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The map label for this gene is hemY

Identifier: 52842942

GI number: 52842942

Start: 3088490

End: 3089677

Strand: Direct

Name: hemY

Synonym: lpg2738

Alternate gene names: 52842942

Gene position: 3088490-3089677 (Clockwise)

Preceding gene: 52842941

Following gene: 52842947

Centisome position: 90.9

GC content: 38.13

Gene sequence:

>1188_bases
ATGATACGAGTTCTGTTTGCTTTTATTATTTTACTGCTCTCTGTGTTCCTTGGTATTCAACTCAATAAGGATCCAGGTTA
TGTCTTAATAGCTATTAATAACTGGACTATTGAAACTACCTTATGGGTCTCTGTTTTTGGCTTGTTTTTTCTGTTTTTTT
TAATCTATGGCCTGGTTCAGTTTTGCAATAAAATTACAAGAATGCCAGGCATGGTCAATAAATGGCACTCACGACGCTTG
GCACAAAAAGCTCAAGCCACGACTCGAAAGGGACTGATAGAATATAGCGAGGGCTATTGGCAAAAAGCAAAAAATCATTT
AATACAAGCTCTGCCAAACACCGACACTCCTTTACTTAATTATTTAACAGCAGCGAGAGCTGCTCAAAAAATGGGGGATA
GCAAGCTTCGCGATCATTATCTTAGGGAAGCACAGCAATCTATGCCCGAAGCGAAAATTGCTGTTGAATTAACCCAAGCG
CAATTACAATTGGCCAATCACCAATGGGAACAGGCATTGGCCACATTAAAGCATCTTCAAGATTTAGCACCACGCCATCC
TTATGTCTTGAAATTATTAATGAATCTTTATGAAGAAATAAAAGATTGGCAGCAGTTGATCGCTCTTTTACCTGATTTAA
AAAAGAACCACATTATTTCAGATCAAGCTTTTGAACAATTACAAAAAAATACTTATTTGCAAGCAATGATTGATTTGGCA
AAACACAATCAATCAGATGGCATTACCAAATTGTATCAGACGCTGCCAAAAACACTGGTTAACGATACTGCAATTACAGC
AGAATATGCCCGCTTTCTGATTAGGAATCAGGATTACGATCAGGCAGAATATCATTTAAAGCGATGCCTTCGCAAAGAGT
TGGATAATCGGTTAATTGAGCTTTATAGCCTGCTCCCTTGTGAAGAAAATCAATTGTTATTTGCTGAATCATTACTCAAA
AAAAATCCTCACTCAGCCGCATTGTACCTATGTTTAGGGAGAATGTGCCTCTCGCGGCATTTATGGGGAAAAGCCAAACA
TTATCTTGAACAGTCTATTGAGCTAAACCCCACGCCCGTAGCATTTATCGAACTTGGCAAACTCCATGAAAAGCTAAATG
ACCCCTTATCCAGTGGCTCTTGTTATAAAAAAGGTCTGGAGTTGATAACAAAAGATGAATTATCCTAA

Upstream 100 bases:

>100_bases
AACCTGTCGTAGGACAAGCCATCCCGCTAATCAATCAAATGATTGACAATAAAGAGTTGCTGGTCGATCAAGCAAACAGC
AAGAAAGGAGAAAATTAAGA

Downstream 100 bases:

>100_bases
TTGATTAAAAACTGAAAGACACAGCTCGAAATGCAAAGCAAAAAATGTTTTTAATAAGGGCGTTTAGATACAATTAATGA
ATAAATTAAACCTTTTTTTA

Product: protoporphyrinogen IX and coproporphyrinogen III oxidase HemY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIRVLFAFIILLLSVFLGIQLNKDPGYVLIAINNWTIETTLWVSVFGLFFLFFLIYGLVQFCNKITRMPGMVNKWHSRRL
AQKAQATTRKGLIEYSEGYWQKAKNHLIQALPNTDTPLLNYLTAARAAQKMGDSKLRDHYLREAQQSMPEAKIAVELTQA
QLQLANHQWEQALATLKHLQDLAPRHPYVLKLLMNLYEEIKDWQQLIALLPDLKKNHIISDQAFEQLQKNTYLQAMIDLA
KHNQSDGITKLYQTLPKTLVNDTAITAEYARFLIRNQDYDQAEYHLKRCLRKELDNRLIELYSLLPCEENQLLFAESLLK
KNPHSAALYLCLGRMCLSRHLWGKAKHYLEQSIELNPTPVAFIELGKLHEKLNDPLSSGSCYKKGLELITKDELS

Sequences:

>Translated_395_residues
MIRVLFAFIILLLSVFLGIQLNKDPGYVLIAINNWTIETTLWVSVFGLFFLFFLIYGLVQFCNKITRMPGMVNKWHSRRL
AQKAQATTRKGLIEYSEGYWQKAKNHLIQALPNTDTPLLNYLTAARAAQKMGDSKLRDHYLREAQQSMPEAKIAVELTQA
QLQLANHQWEQALATLKHLQDLAPRHPYVLKLLMNLYEEIKDWQQLIALLPDLKKNHIISDQAFEQLQKNTYLQAMIDLA
KHNQSDGITKLYQTLPKTLVNDTAITAEYARFLIRNQDYDQAEYHLKRCLRKELDNRLIELYSLLPCEENQLLFAESLLK
KNPHSAALYLCLGRMCLSRHLWGKAKHYLEQSIELNPTPVAFIELGKLHEKLNDPLSSGSCYKKGLELITKDELS
>Mature_395_residues
MIRVLFAFIILLLSVFLGIQLNKDPGYVLIAINNWTIETTLWVSVFGLFFLFFLIYGLVQFCNKITRMPGMVNKWHSRRL
AQKAQATTRKGLIEYSEGYWQKAKNHLIQALPNTDTPLLNYLTAARAAQKMGDSKLRDHYLREAQQSMPEAKIAVELTQA
QLQLANHQWEQALATLKHLQDLAPRHPYVLKLLMNLYEEIKDWQQLIALLPDLKKNHIISDQAFEQLQKNTYLQAMIDLA
KHNQSDGITKLYQTLPKTLVNDTAITAEYARFLIRNQDYDQAEYHLKRCLRKELDNRLIELYSLLPCEENQLLFAESLLK
KNPHSAALYLCLGRMCLSRHLWGKAKHYLEQSIELNPTPVAFIELGKLHEKLNDPLSSGSCYKKGLELITKDELS

Specific function: Involved in a late step of protoheme IX synthesis [H]

COG id: COG3071

COG function: function code H; Uncharacterized enzyme of heme biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Escherichia coli, GI1790234, Length=381, Percent_Identity=23.3595800524934, Blast_Score=131, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010817
- InterPro:   IPR005254
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR013105
- InterPro:   IPR019734 [H]

Pfam domain/function: PF07219 HemY_N; PF07719 TPR_2 [H]

EC number: NA

Molecular weight: Translated: 45693; Mature: 45693

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVLFAFIILLLSVFLGIQLNKDPGYVLIAINNWTIETTLWVSVFGLFFLFFLIYGLVQ
CHHHHHHHHHHHHHHHHCCEECCCCCEEEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHH
FCNKITRMPGMVNKWHSRRLAQKAQATTRKGLIEYSEGYWQKAKNHLIQALPNTDTPLLN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YLTAARAAQKMGDSKLRDHYLREAQQSMPEAKIAVELTQAQLQLANHQWEQALATLKHLQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAPRHPYVLKLLMNLYEEIKDWQQLIALLPDLKKNHIISDQAFEQLQKNTYLQAMIDLA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KHNQSDGITKLYQTLPKTLVNDTAITAEYARFLIRNQDYDQAEYHLKRCLRKELDNRLIE
HCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYSLLPCEENQLLFAESLLKKNPHSAALYLCLGRMCLSRHLWGKAKHYLEQSIELNPTPV
HHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AFIELGKLHEKLNDPLSSGSCYKKGLELITKDELS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIRVLFAFIILLLSVFLGIQLNKDPGYVLIAINNWTIETTLWVSVFGLFFLFFLIYGLVQ
CHHHHHHHHHHHHHHHHCCEECCCCCEEEEEEECCEEHHHHHHHHHHHHHHHHHHHHHHH
FCNKITRMPGMVNKWHSRRLAQKAQATTRKGLIEYSEGYWQKAKNHLIQALPNTDTPLLN
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
YLTAARAAQKMGDSKLRDHYLREAQQSMPEAKIAVELTQAQLQLANHQWEQALATLKHLQ
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLAPRHPYVLKLLMNLYEEIKDWQQLIALLPDLKKNHIISDQAFEQLQKNTYLQAMIDLA
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHH
KHNQSDGITKLYQTLPKTLVNDTAITAEYARFLIRNQDYDQAEYHLKRCLRKELDNRLIE
HCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
LYSLLPCEENQLLFAESLLKKNPHSAALYLCLGRMCLSRHLWGKAKHYLEQSIELNPTPV
HHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AFIELGKLHEKLNDPLSSGSCYKKGLELITKDELS
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]