGCAAGACGCTGATGACGAT
GGCCAAGCGCCGCCTGCCCGAGGGCTACGACGTGGAAAAGCACTTCGGGCCGCGCTACAACGTGTGGGACGAGCGGCTGT
GCCTGGCCCCCGACGGCGACTTCTTCCGCACCATCCGGCACGGCAAGGCCGACGTCGTCACTGACACCATCGACCGGTTC
ACCACGACCGGCATCAGGCTGAACTCCGGCGAGGAACTGCCGGCCGACATCATCGTCACCGCAACGGGATTGAACATGCA
GCTGCTCGGTGGGGTGACGCCGACCCGCAACGGCGAGCCGGTCGACCTGACGTCGCTGATGACCTACAAGGGGCTGATGT
TCTCCGGGATGCCGAACTTCGCCATCACGTTCGGCTACACCAACGCATCGTGGACGCTGAAGGCCGACCTGGTCTCCGAA
TTCGTCTGCCGGCTGCTGAACTACATGGACGCCAAGGGGTTTGACTTCGTGGAGCCGCAGCACCCGGGCGAGGACGTCGA
CGAGCTGCCGTTCATGGACTTCACTCCGGGCTACTTCCGCCGGTCGATGCACCTGCTGCCCAAGTCTGGGTCGCGGGCCC
CGTGGCGGCTCAAGCAGAACTACTTCTTCGACATGCGGACCATCCGGCGCGGCCGGGTCGACGATGAGGGCCTGAAGTTC
GCGAAAAAGCGTGCGCCGGTAGCGGTTTAG

Upstream 100 bases:

>100_bases
CGCGTCTGGCCGGCGGTAGTCACGGCCGCTACTTTACACGCCGTCGATAAATTCGACAGGGTGTTGACCGCTTCGACACG
GTGTTGATAGCGTGGTTTTC

Downstream 100 bases:

>100_bases
TCTCCTACAGCGACGACGATCCCGTCGTCGTCGCTGTAGGCGATGTCGCCGGGCGTGAACGTCACACCGCCGAGGGTGAT
GTCGACGTCGCGCTCGCCGG

Product: hypothetical protein

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MTEHLDVLIVGAGISGVSAAWHLQNRCPTKSYAILERRADLGGTWDLFKYPGIRSDSDMFTLGFRFKPWRSAKSIADGAS
IKAYIKEAAVENRIEPHIRYRHRVVAADWSDADNRWTVTVEHDGQRSEITCSFLFACTGYYNYDEGYSPTFPGAEDFGGT
IVHPQHWPEDLDYASKRIVVIGSGATAITLIPALVNSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRW
KAIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCLAPDGDFFRTIRHGKADVVTDTIDRF
TTTGIRLNSGEELPADIIVTATGLNMQLLGGVTPTRNGEPVDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKADLVSE
FVCRLLNYMDAKGFDFVEPQHPGEDVDELPFMDFTPGYFRRSMHLLPKSGSRAPWRLKQNYFFDMRTIRRGRVDDEGLKF
AKKRAPVAV

Sequences:

>Translated_489_residues
MTEHLDVLIVGAGISGVSAAWHLQNRCPTKSYAILERRADLGGTWDLFKYPGIRSDSDMFTLGFRFKPWRSAKSIADGAS
IKAYIKEAAVENRIEPHIRYRHRVVAADWSDADNRWTVTVEHDGQRSEITCSFLFACTGYYNYDEGYSPTFPGAEDFGGT
IVHPQHWPEDLDYASKRIVVIGSGATAITLIPALVNSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRW
KAIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCLAPDGDFFRTIRHGKADVVTDTIDRF
TTTGIRLNSGEELPADIIVTATGLNMQLLGGVTPTRNGEPVDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKADLVSE
FVCRLLNYMDAKGFDFVEPQHPGEDVDELPFMDFTPGYFRRSMHLLPKSGSRAPWRLKQNYFFDMRTIRRGRVDDEGLKF
AKKRAPVAV
>Mature_488_residues
TEHLDVLIVGAGISGVSAAWHLQNRCPTKSYAILERRADLGGTWDLFKYPGIRSDSDMFTLGFRFKPWRSAKSIADGASI
KAYIKEAAVENRIEPHIRYRHRVVAADWSDADNRWTVTVEHDGQRSEITCSFLFACTGYYNYDEGYSPTFPGAEDFGGTI
VHPQHWPEDLDYASKRIVVIGSGATAITLIPALVNSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRWK
AIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCLAPDGDFFRTIRHGKADVVTDTIDRFT
TTGIRLNSGEELPADIIVTATGLNMQLLGGVTPTRNGEPVDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKADLVSEF
VCRLLNYMDAKGFDFVEPQHPGEDVDELPFMDFTPGYFRRSMHLLPKSGSRAPWRLKQNYFFDMRTIRRGRVDDEGLKFA
KKRAPVAV

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 55132; Mature: 55001

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHLDVLIVGAGISGVSAAWHLQNRCPTKSYAILERRADLGGTWDLFKYPGIRSDSDMF
CCCCEEEEEEECCCCCCHHHEEHHCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEE
TLGFRFKPWRSAKSIADGASIKAYIKEAAVENRIEPHIRYRHRVVAADWSDADNRWTVTV
EEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEEEE
EHDGQRSEITCSFLFACTGYYNYDEGYSPTFPGAEDFGGTIVHPQHWPEDLDYASKRIVV
ECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEECCCCCCCHHHHCCCEEEE
IGSGATAITLIPALVNSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRW
EECCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHC
KAIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCLAPDGD
EEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECCCCH
FFRTIRHGKADVVTDTIDRFTTTGIRLNSGEELPADIIVTATGLNMQLLGGVTPTRNGEP
HHHHHHCCCCHHHHHHHHHHEECCEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCC
VDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKADLVSEFVCRLLNYMDAKGFDFVEPQ
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC
HPGEDVDELPFMDFTPGYFRRSMHLLPKSGSRAPWRLKQNYFFDMRTIRRGRVDDEGLKF
CCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCEEEEHHHHHCCCCCHHHHHH
AKKRAPVAV
HHHCCCCCC
>Mature Secondary Structure 
TEHLDVLIVGAGISGVSAAWHLQNRCPTKSYAILERRADLGGTWDLFKYPGIRSDSDMF
CCCEEEEEEECCCCCCHHHEEHHCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCEE
TLGFRFKPWRSAKSIADGASIKAYIKEAAVENRIEPHIRYRHRVVAADWSDADNRWTVTV
EEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCEEEEEE
EHDGQRSEITCSFLFACTGYYNYDEGYSPTFPGAEDFGGTIVHPQHWPEDLDYASKRIVV
ECCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCHHHCCCEEECCCCCCCHHHHCCCEEEE
IGSGATAITLIPALVNSGAGHVTMLQRSPTYIGSLPGVDPFAERANRLLPDRLAHMANRW
EECCCHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCHHHHHHHCCCHHHHHHHHHHC
KAIAFSTFQYQLSRKAPAYMRKTLMTMAKRRLPEGYDVEKHFGPRYNVWDERLCLAPDGD
EEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCEEEECCCCH
FFRTIRHGKADVVTDTIDRFTTTGIRLNSGEELPADIIVTATGLNMQLLGGVTPTRNGEP
HHHHHHCCCCHHHHHHHHHHEECCEEECCCCCCCCEEEEEECCCCEEEECCCCCCCCCCC
VDLTSLMTYKGLMFSGMPNFAITFGYTNASWTLKADLVSEFVCRLLNYMDAKGFDFVEPQ
CCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCC
HPGEDVDELPFMDFTPGYFRRSMHLLPKSGSRAPWRLKQNYFFDMRTIRRGRVDDEGLKF
CCCCCHHHCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCCEEEEHHHHHCCCCCHHHHHH
AKKRAPVAV
HHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA