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The map label for this gene is fumC

Identifier: 52843131

GI number: 52843131

Start: 3322598

End: 3323992

Strand: Direct

Name: fumC

Synonym: lpg2937

Alternate gene names: 52843131

Gene position: 3322598-3323992 (Clockwise)

Preceding gene: 52843125

Following gene: 52843136

Centisome position: 97.79

GC content: 46.95

Gene sequence:

>1395_bases
ATGGCTAAAACACGTGTAGAAACAGACAGCATGGGTGAAATTGAAGTCCCGTCTGATAAATATTGGGGCGCCCAAACCGA
ACGTTCATTGCATCACTTCAATATAGGCAAAGACATTATGCCACGCGAAGTAACCCATGCCTTTGGTATCCTGAAAAAGG
CAGCCGCCCTGACGAATCTTGAATTAGGCAAACTGCCAAAAGACAAAGCGGATTTGATTGTTCAGGCAGCAGAAGAAGTG
AGCAAAGGACTATTGGATGAGCATTTTCCCTTGCATGTCTGGCAAACGGGAAGCGGCACACAATCGAATATGAACGCCAA
TGAAGTCATTTCCAATCGGGCCATTGAGCTGGCTGGCGGCACCCTGGGAAGCAAGTCCCCTATTCATCCCAATGATCACG
TCAATATGTCTCAATCATCGAATGACACCTTCCCAACAGCCATGCATATTGCAGCGGCGATAGCTTTTAACGAAAAATTG
TTACCTGCTGTACGCAATTTACGTCATGTTTTCGCAGCGAAAATGGACGCTTTCAAAAACATCATAAAAATTGGCAGAAC
CCATTTGCAAGATGCGGTTCCACTGACTTTGGGGCAAGAGTTTTCAGGTTATGTTGCCCAACTGGATGCGTGCGTTCACC
GTCTGGAAGAAGTCTTGCCTGAATTATATGAGCTGGCTGCCGGGGGCACTGCCGTTGGAACCGGATTGAACACCCATCCG
CAATTCGCAGTCAAAGTTGCTGAACACATCGCTAAAATAACCAAACTGCCTTTTGTGACCGCTCCTAACAAATTTGCCGC
TCTGGCTTCTCACGAACCTCTGGTGCATGCGCACGGTGCCATGAAAACTCTCGCCTGCGCATTAATGAAAATCGCCAATG
ACATACGCTGGCTCGCCTCAGGACCTCGTTGCGGGATTGGTGAGCTGATTATTCCAGAAAATGAGCCAGGCTCATCCATC
ATGCCAGGCAAAGTCAACCCGACACAATGCGAAGCCATGACCATGGTTTGTGCCCAGGTACTGGGTAATGATACAGCCGT
TGGAATTGCTGACAGCCAGGGTAATTTTGAATTAAACGTGTTTAAACCGGTTATCATATTTAACGTATTGCACTCATTAA
ACCTGCTCGCCGACAGCTGCCATTCCTTCCAGGAGTTTTGCGCAGAAGGAATAGAGCCTAATCAGCCGGTGATTGATTAC
TATTTACACCATTCCCTCATGCTGGTTACTGCCCTTAATCAACACATTGGTTATGATAAAGCGGCTAAAATCGCCAAAAC
CGCTCATCATGACAATATTTCATTGCAAGAAGCCGCCGTGAAACTGGGAATTTTAACCGCCGAGCAATTTGCTGAGTTTG
TGAAACCGGAAAAGATGATTTCCCCTGAGCAATGA

Upstream 100 bases:

>100_bases
AATTTTGGCGATTGATTTTATTCTTTCCCAACTCGCTGATAAAGCAGCTAGACATAAATAAACATAATCAACAGATTAAC
TTTGCTAAGGAATTGATAAC

Downstream 100 bases:

>100_bases
AATTGAGAGGGTTAAGACATACCGGGGTTCTGGTATGTCTTAACCTAAGATGTAGTAGAAAACAAAATGACAACAAACAA
TAGTTTGAATTTTACTCAAC

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MAKTRVETDSMGEIEVPSDKYWGAQTERSLHHFNIGKDIMPREVTHAFGILKKAAALTNLELGKLPKDKADLIVQAAEEV
SKGLLDEHFPLHVWQTGSGTQSNMNANEVISNRAIELAGGTLGSKSPIHPNDHVNMSQSSNDTFPTAMHIAAAIAFNEKL
LPAVRNLRHVFAAKMDAFKNIIKIGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHP
QFAVKVAEHIAKITKLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLASGPRCGIGELIIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNVFKPVIIFNVLHSLNLLADSCHSFQEFCAEGIEPNQPVIDY
YLHHSLMLVTALNQHIGYDKAAKIAKTAHHDNISLQEAAVKLGILTAEQFAEFVKPEKMISPEQ

Sequences:

>Translated_464_residues
MAKTRVETDSMGEIEVPSDKYWGAQTERSLHHFNIGKDIMPREVTHAFGILKKAAALTNLELGKLPKDKADLIVQAAEEV
SKGLLDEHFPLHVWQTGSGTQSNMNANEVISNRAIELAGGTLGSKSPIHPNDHVNMSQSSNDTFPTAMHIAAAIAFNEKL
LPAVRNLRHVFAAKMDAFKNIIKIGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHP
QFAVKVAEHIAKITKLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLASGPRCGIGELIIPENEPGSSI
MPGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNVFKPVIIFNVLHSLNLLADSCHSFQEFCAEGIEPNQPVIDY
YLHHSLMLVTALNQHIGYDKAAKIAKTAHHDNISLQEAAVKLGILTAEQFAEFVKPEKMISPEQ
>Mature_463_residues
AKTRVETDSMGEIEVPSDKYWGAQTERSLHHFNIGKDIMPREVTHAFGILKKAAALTNLELGKLPKDKADLIVQAAEEVS
KGLLDEHFPLHVWQTGSGTQSNMNANEVISNRAIELAGGTLGSKSPIHPNDHVNMSQSSNDTFPTAMHIAAAIAFNEKLL
PAVRNLRHVFAAKMDAFKNIIKIGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHPQ
FAVKVAEHIAKITKLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLASGPRCGIGELIIPENEPGSSIM
PGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNVFKPVIIFNVLHSLNLLADSCHSFQEFCAEGIEPNQPVIDYY
LHHSLMLVTALNQHIGYDKAAKIAKTAHHDNISLQEAAVKLGILTAEQFAEFVKPEKMISPEQ

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=461, Percent_Identity=65.0759219088937, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=49.3506493506493, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1787896, Length=460, Percent_Identity=60.6521739130435, Blast_Score=573, Evalue=1e-164,
Organism=Escherichia coli, GI87082375, Length=461, Percent_Identity=38.8286334056399, Blast_Score=324, Evalue=8e-90,
Organism=Caenorhabditis elegans, GI17553882, Length=465, Percent_Identity=66.8817204301075, Blast_Score=629, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI32565146, Length=328, Percent_Identity=65.8536585365854, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324993, Length=461, Percent_Identity=60.7375271149675, Blast_Score=572, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=61.6883116883117, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=61.6883116883117, Blast_Score=581, Evalue=1e-166,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=60.475161987041, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24662684, Length=463, Percent_Identity=59.8272138228942, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24583245, Length=464, Percent_Identity=52.801724137931, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003031
- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50360; Mature: 50229

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTRVETDSMGEIEVPSDKYWGAQTERSLHHFNIGKDIMPREVTHAFGILKKAAALTNL
CCCCCCCCCCCCCEECCCCCCCCCHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
ELGKLPKDKADLIVQAAEEVSKGLLDEHFPLHVWQTGSGTQSNMNANEVISNRAIELAGG
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEECC
TLGSKSPIHPNDHVNMSQSSNDTFPTAMHIAAAIAFNEKLLPAVRNLRHVFAAKMDAFKN
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHP
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCH
QFAVKVAEHIAKITKLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLAS
HHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGELIIPENEPGSSIMPGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
FKPVIIFNVLHSLNLLADSCHSFQEFCAEGIEPNQPVIDYYLHHSLMLVTALNQHIGYDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
AAKIAKTAHHDNISLQEAAVKLGILTAEQFAEFVKPEKMISPEQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC
>Mature Secondary Structure 
AKTRVETDSMGEIEVPSDKYWGAQTERSLHHFNIGKDIMPREVTHAFGILKKAAALTNL
CCCCCCCCCCCCEECCCCCCCCCHHHCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCC
ELGKLPKDKADLIVQAAEEVSKGLLDEHFPLHVWQTGSGTQSNMNANEVISNRAIELAGG
HHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEECC
TLGSKSPIHPNDHVNMSQSSNDTFPTAMHIAAAIAFNEKLLPAVRNLRHVFAAKMDAFKN
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IIKIGRTHLQDAVPLTLGQEFSGYVAQLDACVHRLEEVLPELYELAAGGTAVGTGLNTHP
HHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCH
QFAVKVAEHIAKITKLPFVTAPNKFAALASHEPLVHAHGAMKTLACALMKIANDIRWLAS
HHHHHHHHHHHHHHHCCEEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPRCGIGELIIPENEPGSSIMPGKVNPTQCEAMTMVCAQVLGNDTAVGIADSQGNFELNV
CCCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEE
FKPVIIFNVLHSLNLLADSCHSFQEFCAEGIEPNQPVIDYYLHHSLMLVTALNQHIGYDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
AAKIAKTAHHDNISLQEAAVKLGILTAEQFAEFVKPEKMISPEQ
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA