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The map label for this gene is prrB [H]

Identifier: 41406251

GI number: 41406251

Start: 156382

End: 157710

Strand: Direct

Name: prrB [H]

Synonym: MAP0153

Alternate gene names: 41406251

Gene position: 156382-157710 (Clockwise)

Preceding gene: 41406244

Following gene: 41406252

Centisome position: 3.24

GC content: 69.68

Gene sequence:

>1329_bases
ATGCGGGTGCTGTCGCTGCGCACCATCGTCATCGTGGCCGCGATCTCGGTGATGACCCTGGTCGTCCTGCTGGGCACATG
GGTGTGGGTGGGCGTCACCAACGACCAGTACAACCAGCTGGACCGCCGGCTCGATTCGGTCAGCAGCCTGGGCGACATCA
GCAGCCTGCTCACCAACCCGCAGCACAACAGCCCGGACCGCGCCACCCCGGACGGCAACCTGGTGCGCACCGCGCGCATC
GGCGGCGTGACCGTGTCGGTGCCGAGCAACATCGTGTTGCCGCAACTTCCCGACGGTTACGCCAACACCACGATCAACGG
GGTGCAGTACCGCGTCCGCACCTTCACCGCGGGCCCCGCCTCGATCGCGCTCGCCGCGCCGCTGGCCGAAGCCCAGCACC
GGATCAACGAACTGCACCTGCGGGTGTTGTTGATCTGCGCCAGCGTGATCGGCGGTACGGTGGTGGTGGGCTGGGTGATC
TCGTTGATCATGGTCAATCCGTTCCTGCTGCTGGCCCAGCAGGCGCGCGCGATCAACGCCCAGTCCAGCCCGGACGAGGT
CCAGGTGCGCGGCGTGCGCGAGGCCGTCGAGATCGCCGAGGCGGTCGAGGGCATGCTGGCCCGCATCGGCAAGGAACAGC
AGCGCACCAAGGCCGCGCTCGAGTCGGCCCGCGACTTCGCGGCCGTCGCCTCCCACGAGCTGCGCACGCCGCTGACCGCC
ATGCGCACAAACCTGGAGGTGCTGTCCACCCTGGACCTGCCGCACGAGCAGCGCCAGGAGGTGATCGGCGACGTCATCCG
CACCCAGAGCCGCATCGAGGCCACGCTGACCGCGCTGGAGCGGCTGGCCCAGGGCGAGCTGACCACCGTCGACGATTTCG
TCCCGTTCGACATCACCGAACTGCTGGACCGCGCCGCCCACGACGCCCTGCGCGTCTACCCCGACGTGGAGGTGTCGCTG
GTGCCCTCGCCGACGGTGCTGATGATCGGGCTGCCCACCGGGCTGCGGCTGGTGATCGACAACGCCATCGCCAACGCCGT
CAAGCACGGCAACGCCGGCAAGATCCAGCTCACCGTCAGCAGCTCCGGTGAGGGCGTGGAGATCGCCATCGACGACGACG
GCAGCGGGATTCCGGAGTCCGAGCGCGCCACCGTGTTCGAACGTTTCGCCCGCGGGTCGACGGCGGCGCGCTCGGGTTCC
GGGCTGGGCCTGGCGTTGGTGGCTCAGCAGGCCGAATTACACGGCGGCACAGCCGAATTGCAGAACAGCCCGCTGGGCGG
TACCCGGCTGCTGCTGCGGCTCGCCGGAGACGGGCGCGGACCGGCGTAG

Upstream 100 bases:

>100_bases
CGCTCGGCGCGCGAGGGGGAGAAGGCGATGCGGTTAGCGTTAGATTCTTGCCGAACTGAAGGAGCCTGACATTCGCGTCT
TACCGCGCATACAGCTGCCG

Downstream 100 bases:

>100_bases
CGGGCCGATCGAAGACAGGGCACTCGACGTCAAGCCACGCGCCCTTGTGTTAGTAGAGCGATCTATATAATCTGATGCCC
GGGGGCAGCGGATCCGAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MRVLSLRTIVIVAAISVMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNPQHNSPDRATPDGNLVRTARI
GGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTFTAGPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVI
SLIMVNPFLLLAQQARAINAQSSPDEVQVRGVREAVEIAEAVEGMLARIGKEQQRTKAALESARDFAAVASHELRTPLTA
MRTNLEVLSTLDLPHEQRQEVIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITELLDRAAHDALRVYPDVEVSL
VPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVSSSGEGVEIAIDDDGSGIPESERATVFERFARGSTAARSGS
GLGLALVAQQAELHGGTAELQNSPLGGTRLLLRLAGDGRGPA

Sequences:

>Translated_442_residues
MRVLSLRTIVIVAAISVMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNPQHNSPDRATPDGNLVRTARI
GGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTFTAGPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVI
SLIMVNPFLLLAQQARAINAQSSPDEVQVRGVREAVEIAEAVEGMLARIGKEQQRTKAALESARDFAAVASHELRTPLTA
MRTNLEVLSTLDLPHEQRQEVIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITELLDRAAHDALRVYPDVEVSL
VPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVSSSGEGVEIAIDDDGSGIPESERATVFERFARGSTAARSGS
GLGLALVAQQAELHGGTAELQNSPLGGTRLLLRLAGDGRGPA
>Mature_442_residues
MRVLSLRTIVIVAAISVMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNPQHNSPDRATPDGNLVRTARI
GGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTFTAGPASIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVI
SLIMVNPFLLLAQQARAINAQSSPDEVQVRGVREAVEIAEAVEGMLARIGKEQQRTKAALESARDFAAVASHELRTPLTA
MRTNLEVLSTLDLPHEQRQEVIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITELLDRAAHDALRVYPDVEVSL
VPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVSSSGEGVEIAIDDDGSGIPESERATVFERFARGSTAARSGS
GLGLALVAQQAELHGGTAELQNSPLGGTRLLLRLAGDGRGPA

Specific function: Member of the two-component regulatory system prrB/prrA. Involved specifically in early intracellular multiplication of Mycobacterium. Probably phosphorylates prrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=30.0411522633745, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=243, Percent_Identity=27.9835390946502, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=309, Percent_Identity=26.2135922330097, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790861, Length=297, Percent_Identity=26.2626262626263, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790551, Length=241, Percent_Identity=26.9709543568465, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789403, Length=259, Percent_Identity=28.1853281853282, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788713, Length=266, Percent_Identity=24.812030075188, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789149, Length=268, Percent_Identity=28.3582089552239, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=211, Percent_Identity=32.7014218009479, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788279, Length=322, Percent_Identity=25.776397515528, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=205, Percent_Identity=32.6829268292683, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=27.8884462151394, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1787374, Length=275, Percent_Identity=24.7272727272727, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87081816, Length=242, Percent_Identity=28.5123966942149, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786600, Length=228, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47014; Mature: 47014

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLSLRTIVIVAAISVMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNP
CCEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
QHNSPDRATPDGNLVRTARIGGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTFTAGPA
CCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
SIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVISLIMVNPFLLLAQQARAINA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QSSPDEVQVRGVREAVEIAEAVEGMLARIGKEQQRTKAALESARDFAAVASHELRTPLTA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MRTNLEVLSTLDLPHEQRQEVIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LLDRAAHDALRVYPDVEVSLVPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVS
HHHHHHHHHHEECCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
SSGEGVEIAIDDDGSGIPESERATVFERFARGSTAARSGSGLGLALVAQQAELHGGTAEL
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCCHHHH
QNSPLGGTRLLLRLAGDGRGPA
CCCCCCHHHEEEEEECCCCCCC
>Mature Secondary Structure
MRVLSLRTIVIVAAISVMTLVVLLGTWVWVGVTNDQYNQLDRRLDSVSSLGDISSLLTNP
CCEEHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCC
QHNSPDRATPDGNLVRTARIGGVTVSVPSNIVLPQLPDGYANTTINGVQYRVRTFTAGPA
CCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCC
SIALAAPLAEAQHRINELHLRVLLICASVIGGTVVVGWVISLIMVNPFLLLAQQARAINA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QSSPDEVQVRGVREAVEIAEAVEGMLARIGKEQQRTKAALESARDFAAVASHELRTPLTA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MRTNLEVLSTLDLPHEQRQEVIGDVIRTQSRIEATLTALERLAQGELTTVDDFVPFDITE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LLDRAAHDALRVYPDVEVSLVPSPTVLMIGLPTGLRLVIDNAIANAVKHGNAGKIQLTVS
HHHHHHHHHHEECCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEEE
SSGEGVEIAIDDDGSGIPESERATVFERFARGSTAARSGSGLGLALVAQQAELHGGTAEL
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHHHHCCCHHHH
QNSPLGGTRLLLRLAGDGRGPA
CCCCCCHHHEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]