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The map label for this gene is lpxB

Identifier: 52843139

GI number: 52843139

Start: 3330887

End: 3332044

Strand: Reverse

Name: lpxB

Synonym: lpg2945

Alternate gene names: 52843139

Gene position: 3332044-3330887 (Counterclockwise)

Preceding gene: 52843140

Following gene: 52843135

Centisome position: 98.07

GC content: 39.98

Gene sequence:

>1158_bases
TTGACTATGAAAAGACCGACCCGAATTGCGATGGTTGCCGGCGAACTATCTGGAGATTTACTGGGAGCAGGGGTAATTCG
TGAGCTGAAACAGCATTTAACCAACGTAGAATTCATGGGGGTCGGTGGTCCTCAAATGCTCAAGGAAGGCTTCCATTCCC
TGATTGATATCTCCGAGCTTTCTGTGATGGGAATCAGTGATGTTCTGCGACGATATCCTCAACTGTATTTAATAAGAGAA
AGGTTATTGAGGGAATGGACAATTAATCCACCAGATGTATTCATTGGGATTGATTACCCTGACTTTAATTTATCCGTTGA
AGCACGGTTAAAAAAACAGCATATTAAAACCATTCATCTGGTGAGCCCCAAAGTTTGGGCATGGCGACAAAAACGGGTGC
ATTTAATAAAAAAGGCAGTTGATTTAGTATTAACCCTATTTCCATTTGAAGAAGCATTTTATCGACAACATGGGGTATCG
GCACAATTTATTGGTCATCCTTTAGCTGATTTAATCGAAATAAACCCAAGTTGTTCTACTTTGCGTAAAAAATATAACTA
CCATTCTGATGACACCATTCTGGCAGTATTACCGGGTAGTCGGGTAGGTGAAATCAAATACATGGGGCCCTTGTTTTTGG
AAGTAATGCAAAGAATTGCTGTGGAGAGGCCTCATGTGCATTTCATAGTACCGATTGCGTGTCAGGATTTGTATCCAGTT
TTTTTTAAACAACTCCATGCCGAGTATGGCCACTTAAAAATTCAGATTATTCAAGGGAATGCTCGTGAGGCCATGGCTAT
CTCTGACGTTGTTTTAACAAAATCCGGAACAGCAACACTTGAGGCGATGCTTTTAAAACGACCCATGGTGGTTGCCTTTA
AATGGGGTATACTTACTCATGCGATTATCGCGCCGCAAGTAAAAGTTCCCTATATTGCGTTGCCTAATTTATTGGCTGGT
AAAAAATTAATCCCTGAATTTGTTCAGGAAAAAGCGAATGTTGATAGCATTACAGAATCAGTTCTGAATTTACTCGACTC
ATCCAATCAAAACGAACTAATTAAACAATTTACTGATATTCACTGCACATTAAGGCAAAATGCTAATGAGAAAGCGGCTT
TATCTATCCTCAGGATTTTGGGGACTTCTTTGACTTAA

Upstream 100 bases:

>100_bases
ACTCAATTGGCAATCTGTGCGTTTGCGGAATTAATACTGCTTGGCTATGGTTATTAGTTTAGGCTAACATCAAGTCATTT
AAATTTTATATTGGTGCAAT

Downstream 100 bases:

>100_bases
TCGCTGTTTTTAAAAATCGGATTTGTTTTTGCCAATCACTAATTGATACCGCTGGGTGGCCGCCGACCCTGTCTCCGGAT
TTCACATTTTTATAGACTTT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MTMKRPTRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISELSVMGISDVLRRYPQLYLIRE
RLLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHLVSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYRQHGVS
AQFIGHPLADLIEINPSCSTLRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAVERPHVHFIVPIACQDLYPV
FFKQLHAEYGHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTHAIIAPQVKVPYIALPNLLAG
KKLIPEFVQEKANVDSITESVLNLLDSSNQNELIKQFTDIHCTLRQNANEKAALSILRILGTSLT

Sequences:

>Translated_385_residues
MTMKRPTRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISELSVMGISDVLRRYPQLYLIRE
RLLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHLVSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYRQHGVS
AQFIGHPLADLIEINPSCSTLRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAVERPHVHFIVPIACQDLYPV
FFKQLHAEYGHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTHAIIAPQVKVPYIALPNLLAG
KKLIPEFVQEKANVDSITESVLNLLDSSNQNELIKQFTDIHCTLRQNANEKAALSILRILGTSLT
>Mature_384_residues
TMKRPTRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISELSVMGISDVLRRYPQLYLIRER
LLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHLVSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYRQHGVSA
QFIGHPLADLIEINPSCSTLRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAVERPHVHFIVPIACQDLYPVF
FKQLHAEYGHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTHAIIAPQVKVPYIALPNLLAGK
KLIPEFVQEKANVDSITESVLNLLDSSNQNELIKQFTDIHCTLRQNANEKAALSILRILGTSLT

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=381, Percent_Identity=42.7821522309711, Blast_Score=302, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 43477; Mature: 43346

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKRPTRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISEL
CCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
SVMGISDVLRRYPQLYLIRERLLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEE
VSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYRQHGVSAQFIGHPLADLIEINPSCST
ECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHCCCHHHHHCCCCCHHH
LRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAVERPHVHFIVPIACQDLYPV
HHHHCCCCCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
FFKQLHAEYGHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTH
HHHHHHHCCCCEEEEEEECCCCCHHHHHHEEEECCCHHHHHHHHHCCCCCEEEEHHHHHH
AIIAPQVKVPYIALPNLLAGKKLIPEFVQEKANVDSITESVLNLLDSSNQNELIKQFTDI
HHHCCCCCCCEEECCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
HCTLRQNANEKAALSILRILGTSLT
EEEECCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TMKRPTRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISEL
CCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHH
SVMGISDVLRRYPQLYLIRERLLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHL
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEE
VSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYRQHGVSAQFIGHPLADLIEINPSCST
ECCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHCCCHHHHHCCCCCHHH
LRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAVERPHVHFIVPIACQDLYPV
HHHHCCCCCCCEEEEEECCCCCCCEEECCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHH
FFKQLHAEYGHLKIQIIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTH
HHHHHHHCCCCEEEEEEECCCCCHHHHHHEEEECCCHHHHHHHHHCCCCCEEEEHHHHHH
AIIAPQVKVPYIALPNLLAGKKLIPEFVQEKANVDSITESVLNLLDSSNQNELIKQFTDI
HHHCCCCCCCEEECCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
HCTLRQNANEKAALSILRILGTSLT
EEEECCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA