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The map label for this gene is ampH [C]

Identifier: 52843113

GI number: 52843113

Start: 3305184

End: 3306362

Strand: Direct

Name: ampH [C]

Synonym: lpg2919

Alternate gene names: 52843113

Gene position: 3305184-3306362 (Clockwise)

Preceding gene: 52843106

Following gene: 52843114

Centisome position: 97.28

GC content: 34.61

Gene sequence:

>1179_bases
ATGCATATCAAAAATATATTCACATGGAATTTAATGGGCGCAGTAATTCTATCTATGCCCTTATTTGCGGGCGAGCAAGT
TAAATTGAAATCAATTGACTCATTAATTGATAAATACATTGAGAAATATAAAAATGAAGAGCTGGTTACAGGTGTGGGTG
CGACTTTTTTAAGCGGAACTGAAATAATATCAACAGCCCATGGTTTTGAGAACAATAAAAGAAAAAAACGCCTTACAAAT
AATGCATATTTTCAAATTGGCAGTATAACCAAATCGTTTACAGCCGCATTAATCTTAAAGCTTGAAGCGGAAGGGAAATT
AAACATCAACCAAACAATTGGAGATTGGTTGCCAGAATATGATGACTGGAAAGGCATTACTATAAAGCAATTACTTAATA
TGACAAGTACAATTCCAGGTTATGCAACGATTCCAACGCTTGCAGATTCGATTACTGATAATCCTAAAAAACAGTGGACT
AGTAAAGAACTGGTAGATTTAGCATATGGATATAAACACCCCACCTCAGGTTATAATTACTCTGATACCAACTACTTAAT
TCTGGGTATGATTATAGAAAAAGTCACTCACGATTCCTTTCATAATCAATTACAGAAAAAAATTCTAAAGCCCTTACAAT
TAAAAGAGACCTATTATATTACTGATTCTTATACCCCATATTTTTTAAAAAAAATGCCGGAAAGTTACTATTATGGTAGA
ACAGTGGAAAACTTAAAACATGGTCAAAAGTCAACCAATGACAATTTATCAATGGCGGGACCTGCTGGTGCTATTGTCGC
AACTACATCGGATGTCGCCAAATGGATAAAAGCTTTATTTTCATCCGATTTTTTACTGCCGAAACAGCAAATGGAGTTAA
AATCCCTCATTTCGATGAAAACGGGTACTCCAATCTCCCATGTTGATTCAGAAGAGCCTAATGGCTTTGGTTTAGGTGTT
GTTCAAGGCTATAAGCCGCAATTGGGAAAATATTGGTATTATGAAGGTGATACAGTGGGATTTAGAGTCTTATATATTTA
TCATCCTTGTAATGAAAAAATAGTGGTTATTGCATTAAACAGTTCGCCTTTTGTTGATGAAGCAGCGGGAGATCATAGTG
GTGATTTGTTATTGGAATTGTACAAAAACGCTTTTGGCATATCACAGAAATGTGAATAA

Upstream 100 bases:

>100_bases
CCATAACCCAGGTATTGATATGCTTGTATGTAAGTAAACTGGAATAAAAAGAAATTAGTGTTCATAGTATAACTGAGGCT
TTGATCCACAGGAGTTAAAT

Downstream 100 bases:

>100_bases
AATAGGGTAAAATCCAACTTCTTTTGGCAACCTTTCAAAAAGAGGCGAGTCATGCAAGAGAGATATAGGTTATGGCCTTA
AAGTACTTGTAAATCCGGTG

Product: (serine-type) D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MHIKNIFTWNLMGAVILSMPLFAGEQVKLKSIDSLIDKYIEKYKNEELVTGVGATFLSGTEIISTAHGFENNKRKKRLTN
NAYFQIGSITKSFTAALILKLEAEGKLNINQTIGDWLPEYDDWKGITIKQLLNMTSTIPGYATIPTLADSITDNPKKQWT
SKELVDLAYGYKHPTSGYNYSDTNYLILGMIIEKVTHDSFHNQLQKKILKPLQLKETYYITDSYTPYFLKKMPESYYYGR
TVENLKHGQKSTNDNLSMAGPAGAIVATTSDVAKWIKALFSSDFLLPKQQMELKSLISMKTGTPISHVDSEEPNGFGLGV
VQGYKPQLGKYWYYEGDTVGFRVLYIYHPCNEKIVVIALNSSPFVDEAAGDHSGDLLLELYKNAFGISQKCE

Sequences:

>Translated_392_residues
MHIKNIFTWNLMGAVILSMPLFAGEQVKLKSIDSLIDKYIEKYKNEELVTGVGATFLSGTEIISTAHGFENNKRKKRLTN
NAYFQIGSITKSFTAALILKLEAEGKLNINQTIGDWLPEYDDWKGITIKQLLNMTSTIPGYATIPTLADSITDNPKKQWT
SKELVDLAYGYKHPTSGYNYSDTNYLILGMIIEKVTHDSFHNQLQKKILKPLQLKETYYITDSYTPYFLKKMPESYYYGR
TVENLKHGQKSTNDNLSMAGPAGAIVATTSDVAKWIKALFSSDFLLPKQQMELKSLISMKTGTPISHVDSEEPNGFGLGV
VQGYKPQLGKYWYYEGDTVGFRVLYIYHPCNEKIVVIALNSSPFVDEAAGDHSGDLLLELYKNAFGISQKCE
>Mature_392_residues
MHIKNIFTWNLMGAVILSMPLFAGEQVKLKSIDSLIDKYIEKYKNEELVTGVGATFLSGTEIISTAHGFENNKRKKRLTN
NAYFQIGSITKSFTAALILKLEAEGKLNINQTIGDWLPEYDDWKGITIKQLLNMTSTIPGYATIPTLADSITDNPKKQWT
SKELVDLAYGYKHPTSGYNYSDTNYLILGMIIEKVTHDSFHNQLQKKILKPLQLKETYYITDSYTPYFLKKMPESYYYGR
TVENLKHGQKSTNDNLSMAGPAGAIVATTSDVAKWIKALFSSDFLLPKQQMELKSLISMKTGTPISHVDSEEPNGFGLGV
VQGYKPQLGKYWYYEGDTVGFRVLYIYHPCNEKIVVIALNSSPFVDEAAGDHSGDLLLELYKNAFGISQKCE

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 44109; Mature: 44109

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIKNIFTWNLMGAVILSMPLFAGEQVKLKSIDSLIDKYIEKYKNEELVTGVGATFLSGT
CCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHCCH
EIISTAHGFENNKRKKRLTNNAYFQIGSITKSFTAALILKLEAEGKLNINQTIGDWLPEY
HHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHEEEEEEEECCCCEEECCCHHHHCCCC
DDWKGITIKQLLNMTSTIPGYATIPTLADSITDNPKKQWTSKELVDLAYGYKHPTSGYNY
CCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SDTNYLILGMIIEKVTHDSFHNQLQKKILKPLQLKETYYITDSYTPYFLKKMPESYYYGR
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCHHHHHHCCCHHHCCC
TVENLKHGQKSTNDNLSMAGPAGAIVATTSDVAKWIKALFSSDFLLPKQQMELKSLISMK
HHHHHHCCCCCCCCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
TGTPISHVDSEEPNGFGLGVVQGYKPQLGKYWYYEGDTVGFRVLYIYHPCNEKIVVIALN
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEEEEEC
SSPFVDEAAGDHSGDLLLELYKNAFGISQKCE
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHIKNIFTWNLMGAVILSMPLFAGEQVKLKSIDSLIDKYIEKYKNEELVTGVGATFLSGT
CCCCCEEHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHHCCH
EIISTAHGFENNKRKKRLTNNAYFQIGSITKSFTAALILKLEAEGKLNINQTIGDWLPEY
HHHHHHCCCCCCHHHHHHCCCCEEEECCHHHHHHEEEEEEEECCCCEEECCCHHHHCCCC
DDWKGITIKQLLNMTSTIPGYATIPTLADSITDNPKKQWTSKELVDLAYGYKHPTSGYNY
CCCCCCHHHHHHHHHHCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
SDTNYLILGMIIEKVTHDSFHNQLQKKILKPLQLKETYYITDSYTPYFLKKMPESYYYGR
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEECCEEEEECCCCHHHHHHCCCHHHCCC
TVENLKHGQKSTNDNLSMAGPAGAIVATTSDVAKWIKALFSSDFLLPKQQMELKSLISMK
HHHHHHCCCCCCCCCCEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
TGTPISHVDSEEPNGFGLGVVQGYKPQLGKYWYYEGDTVGFRVLYIYHPCNEKIVVIALN
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEEEEECCCCEEEEEEEC
SSPFVDEAAGDHSGDLLLELYKNAFGISQKCE
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]