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The map label for this gene is ubiB [H]

Identifier: 52843099

GI number: 52843099

Start: 3286884

End: 3288533

Strand: Direct

Name: ubiB [H]

Synonym: lpg2905

Alternate gene names: 52843099

Gene position: 3286884-3288533 (Clockwise)

Preceding gene: 52843098

Following gene: 52843100

Centisome position: 96.74

GC content: 41.88

Gene sequence:

>1650_bases
ATGAAATCAATTAAGCAACTTATTCGTCTTATACATATCAATTATATTTTAGCCAAAAATGGTCTAGATAATGTTGTTGT
GTCTATCAAACTGTTTGCTCCTTTACGTTTTATAGTGTATTTAAACCCATGGAACTGGCTTCGCAAGGAGAAATTAACGC
GCGGTGAAGCGCTGCGCAAATCGCTGGAGGAACTCGGCCCCATCTTCATTAAATTCGGACAAGCCCTTTCCACACGCCCC
GATATACTTCCTGAAGACATCGCAAAAGAATTAAGTAAACTGCAAGACAAAGTTCCTCCATTCCCCAGCCATATCGCCAT
GAACATCATTGAACAGGCCTATAAACAGTCTGCCTATGATGTTTTTGCCCAATTTGATCCGATCGCCCTGGCTTCCGCTT
CCATGGCACAAGTACATGCGGCAACCCTGAAGACAGGGGAAAATGTCGTTGTAAAAATACTAAGGCCCAATATGCGCCGG
CTTATAGAACAAGATTTAAGTATCATGTACACCATCGCCGCATTGGCTGACCGCTATTGGCCTGAGGGAAAGCGCTTCAA
ACCCAAAGAGATAGTCAAGGAATTTGAACATACCTTACTGGATGAACTGGATTTAATGAGAGAAGCGGCAAATGCCGCTC
AATTGCGAAGAAATTTCAATCAATCTCCGATGTTATATATACCTGAAATCTATTGGGATTATTGCCATCATAATATCCTG
GTCATTGAACGCATTCATGGCATACCCGTGACCGATATAGCCAGTCTTAGAGATCACGGCATTGACATTAAAAAACTGGC
CGAGCGTGGGGTAGAAATTTTCTTTACTCAAGTCTTCCGGGATTGTTTTTTTCATGCAGACATGCACCCGGGAAATATCT
TTGTCTCCTACCAAAACCCCAAAGACCCTCAGTATATTTGTGTTGATTTTGGCATCATTGGGACTCTGACAGATAATGAC
AAGCGTTATCTGGCTGAAAACCTGGTCGCTTTTTTTAACCGTGACTACAAGCGCGTAGCGGAATTACATGTGGAGTCAGG
ATGGGTATCGCGTGACACCCCTGTTGCAGAATTTGAAAGCAGCATAAGAACCGTTTGCGAACCTATTTTTGAAAAGCCAT
TAAAAGATATTTCCTTTGGACAAGTGGTTTTCCGTTTATTCCAGGTTGCCAGAAGGTTTCATATGGAAGTGCAGCCCCAA
CTGATTTTGCTGCAAAAAACCCTGTTGGCGATAGAAGGTTTGGGCAGACAACTCTATCCTGAATTGGATTTATGGGCTAC
AGCAAAACCATTCCTTGAAAAATGGGTGCGGGAACAAATGGGGCCTAAAGCATTCATTAAACGCTTAAAGCAAAATCTGC
CCTTTTTTACCGAGCAACTCCCCCATATGCCCAAACTGATTTTTGATATATTGGAGATGAAAAAGGATCAGTTGTTAACA
GTCCATGAACTCACACGCTTGCAATCTGAAAATAACAATCAGACCATCCAATGGAAGAGTATGGGACTGGGTGTATTTTT
CTCATTTTTATCATTAGGCGTCATTAGCTATTTTGATTTGCTGGATTATAATCATCTCACAACCATCACGATAGCTGGTT
CTGTTTTAGCTGGAATTTTTGTACTCATCAACCGCAAGATAAGGAACTAA

Upstream 100 bases:

>100_bases
AAGGCAATTAAACGATTGGATAATTTTATTCAGGATCTGGATGGATTATCATTGCATATTGAGCGGCTGGAAGCTCGAAA
TCAACAACCGATGAGCTGTT

Downstream 100 bases:

>100_bases
CATGGGATTAAGTGGAATAAGTCCGTTATCACTTTTATTAATTCTAGCCATTATTATAGCCTTGTTTGGCACTTCCAAAT
TAAAAACAATAGGCTCTGAC

Product: ubiquinone biosynthesis AarF

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MKSIKQLIRLIHINYILAKNGLDNVVVSIKLFAPLRFIVYLNPWNWLRKEKLTRGEALRKSLEELGPIFIKFGQALSTRP
DILPEDIAKELSKLQDKVPPFPSHIAMNIIEQAYKQSAYDVFAQFDPIALASASMAQVHAATLKTGENVVVKILRPNMRR
LIEQDLSIMYTIAALADRYWPEGKRFKPKEIVKEFEHTLLDELDLMREAANAAQLRRNFNQSPMLYIPEIYWDYCHHNIL
VIERIHGIPVTDIASLRDHGIDIKKLAERGVEIFFTQVFRDCFFHADMHPGNIFVSYQNPKDPQYICVDFGIIGTLTDND
KRYLAENLVAFFNRDYKRVAELHVESGWVSRDTPVAEFESSIRTVCEPIFEKPLKDISFGQVVFRLFQVARRFHMEVQPQ
LILLQKTLLAIEGLGRQLYPELDLWATAKPFLEKWVREQMGPKAFIKRLKQNLPFFTEQLPHMPKLIFDILEMKKDQLLT
VHELTRLQSENNNQTIQWKSMGLGVFFSFLSLGVISYFDLLDYNHLTTITIAGSVLAGIFVLINRKIRN

Sequences:

>Translated_549_residues
MKSIKQLIRLIHINYILAKNGLDNVVVSIKLFAPLRFIVYLNPWNWLRKEKLTRGEALRKSLEELGPIFIKFGQALSTRP
DILPEDIAKELSKLQDKVPPFPSHIAMNIIEQAYKQSAYDVFAQFDPIALASASMAQVHAATLKTGENVVVKILRPNMRR
LIEQDLSIMYTIAALADRYWPEGKRFKPKEIVKEFEHTLLDELDLMREAANAAQLRRNFNQSPMLYIPEIYWDYCHHNIL
VIERIHGIPVTDIASLRDHGIDIKKLAERGVEIFFTQVFRDCFFHADMHPGNIFVSYQNPKDPQYICVDFGIIGTLTDND
KRYLAENLVAFFNRDYKRVAELHVESGWVSRDTPVAEFESSIRTVCEPIFEKPLKDISFGQVVFRLFQVARRFHMEVQPQ
LILLQKTLLAIEGLGRQLYPELDLWATAKPFLEKWVREQMGPKAFIKRLKQNLPFFTEQLPHMPKLIFDILEMKKDQLLT
VHELTRLQSENNNQTIQWKSMGLGVFFSFLSLGVISYFDLLDYNHLTTITIAGSVLAGIFVLINRKIRN
>Mature_549_residues
MKSIKQLIRLIHINYILAKNGLDNVVVSIKLFAPLRFIVYLNPWNWLRKEKLTRGEALRKSLEELGPIFIKFGQALSTRP
DILPEDIAKELSKLQDKVPPFPSHIAMNIIEQAYKQSAYDVFAQFDPIALASASMAQVHAATLKTGENVVVKILRPNMRR
LIEQDLSIMYTIAALADRYWPEGKRFKPKEIVKEFEHTLLDELDLMREAANAAQLRRNFNQSPMLYIPEIYWDYCHHNIL
VIERIHGIPVTDIASLRDHGIDIKKLAERGVEIFFTQVFRDCFFHADMHPGNIFVSYQNPKDPQYICVDFGIIGTLTDND
KRYLAENLVAFFNRDYKRVAELHVESGWVSRDTPVAEFESSIRTVCEPIFEKPLKDISFGQVVFRLFQVARRFHMEVQPQ
LILLQKTLLAIEGLGRQLYPELDLWATAKPFLEKWVREQMGPKAFIKRLKQNLPFFTEQLPHMPKLIFDILEMKKDQLLT
VHELTRLQSENNNQTIQWKSMGLGVFFSFLSLGVISYFDLLDYNHLTTITIAGSVLAGIFVLINRKIRN

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=270, Percent_Identity=26.2962962962963, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI40254938, Length=274, Percent_Identity=27.7372262773723, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=27.6315789473684, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=25.6716417910448, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI34147522, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI2367309, Length=532, Percent_Identity=51.5037593984962, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17559152, Length=283, Percent_Identity=26.1484098939929, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32565180, Length=305, Percent_Identity=24.2622950819672, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=449, Percent_Identity=26.0579064587973, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323282, Length=254, Percent_Identity=27.5590551181102, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=293, Percent_Identity=24.9146757679181, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI22024280, Length=261, Percent_Identity=32.183908045977, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24662575, Length=277, Percent_Identity=27.7978339350181, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63674; Mature: 63674

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIKQLIRLIHINYILAKNGLDNVVVSIKLFAPLRFIVYLNPWNWLRKEKLTRGEALRK
CHHHHHHHHHHHHHHHHCCCCCCHHEEEEHHHHCEEEEEEECCHHHHHHHHHHHHHHHHH
SLEELGPIFIKFGQALSTRPDILPEDIAKELSKLQDKVPPFPSHIAMNIIEQAYKQSAYD
HHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VFAQFDPIALASASMAQVHAATLKTGENVVVKILRPNMRRLIEQDLSIMYTIAALADRYW
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
PEGKRFKPKEIVKEFEHTLLDELDLMREAANAAQLRRNFNQSPMLYIPEIYWDYCHHNIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCEE
VIERIHGIPVTDIASLRDHGIDIKKLAERGVEIFFTQVFRDCFFHADMHPGNIFVSYQNP
EEEEECCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
KDPQYICVDFGIIGTLTDNDKRYLAENLVAFFNRDYKRVAELHVESGWVSRDTPVAEFES
CCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SIRTVCEPIFEKPLKDISFGQVVFRLFQVARRFHMEVQPQLILLQKTLLAIEGLGRQLYP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHCC
ELDLWATAKPFLEKWVREQMGPKAFIKRLKQNLPFFTEQLPHMPKLIFDILEMKKDQLLT
CCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCHHHHHH
VHELTRLQSENNNQTIQWKSMGLGVFFSFLSLGVISYFDLLDYNHLTTITIAGSVLAGIF
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEHEEEHHHHHHHHH
VLINRKIRN
HHHHHHHCC
>Mature Secondary Structure
MKSIKQLIRLIHINYILAKNGLDNVVVSIKLFAPLRFIVYLNPWNWLRKEKLTRGEALRK
CHHHHHHHHHHHHHHHHCCCCCCHHEEEEHHHHCEEEEEEECCHHHHHHHHHHHHHHHHH
SLEELGPIFIKFGQALSTRPDILPEDIAKELSKLQDKVPPFPSHIAMNIIEQAYKQSAYD
HHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VFAQFDPIALASASMAQVHAATLKTGENVVVKILRPNMRRLIEQDLSIMYTIAALADRYW
HHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHC
PEGKRFKPKEIVKEFEHTLLDELDLMREAANAAQLRRNFNQSPMLYIPEIYWDYCHHNIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHCCCEE
VIERIHGIPVTDIASLRDHGIDIKKLAERGVEIFFTQVFRDCFFHADMHPGNIFVSYQNP
EEEEECCCCHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
KDPQYICVDFGIIGTLTDNDKRYLAENLVAFFNRDYKRVAELHVESGWVSRDTPVAEFES
CCCCEEEEEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
SIRTVCEPIFEKPLKDISFGQVVFRLFQVARRFHMEVQPQLILLQKTLLAIEGLGRQLYP
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHCC
ELDLWATAKPFLEKWVREQMGPKAFIKRLKQNLPFFTEQLPHMPKLIFDILEMKKDQLLT
CCCHHCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHCHHHHHH
VHELTRLQSENNNQTIQWKSMGLGVFFSFLSLGVISYFDLLDYNHLTTITIAGSVLAGIF
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEHEEEHHHHHHHHH
VLINRKIRN
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA