Definition Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome.
Accession NC_002942
Length 3,397,754

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The map label for this gene is gra-orf6 [H]

Identifier: 52843058

GI number: 52843058

Start: 3239928

End: 3240707

Strand: Reverse

Name: gra-orf6 [H]

Synonym: lpg2863

Alternate gene names: 52843058

Gene position: 3240707-3239928 (Counterclockwise)

Preceding gene: 52843063

Following gene: 52843057

Centisome position: 95.38

GC content: 43.21

Gene sequence:

>780_bases
CTGTTACCATATGGGGAACGTACCTTGAATCAGACAAACACGCAAGAAGCCAAGGTTGCTTTAGTGACTGGAGGCGCTAA
ACGTATCGGCGCAGCAATTGTTAAAAAATTACATCTCTCTGGATATCAGGTAGCCATCCATTGTCGTTCTGCTTTGCATG
AAGCCGATATTCTGGCCAAAGATTTGAATCGGTTGCGTACGAATAGCGCCATTGTCATGCAAAAAGAATTAACTGAGCCT
GATGCAGCAGAAGAGATCATATCCAAAGTGAAACATTGGGCCGGTCGTTTGGATTTGCTAGTGAATAATGCTTCTGCTTT
TAAACGAACGGATTGCCATTTATTGAATGAGGCAGACTGGCAATATCTGTTTGCAGTGAATGTCCAGGCTCCCTTTCTAC
TGAGTATGGCAGCTTGTCCTTTACTGGCTCCATGCAAGGGTTCCATTATTAACATAACTGATATTCATGCAGATAAGCCA
CTTAAAGGATATTCGGTATATTGTCAAACTAAAGCCGCATTGGAGATGCAAACGAGGTCGCTTGCTCGTGAGCTAGCACC
AGAAATAAGAGTCAATGCCGTTGCGCCTGGCGCCATTGCCTGGCCTGAGAATGACAATAGTTTAACTGCGGAAGCACAAC
AAAAAATTATCGAGAAAACACCGTTAAAAAGCCATGGCAAACCCGATTTTATTGCTCAGGCTGTTCTTGCTCTGGCTGAA
AATTCATTTATCACTGGTCAAACATTGAAAGTAGATGGAGGTAGAAGTTTGACAAGCTAA

Upstream 100 bases:

>100_bases
TGCGAGGAGAAACAAAGAAAATACTGAAGTGTACACAATAATACTTGAGGATTCGAGCATCCTGGCTGATTACTTTTTGC
AGTGAGGTTGCGAAAGGAGT

Downstream 100 bases:

>100_bases
AATTTTTCGTAAATCCTGAATCATTGGATCTACTGCATTTTAGGTTATTAACTGTTCTTTGTGATTTGTTTTAACCCACT
TTACTGCTTATAATATAACC

Product: pteridine reductase

Products: NA

Alternate protein names: ORF6 [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVMQKELTEP
DAAEEIISKVKHWAGRLDLLVNNASAFKRTDCHLLNEADWQYLFAVNVQAPFLLSMAACPLLAPCKGSIINITDIHADKP
LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE
NSFITGQTLKVDGGRSLTS

Sequences:

>Translated_259_residues
MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVMQKELTEP
DAAEEIISKVKHWAGRLDLLVNNASAFKRTDCHLLNEADWQYLFAVNVQAPFLLSMAACPLLAPCKGSIINITDIHADKP
LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE
NSFITGQTLKVDGGRSLTS
>Mature_259_residues
MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAKDLNRLRTNSAIVMQKELTEP
DAAEEIISKVKHWAGRLDLLVNNASAFKRTDCHLLNEADWQYLFAVNVQAPFLLSMAACPLLAPCKGSIINITDIHADKP
LKGYSVYCQTKAALEMQTRSLARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE
NSFITGQTLKVDGGRSLTS

Specific function: Unknown

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=32.046332046332, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=31.6205533596838, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=32.3886639676113, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=29.718875502008, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7705925, Length=241, Percent_Identity=31.1203319502075, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI5031737, Length=244, Percent_Identity=29.9180327868852, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI33667109, Length=184, Percent_Identity=33.1521739130435, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31542939, Length=258, Percent_Identity=25.968992248062, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI10190704, Length=248, Percent_Identity=28.2258064516129, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=28.0632411067194, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI66933014, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788459, Length=254, Percent_Identity=33.8582677165354, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=32.6612903225806, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI2367365, Length=241, Percent_Identity=30.7053941908714, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1789378, Length=263, Percent_Identity=32.6996197718631, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082160, Length=247, Percent_Identity=30.3643724696356, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1787891, Length=240, Percent_Identity=28.3333333333333, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=26.8, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=30.8300395256917, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI87082100, Length=258, Percent_Identity=28.2945736434109, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI2367175, Length=249, Percent_Identity=26.9076305220884, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=31.3253012048193, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786812, Length=179, Percent_Identity=33.5195530726257, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=249, Percent_Identity=30.5220883534137, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI115534694, Length=249, Percent_Identity=34.9397590361446, Blast_Score=103, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=30.2788844621514, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.6992481203008, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=30.1960784313725, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=260, Percent_Identity=31.5384615384615, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=30.9160305343511, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=31.6981132075472, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI72000259, Length=264, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=278, Percent_Identity=30.2158273381295, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=263, Percent_Identity=30.0380228136882, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=32.1285140562249, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=267, Percent_Identity=29.9625468164794, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562990, Length=264, Percent_Identity=31.0606060606061, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=243, Percent_Identity=30.0411522633745, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562906, Length=262, Percent_Identity=29.3893129770992, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17544670, Length=272, Percent_Identity=27.2058823529412, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560150, Length=271, Percent_Identity=30.2583025830258, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=30.6818181818182, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=30.0395256916996, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17531453, Length=265, Percent_Identity=30.9433962264151, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=29.6, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=262, Percent_Identity=29.0076335877863, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=31.1787072243346, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=263, Percent_Identity=27.7566539923954, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17508651, Length=256, Percent_Identity=28.515625, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=270, Percent_Identity=30, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=27.0161290322581, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.4878048780488, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=30.6451612903226, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=30.6451612903226, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357041, Length=246, Percent_Identity=30.4878048780488, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=31.3253012048193, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24643142, Length=246, Percent_Identity=30.4878048780488, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644337, Length=192, Percent_Identity=32.8125, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=25.7936507936508, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28189; Mature: 28189

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAK
CCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH
DLNRLRTNSAIVMQKELTEPDAAEEIISKVKHWAGRLDLLVNNASAFKRTDCHLLNEADW
HHHHHHCCCEEEEEHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCEECCCCC
QYLFAVNVQAPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRS
EEEEEEECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHH
LARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE
HHHHHCCHHEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
NSFITGQTLKVDGGRSLTS
CCEECCCEEEECCCCCCCC
>Mature Secondary Structure
MLPYGERTLNQTNTQEAKVALVTGGAKRIGAAIVKKLHLSGYQVAIHCRSALHEADILAK
CCCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHH
DLNRLRTNSAIVMQKELTEPDAAEEIISKVKHWAGRLDLLVNNASAFKRTDCHLLNEADW
HHHHHHCCCEEEEEHHCCCCHHHHHHHHHHHHHHCCEEEEEECCCHHHCCCCCEECCCCC
QYLFAVNVQAPFLLSMAACPLLAPCKGSIINITDIHADKPLKGYSVYCQTKAALEMQTRS
EEEEEEECCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHHHHHHH
LARELAPEIRVNAVAPGAIAWPENDNSLTAEAQQKIIEKTPLKSHGKPDFIAQAVLALAE
HHHHHCCHHEEEEECCCCEECCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
NSFITGQTLKVDGGRSLTS
CCEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2583128; 9831526 [H]