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The map label for this gene is pth

Identifier: 52842859

GI number: 52842859

Start: 2999713

End: 3000282

Strand: Direct

Name: pth

Synonym: lpg2653

Alternate gene names: 52842859

Gene position: 2999713-3000282 (Clockwise)

Preceding gene: 52842858

Following gene: 52842860

Centisome position: 88.29

GC content: 39.82

Gene sequence:

>570_bases
ATGGTCATTAAACTAATTGTCGGTTTACGCAATCCCGGATCGGCTTATGAACAAACCAGACACAACGCAGGTGCGTGGTT
AGTGACCGCTTTGGCCCAAAGACATAATTCGCATTTTAAGATTGACAAGAAAATGCAAGCGGAATTAACTGAAATTGATA
TTAACAACCACCCATGTCGACTAGTGCTTCCTTTGACTTTTATGAATCATAGTGGTCAAACAACAAGAATAATCAGTCAA
TTCTATAAAATTGAACCCGGTGAAATATTAATTGTTCATGACGAGTTGGATTTACCTGTTGGACGAATCAAATTAAAAAC
AGGTGGTGGCCATGGTGGGCATAATGGTTTGAGAGACATAACTGCTCAATTGGGAACAGGTGAATTTCATCGATTACGTA
TAGGGATAGGTCATCCTGGACATAAAGATCTAGTCCATCAATACGTACTCAGCAGGCCTTCTATGCACGACAGGCAACAA
ATTTATGATGCAATAGACAGAGGTATAGCGATAATACCTATAGTATTGTCAGGGGATATGGCCCGAGCAATGAATCAAGT
AAACGCTTAA

Upstream 100 bases:

>100_bases
TTTATGCAAATATTCAGAGCTTAACCCAGAATATTTGCATAAAATCTAGTGCTAGAATAGTTAACACAAATCCGCTTAAT
TCAAATTTTATAGAAAATCT

Downstream 100 bases:

>100_bases
CATAATGAGGTATGACTCATGGGATTTAAATGTGGAATAGTAGGATTGCCCAATGTAGGGAAATCGACTCTTTTTAATGC
ATTGACTAAGGCTGGGATAG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MVIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLVLPLTFMNHSGQTTRIISQ
FYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQ
IYDAIDRGIAIIPIVLSGDMARAMNQVNA

Sequences:

>Translated_189_residues
MVIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLVLPLTFMNHSGQTTRIISQ
FYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQ
IYDAIDRGIAIIPIVLSGDMARAMNQVNA
>Mature_189_residues
MVIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCRLVLPLTFMNHSGQTTRIISQ
FYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDITAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQ
IYDAIDRGIAIIPIVLSGDMARAMNQVNA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=32.3529411764706, Blast_Score=95, Evalue=3e-20,
Organism=Escherichia coli, GI1787455, Length=190, Percent_Identity=46.3157894736842, Blast_Score=157, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21063; Mature: 21063

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCR
CEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHCEEEEEECCCCCEE
LVLPLTFMNHSGQTTRIISQFYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDI
EEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHH
TAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQIYDAIDRGIAIIPIVLSGDM
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCHH
ARAMNQVNA
HHHHHHCCC
>Mature Secondary Structure
MVIKLIVGLRNPGSAYEQTRHNAGAWLVTALAQRHNSHFKIDKKMQAELTEIDINNHPCR
CEEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHCEEEEEECCCCCEE
LVLPLTFMNHSGQTTRIISQFYKIEPGEILIVHDELDLPVGRIKLKTGGGHGGHNGLRDI
EEEEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEEEEEECCCCCCCCCHHHH
TAQLGTGEFHRLRIGIGHPGHKDLVHQYVLSRPSMHDRQQIYDAIDRGIAIIPIVLSGDM
HHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEEEEECCHH
ARAMNQVNA
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA