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The map label for this gene is folE2

Identifier: 52842965

GI number: 52842965

Start: 3116053

End: 3116619

Strand: Direct

Name: folE2

Synonym: lpg2766

Alternate gene names: 52842965

Gene position: 3116053-3116619 (Clockwise)

Preceding gene: 52842964

Following gene: 52842990

Centisome position: 91.71

GC content: 38.8

Gene sequence:

>567_bases
TTGGCCGCCAGGTTAGGAATTCTTGCTATGGAAAAATTATACTCAAATTTGCTTAAAGAATTAGGCGAAGATATAAATCG
GGAAGGATTAAAGGATACTCCTGGACGAGCAGCTAATGCCTTACGTTATTTAACTAAAGGTTACAATGAGAACCTTGATG
AAATCATTAACGGTGCTCTGTTTGATTCAGACATGAGTGAAATGGTTATCGTCAAGGACATAGAACTGTACTCATTATGC
GAACATCACTTATTGCCTTTTTTGGGTAAATGCCATGTTGGATATCTACCTGATGGTAAAGTAATAGGCTTATCTAAAAT
TGCTCGTATTGTTGATTTTTATGCGAGGAGACTACAAATTCAAGAACGGCTGACGGGCGAAATTGCTCACTGTATTGAAT
CCACTACCGGAGCTCGCGGTGTCGCCGTAGTGATTGAAGCAAAACATCTTTGCATGATGATGCGTGGAGTTGAAAAACAA
AATTCTGTCATGACAACTTCAGTTATGCTCGGTGAAATGCGTAACAATTCGAGCTGCCGTTTGGAATTCTTAAATTTAAT
TCGTTAA

Upstream 100 bases:

>100_bases
TAAGTGAAATGGGTTATCGATTGGTTTTTAATGTTAATTCTGGTGGCGGGCAGGAAGTTTACCACATTCATTTACATTTA
CTTGGCGGGCGTCAAATGAC

Downstream 100 bases:

>100_bases
TACTGATAAGAAATAGGTAGGGGCTTTATCCCCGCCTATAATAAAATAACTGCTCCATTTACTGCTGATAGCTAACCCGA
TATATTACATTAGCATAATC

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 188; Mature: 187

Protein sequence:

>188_residues
MAARLGILAMEKLYSNLLKELGEDINREGLKDTPGRAANALRYLTKGYNENLDEIINGALFDSDMSEMVIVKDIELYSLC
EHHLLPFLGKCHVGYLPDGKVIGLSKIARIVDFYARRLQIQERLTGEIAHCIESTTGARGVAVVIEAKHLCMMMRGVEKQ
NSVMTTSVMLGEMRNNSSCRLEFLNLIR

Sequences:

>Translated_188_residues
MAARLGILAMEKLYSNLLKELGEDINREGLKDTPGRAANALRYLTKGYNENLDEIINGALFDSDMSEMVIVKDIELYSLC
EHHLLPFLGKCHVGYLPDGKVIGLSKIARIVDFYARRLQIQERLTGEIAHCIESTTGARGVAVVIEAKHLCMMMRGVEKQ
NSVMTTSVMLGEMRNNSSCRLEFLNLIR
>Mature_187_residues
AARLGILAMEKLYSNLLKELGEDINREGLKDTPGRAANALRYLTKGYNENLDEIINGALFDSDMSEMVIVKDIELYSLCE
HHLLPFLGKCHVGYLPDGKVIGLSKIARIVDFYARRLQIQERLTGEIAHCIESTTGARGVAVVIEAKHLCMMMRGVEKQN
SVMTTSVMLGEMRNNSSCRLEFLNLIR

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=175, Percent_Identity=56.5714285714286, Blast_Score=222, Evalue=1e-58,
Organism=Homo sapiens, GI4503949, Length=175, Percent_Identity=56.5714285714286, Blast_Score=222, Evalue=1e-58,
Organism=Homo sapiens, GI66932972, Length=134, Percent_Identity=56.7164179104478, Blast_Score=174, Evalue=3e-44,
Organism=Homo sapiens, GI66932970, Length=143, Percent_Identity=53.8461538461538, Blast_Score=174, Evalue=4e-44,
Organism=Escherichia coli, GI1788476, Length=185, Percent_Identity=38.3783783783784, Blast_Score=111, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=174, Percent_Identity=59.1954022988506, Blast_Score=227, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321706, Length=173, Percent_Identity=57.2254335260116, Blast_Score=207, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24656791, Length=178, Percent_Identity=55.0561797752809, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24656796, Length=178, Percent_Identity=55.0561797752809, Blast_Score=199, Evalue=7e-52,
Organism=Drosophila melanogaster, GI24656782, Length=178, Percent_Identity=55.0561797752809, Blast_Score=199, Evalue=8e-52,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 21077; Mature: 20946

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
8.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARLGILAMEKLYSNLLKELGEDINREGLKDTPGRAANALRYLTKGYNENLDEIINGAL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
FDSDMSEMVIVKDIELYSLCEHHLLPFLGKCHVGYLPDGKVIGLSKIARIVDFYARRLQI
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHH
QERLTGEIAHCIESTTGARGVAVVIEAKHLCMMMRGVEKQNSVMTTSVMLGEMRNNSSCR
HHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCHH
LEFLNLIR
HHHHHHCC
>Mature Secondary Structure 
AARLGILAMEKLYSNLLKELGEDINREGLKDTPGRAANALRYLTKGYNENLDEIINGAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHH
FDSDMSEMVIVKDIELYSLCEHHLLPFLGKCHVGYLPDGKVIGLSKIARIVDFYARRLQI
CCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHH
QERLTGEIAHCIESTTGARGVAVVIEAKHLCMMMRGVEKQNSVMTTSVMLGEMRNNSSCR
HHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCCHH
LEFLNLIR
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA