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The map label for this gene is ttdR [H]

Identifier: 52842592

GI number: 52842592

Start: 2689113

End: 2690039

Strand: Direct

Name: ttdR [H]

Synonym: lpg2383

Alternate gene names: 52842592

Gene position: 2689113-2690039 (Clockwise)

Preceding gene: 52842591

Following gene: 52842593

Centisome position: 79.14

GC content: 34.52

Gene sequence:

>927_bases
ATGAATATTTTATCCTGTTTGAAAGGCTTTATTGCAACCGTTGATTGCAAAAGTTTTTCAAAGGCCGCACAAAAATTATA
TATATCCCCCTCTAAATTAAGCAAACAAATAACTTGGCTGGAGGAGGAATTAAAAGTTACCTTGTTGATACGCTCTACAA
CACGATTAATTGTGACTGAATCAGGCCATAGGTTGTATGAAAAGGCTTTAGATCTTTTCGAGCAATTAGAGGTAGTCAAG
GTCATTGCAACGCCCGATCAGTTCGAATTAAATGGCATAATCAGGCTCTATCTTACTGTTACTCCGGCAATTCCCTACTT
AACCTCATTAAGTATTCAATTTATGCGTAAATATCCCGGGATTGAAATAGATTTTATTGTTGGTTCGGATACAAAAGAGC
TCTACTCCTCTACCTTTGATCTGGCTATTTCATTTGATGATGTCAAACATGCAAAACTGGTTTGCAAAAGATTATTTTCA
ATCCAGAGAAATGTCTTTGCTTCACCTGATTATATCACTCAATATGGGCTTCCTCAGACAATCGACGAACTACCAAAGCA
TAATTGTTTGATTAACACTCTCTATGGCCTGCAAAATAAATGGGTTTTTAACAAAAAAATCATTCATGTCTCGGGAAATT
TTAAAAGCAATAATGCGGGTGTTTTAAAACAAGCTGCGGTTGCAGGCCTAGGACTTCTATTGGCTCCTTATTTTTCAGTT
TATGAAGAAATAAAAAATGAAGCATTAATTCAGGTACTACCCCATAAATCTTCACCAGATATCAATCTTTATGCCATTTA
CCCAAAGTCTATAATGGATGAACAAAAAATTAATTTACTTTTGAACTTTTTTGTGAAAAGGCCTTGTCAGAAAACATTGC
GACATCCTTTATTGATGAAAATAATTAAAGATGGATCAGTAATTTAA

Upstream 100 bases:

>100_bases
CAAATCAGCTTTCTCTGTCAGGAAATCATTGTTGTTGATTTACAAAACTGTCATCCAGGTCTATACCATTTAAAAAGAGT
TCAATTAAGAAAATTTCAAG

Downstream 100 bases:

>100_bases
TCTATTTTCTATTGCAAATTCAAAGAATTAGATTAATTTATCTAAGATTAAAGTGGCACTTATTGGAGGATAACCCCTCC
TTTTGAGCAAAGATAAATTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNILSCLKGFIATVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLIVTESGHRLYEKALDLFEQLEVVK
VIATPDQFELNGIIRLYLTVTPAIPYLTSLSIQFMRKYPGIEIDFIVGSDTKELYSSTFDLAISFDDVKHAKLVCKRLFS
IQRNVFASPDYITQYGLPQTIDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVAGLGLLLAPYFSV
YEEIKNEALIQVLPHKSSPDINLYAIYPKSIMDEQKINLLLNFFVKRPCQKTLRHPLLMKIIKDGSVI

Sequences:

>Translated_308_residues
MNILSCLKGFIATVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLIVTESGHRLYEKALDLFEQLEVVK
VIATPDQFELNGIIRLYLTVTPAIPYLTSLSIQFMRKYPGIEIDFIVGSDTKELYSSTFDLAISFDDVKHAKLVCKRLFS
IQRNVFASPDYITQYGLPQTIDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVAGLGLLLAPYFSV
YEEIKNEALIQVLPHKSSPDINLYAIYPKSIMDEQKINLLLNFFVKRPCQKTLRHPLLMKIIKDGSVI
>Mature_308_residues
MNILSCLKGFIATVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLIVTESGHRLYEKALDLFEQLEVVK
VIATPDQFELNGIIRLYLTVTPAIPYLTSLSIQFMRKYPGIEIDFIVGSDTKELYSSTFDLAISFDDVKHAKLVCKRLFS
IQRNVFASPDYITQYGLPQTIDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVAGLGLLLAPYFSV
YEEIKNEALIQVLPHKSSPDINLYAIYPKSIMDEQKINLLLNFFVKRPCQKTLRHPLLMKIIKDGSVI

Specific function: Positive regulator required for L-tartrate-dependent anaerobic growth on glycerol. Induces expression of the ttdA-ttdB- ygjE operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=295, Percent_Identity=28.4745762711864, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786401, Length=284, Percent_Identity=27.112676056338, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87081978, Length=294, Percent_Identity=27.5510204081633, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI145693193, Length=291, Percent_Identity=25.085910652921, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789639, Length=302, Percent_Identity=27.8145695364238, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1787589, Length=273, Percent_Identity=25.2747252747253, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787128, Length=302, Percent_Identity=24.5033112582781, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788706, Length=181, Percent_Identity=32.5966850828729, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790208, Length=144, Percent_Identity=29.1666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789173, Length=251, Percent_Identity=25.4980079681275, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786448, Length=268, Percent_Identity=24.6268656716418, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34994; Mature: 34994

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILSCLKGFIATVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLIVTE
CCHHHHHHHHHHHHCHHHHHHHHHHEECCHHHHHHHHHHHHHCCEEEEEEECCEEEEEEC
SGHRLYEKALDLFEQLEVVKVIATPDQFELNGIIRLYLTVTPAIPYLTSLSIQFMRKYPG
CCHHHHHHHHHHHHHHHHHHEEECCCCEECCCEEEEEEEECCHHHHHHHHHHHHHHHCCC
IEIDFIVGSDTKELYSSTFDLAISFDDVKHAKLVCKRLFSIQRNVFASPDYITQYGLPQT
CEEEEEECCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHH
IDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVAGLGLLLAPYFSV
HHHCCCCCCHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YEEIKNEALIQVLPHKSSPDINLYAIYPKSIMDEQKINLLLNFFVKRPCQKTLRHPLLMK
HHHHCCCEEEEEECCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
IIKDGSVI
HHHCCCCC
>Mature Secondary Structure
MNILSCLKGFIATVDCKSFSKAAQKLYISPSKLSKQITWLEEELKVTLLIRSTTRLIVTE
CCHHHHHHHHHHHHCHHHHHHHHHHEECCHHHHHHHHHHHHHCCEEEEEEECCEEEEEEC
SGHRLYEKALDLFEQLEVVKVIATPDQFELNGIIRLYLTVTPAIPYLTSLSIQFMRKYPG
CCHHHHHHHHHHHHHHHHHHEEECCCCEECCCEEEEEEEECCHHHHHHHHHHHHHHHCCC
IEIDFIVGSDTKELYSSTFDLAISFDDVKHAKLVCKRLFSIQRNVFASPDYITQYGLPQT
CEEEEEECCCHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHH
IDELPKHNCLINTLYGLQNKWVFNKKIIHVSGNFKSNNAGVLKQAAVAGLGLLLAPYFSV
HHHCCCCCCHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
YEEIKNEALIQVLPHKSSPDINLYAIYPKSIMDEQKINLLLNFFVKRPCQKTLRHPLLMK
HHHHCCCEEEEEECCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
IIKDGSVI
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]