Click here to switch to the map view.

The map label for this gene is ywlC [H]

Identifier: 52843166

GI number: 52843166

Start: 3361982

End: 3362950

Strand: Direct

Name: ywlC [H]

Synonym: lpg2972

Alternate gene names: 52843166

Gene position: 3361982-3362950 (Clockwise)

Preceding gene: 52843165

Following gene: 52843172

Centisome position: 98.95

GC content: 40.35

Gene sequence:

>969_bases
ATGTCCATAATTACTACCAATCTCAATCGGGCAATTCATGATTTACAGCAAGGAAAACCAGTAGCTATACCGACTGAAAC
GGTTTACGGATTGGCAGCACCAATAAACAATAATGCTGCCATCAGAGCTGTGTTTGAAATGAAAGGCAGACCTTTAAATC
ATCCTTTGATTGTTCATATTGCTTCCAATTGGGATCTGCATAAGCTCGTGGAAGAGGTACCTGAGTATGCGCATCAATTA
GCTAGCAAGTTCTGGCCTGGACCATTGACCCTGGTATTCTATTGTAAAAAAGATCAAATCAATCCGCTCATTACCGGTGG
TCAATCTACCATAGCGATAAGATGCCCGGATCATCCCTTGACACAAAAATTGTTACAAAAATTAAATATTCCTGTGGTGG
CACCCTCTGCCAATCCTTTTGGAAAAATTAGCCCGACAACCGCTTTGCACGTTAAACAATCATTTAATGATGCCGAGTTA
ACTATCCTGGACGGAGGACGCTGTCGTGTGGGTATTGAATCAACCATTGTAGATGCTACCAATCCTGTTTCTTATCAAAT
TTTACGCCATGGAATAATAGACGAAAAAACTATTGCTGAAACGATTGCCATAGGTTGCTCGACTCAAAAAAATAATATTC
GTGTCCCTGGTAAATTGGATAGCCATTATCAACCACAAAAAACTTTATATTATTTTGATCAATATGAAACCCTTTCCGAA
TTTTGTCAAAAACGCAAAGGGACTGTTTATGTCATAGCGAATAGACAACCCCCTGGTGTCGAGACTAATCTCTTTCATCC
ACTGGGAATGCATCCTGAAAAATCGGCCTATGATTTGTATTATCAACTAAGATTAGCTGATACATCCGATGCCATTTGTA
TCGCTATCGAGCTACCACCCAATACGAGTGAATGGCAGGGAGTACGAGAAAGAATATTAAAAGCCGGGTTCCCCTATTCG
CAGCAATAA

Upstream 100 bases:

>100_bases
CCTCCAGTTTATTTATAGAAGCTTATTCTTATTATTAAATTGAGCTTAAAAACAGATAGAAAGACCCTGAAACATAACTA
TTTTTTATCGAGCCCCTTAT

Downstream 100 bases:

>100_bases
ATCTCAAGTAATTTATACTTTTTTGATTTCGCGCAATTCTGTATTGACAGAACACTATAATTTGCGTAACTTAACGCCCT
ATGCCGAGGTGGTGGAATTG

Product: Sua5/YciO/YrdC/YwlC family protein

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSIITTNLNRAIHDLQQGKPVAIPTETVYGLAAPINNNAAIRAVFEMKGRPLNHPLIVHIASNWDLHKLVEEVPEYAHQL
ASKFWPGPLTLVFYCKKDQINPLITGGQSTIAIRCPDHPLTQKLLQKLNIPVVAPSANPFGKISPTTALHVKQSFNDAEL
TILDGGRCRVGIESTIVDATNPVSYQILRHGIIDEKTIAETIAIGCSTQKNNIRVPGKLDSHYQPQKTLYYFDQYETLSE
FCQKRKGTVYVIANRQPPGVETNLFHPLGMHPEKSAYDLYYQLRLADTSDAICIAIELPPNTSEWQGVRERILKAGFPYS
QQ

Sequences:

>Translated_322_residues
MSIITTNLNRAIHDLQQGKPVAIPTETVYGLAAPINNNAAIRAVFEMKGRPLNHPLIVHIASNWDLHKLVEEVPEYAHQL
ASKFWPGPLTLVFYCKKDQINPLITGGQSTIAIRCPDHPLTQKLLQKLNIPVVAPSANPFGKISPTTALHVKQSFNDAEL
TILDGGRCRVGIESTIVDATNPVSYQILRHGIIDEKTIAETIAIGCSTQKNNIRVPGKLDSHYQPQKTLYYFDQYETLSE
FCQKRKGTVYVIANRQPPGVETNLFHPLGMHPEKSAYDLYYQLRLADTSDAICIAIELPPNTSEWQGVRERILKAGFPYS
QQ
>Mature_321_residues
SIITTNLNRAIHDLQQGKPVAIPTETVYGLAAPINNNAAIRAVFEMKGRPLNHPLIVHIASNWDLHKLVEEVPEYAHQLA
SKFWPGPLTLVFYCKKDQINPLITGGQSTIAIRCPDHPLTQKLLQKLNIPVVAPSANPFGKISPTTALHVKQSFNDAELT
ILDGGRCRVGIESTIVDATNPVSYQILRHGIIDEKTIAETIAIGCSTQKNNIRVPGKLDSHYQPQKTLYYFDQYETLSEF
CQKRKGTVYVIANRQPPGVETNLFHPLGMHPEKSAYDLYYQLRLADTSDAICIAIELPPNTSEWQGVRERILKAGFPYSQ
Q

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=207, Percent_Identity=34.7826086956522, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI2367210, Length=163, Percent_Identity=31.9018404907975, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=202, Percent_Identity=29.7029702970297, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321269, Length=370, Percent_Identity=28.6486486486486, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI78707274, Length=189, Percent_Identity=30.1587301587302, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 35944; Mature: 35812

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIITTNLNRAIHDLQQGKPVAIPTETVYGLAAPINNNAAIRAVFEMKGRPLNHPLIVHI
CEEEECCHHHHHHHHHCCCCEEECCHHHEEEECCCCCCCEEEEEEECCCCCCCCCEEEEE
ASNWDLHKLVEEVPEYAHQLASKFWPGPLTLVFYCKKDQINPLITGGQSTIAIRCPDHPL
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCHH
TQKLLQKLNIPVVAPSANPFGKISPTTALHVKQSFNDAELTILDGGRCRVGIESTIVDAT
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCEEEEECCCEEECCC
NPVSYQILRHGIIDEKTIAETIAIGCSTQKNNIRVPGKLDSHYQPQKTLYYFDQYETLSE
CCHHHHHHHCCCCCCHHHHHHHEECCCCCCCCEECCCCCCCCCCCCCEEEEEHHHHHHHH
FCQKRKGTVYVIANRQPPGVETNLFHPLGMHPEKSAYDLYYQLRLADTSDAICIAIELPP
HHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECC
NTSEWQGVRERILKAGFPYSQQ
CCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIITTNLNRAIHDLQQGKPVAIPTETVYGLAAPINNNAAIRAVFEMKGRPLNHPLIVHI
EEEECCHHHHHHHHHCCCCEEECCHHHEEEECCCCCCCEEEEEEECCCCCCCCCEEEEE
ASNWDLHKLVEEVPEYAHQLASKFWPGPLTLVFYCKKDQINPLITGGQSTIAIRCPDHPL
ECCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCHH
TQKLLQKLNIPVVAPSANPFGKISPTTALHVKQSFNDAELTILDGGRCRVGIESTIVDAT
HHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEEEECCEEEEECCCEEECCC
NPVSYQILRHGIIDEKTIAETIAIGCSTQKNNIRVPGKLDSHYQPQKTLYYFDQYETLSE
CCHHHHHHHCCCCCCHHHHHHHEECCCCCCCCEECCCCCCCCCCCCCEEEEEHHHHHHHH
FCQKRKGTVYVIANRQPPGVETNLFHPLGMHPEKSAYDLYYQLRLADTSDAICIAIELPP
HHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCEEEEEEEECC
NTSEWQGVRERILKAGFPYSQQ
CCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]