Click here to switch to the map view.

The map label for this gene is cmaA1

Identifier: 41406233

GI number: 41406233

Start: 143027

End: 143911

Strand: Direct

Name: cmaA1

Synonym: MAP0135

Alternate gene names: 41406233

Gene position: 143027-143911 (Clockwise)

Preceding gene: 41406228

Following gene: 41406234

Centisome position: 2.96

GC content: 65.54

Gene sequence:

>885_bases
TTGTCCGAGAACACCGGCGATGCCGTCAACTTGCAACCGCATTTCGACGACGTCCAAGCGCACTACGACCTGTCCGACGA
GTTCTTCGCGCTGTTCCTGGACCCGACCCGGACCTACAGCTGCGCGTATTTCGAGCGGGACGACATGACGCTGGAAGAGG
CGCAGATCGCCAAGGTCGACCTGTCGCTGGGCAAGCTGGGATTACAGCCGGGCATGACCTTGCTCGACATCGGCTGCGGC
TGGGGCACCACAATCGTGCGCGCGCTGGAGCGCTACGACGTCAACGTCGTCGGCCTCACGCTGAGCCGCAACCAGCAGGC
GCACGTGCAGCGCCGGCTGGACAACCATCCGTCCCCGCGCAGCAAGCGGGTGCTGCTGCAGGGCTGGGAGCAGTTCGACG
AGAAGGTCGACCGCATCGTGTCGATCGGTGCCTTCGAGCATTTCGGCCGCGACCGCTACGACGACTTCTTCAAGATGGCC
TACGCGGCGCTCCCGGACGACGGCGTGATGCTGCTGCACACCATCATCAAGCCCAGCGACGAGGAGTTCGCCGAGCGCGG
CCTGCCCATCACCATGACCAAGCTGCGCTTCATGAAATTCATCATGGACGAGATCTTCCCGGGTGGAGACCTGCCCCAGG
CCAAGGGCGTCATCGAGCACGCGCAGCGGGCCGGCTTCGGTGTGCAGCGGGTGCAGGCGCTGCGCCCGCACTACGCCCGC
ACCCTGGACACCTGGGCCGCCGCGCTGCGGGCGCGCCGCGACGAGGCCATTGCGATCCAGTCCGAAGAGGTCTACGACCG
CTACATGAAGTACCTGACGGGTTGCGCGGACCTGTTCCGTGAGGGCTACACCGACGTCGCGCAATTCACCCTGACCAAGG
GCTGA

Upstream 100 bases:

>100_bases
CCGGGGGCCGCCGACGCGGCGGATACACTGAGGCAGCCGCGAGGCGACCGGCCACGGTCGCGCCCGTCAAACCCGATCAG
AATAAGTCAGAGGTTGTGCC

Downstream 100 bases:

>100_bases
CGTCGGGCCTGCGCCCGGCGCGGTTTACCGGCGCATTCCGGTAGGTAACTCCACGGCAATACCCCAATCCCCGCTTTGCG
CAGCGTATTTCACGGTCAAC

Product: CmaA1

Products: NA

Alternate protein names: CMAS; Cyclopropane-fatty-acyl-phospholipid synthase; CFA synthase; Cyclopropane fatty acid synthase; Mycolic acid methyltransferase; MA-MT; S-adenosylmethionine-dependent methyltransferase; AdoMet-MT; SAM-MT [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMTLEEAQIAKVDLSLGKLGLQPGMTLLDIGCG
WGTTIVRALERYDVNVVGLTLSRNQQAHVQRRLDNHPSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYDDFFKMA
YAALPDDGVMLLHTIIKPSDEEFAERGLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYAR
TLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG

Sequences:

>Translated_294_residues
MSENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMTLEEAQIAKVDLSLGKLGLQPGMTLLDIGCG
WGTTIVRALERYDVNVVGLTLSRNQQAHVQRRLDNHPSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYDDFFKMA
YAALPDDGVMLLHTIIKPSDEEFAERGLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYAR
TLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
>Mature_293_residues
SENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMTLEEAQIAKVDLSLGKLGLQPGMTLLDIGCGW
GTTIVRALERYDVNVVGLTLSRNQQAHVQRRLDNHPSPRSKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYDDFFKMAY
AALPDDGVMLLHTIIKPSDEEFAERGLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYART
LDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG

Specific function: Catalyzes the conversion of a double bond to a cyclopropane ring at the distal position of an alpha mycolic acid via the transfers of a methylene group from S-adenosyl-L- methionine. Cyclopropanated mycolic acids are key factors participating in cell enve

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CFA/CMAS family [H]

Homologues:

Organism=Escherichia coli, GI1787951, Length=276, Percent_Identity=34.4202898550725, Blast_Score=149, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI133904226, Length=286, Percent_Identity=30.4195804195804, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003333 [H]

Pfam domain/function: PF02353 CMAS [H]

EC number: =2.1.1.79 [H]

Molecular weight: Translated: 33529; Mature: 33398

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMTLEEAQIAKVD
CCCCCCCEEECCCCCCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHH
LSLGKLGLQPGMTLLDIGCGWGTTIVRALERYDVNVVGLTLSRNQQAHVQRRLDNHPSPR
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCC
SKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYDDFFKMAYAALPDDGVMLLHTIIKPSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCH
EEFAERGLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYAR
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCC
>Mature Secondary Structure 
SENTGDAVNLQPHFDDVQAHYDLSDEFFALFLDPTRTYSCAYFERDDMTLEEAQIAKVD
CCCCCCEEECCCCCCCHHHHCCCCCCEEEEEECCCCCEEEEEEECCCCCHHHHHHHHHH
LSLGKLGLQPGMTLLDIGCGWGTTIVRALERYDVNVVGLTLSRNQQAHVQRRLDNHPSPR
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCCCC
SKRVLLQGWEQFDEKVDRIVSIGAFEHFGRDRYDDFFKMAYAALPDDGVMLLHTIIKPSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCH
EEFAERGLPITMTKLRFMKFIMDEIFPGGDLPQAKGVIEHAQRAGFGVQRVQALRPHYAR
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHH
TLDTWAAALRARRDEAIAIQSEEVYDRYMKYLTGCADLFREGYTDVAQFTLTKG
HHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7604045 [H]