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The map label for this gene is ispA

Identifier: 52842540

GI number: 52842540

Start: 2633671

End: 2634600

Strand: Direct

Name: ispA

Synonym: lpg2330

Alternate gene names: 52842540

Gene position: 2633671-2634600 (Clockwise)

Preceding gene: 52842539

Following gene: 52842542

Centisome position: 77.51

GC content: 40.97

Gene sequence:

>930_bases
CTGGTACTGATTCCAACATTGAACTCGACTCAGATGAACAAACAAGTGATTGATAAGTATACCCAAAGACATGAGCTATA
TCTCGAGCAATTGCTCAATGAAATAATAATACCAGCTCCCCAAATTCGCTCCGCACTCCATTACGCTTTATTTTCAGGCG
GCAAAAGAATAAGACCCATTTTGGTTTATTTGGCTGGCGATTTAATTGATGTTGACCAGGGAGTTCTGGATATTATTGCG
GCAGCGCTTGAGTTAACACATTGCTATTCCCTGATTCATGATGATCTTCCAGCGATGGACAATGACGATCTGCGCCGCGG
TAAGCCGAGTTGTCATAAAGCATTTGATGAGGCAACCGCTATTTTAGTCGGCGATGGCATGCAAGCTTTAGCGATTGAAG
TCTTACTGATGAGATTATCGCCCCTTCTCCCCGCAGCACAAGTCGTAGCCATTACTCAAGTATTGGTAAATGCCAGTGGA
ATAAGTGGAATGGTTAGTGGCCAAAGTCTTGATTTATCAGAACTGGCCAAATCATCGGTAACTGAGGAGCAATTAAGAGA
AATTCATCTTTTGAAAACTGGAAAACTGATCCTGGCGTGTTTTGAAATGGTTTTAGCAGCACAACATGAGGTATCTGAGC
AAATCAAATCCGCACTAAGAACTTATGGGAAACATATAGGGCTTGTATTTCAAATGCAAGATGATTACCTGGATCTGTAC
GCTCCAACTCAAATATTGGGAAAAGGTCGCTCCTCGGATCAGGCAAACCAAAAAACCACTTTTGCAACCTTATTTAACAA
GCAACAATTGGAAGAAGAAATCGCTGTTCATTACCAAATTGCAATGGATTCTCTGCGGTTATTTGGTAGTAAAGCGGCTG
CATTAATTGAATTAACAAAACAATTACAAAATCGTAGCAATTTGTCTTGA

Upstream 100 bases:

>100_bases
AGCCTTGAAGAATCGCTGAAACAATTTGAAAAGGGAATTAGCCTTGCAAGACGTTGCCAAAATGCTTTGAATCAGGCAGA
GCAAAAAATTGAAACGTTAA

Downstream 100 bases:

>100_bases
CACCATTGATGCACCGGACAATCCGATTGATATCCGTTTTAAATTAGGATTTTTTAACAACACGCGAAACAGGAATCCAG
GTTTCTATACCTTGCTCCAT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIA
AALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASG
ISGMVSGQSLDLSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLY
APTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS

Sequences:

>Translated_309_residues
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIA
AALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASG
ISGMVSGQSLDLSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLY
APTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS
>Mature_309_residues
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPILVYLAGDLIDVDQGVLDIIA
AALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATAILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASG
ISGMVSGQSLDLSELAKSSVTEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLY
APTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTKQLQNRSNLS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=261, Percent_Identity=29.1187739463602, Blast_Score=78, Evalue=8e-15,
Organism=Escherichia coli, GI1786623, Length=248, Percent_Identity=41.5322580645161, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1789578, Length=220, Percent_Identity=30.4545454545455, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651612, Length=244, Percent_Identity=26.2295081967213, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 34162; Mature: 34162

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
LVYLAGDLIDVDQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHE
ILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKSSV
EEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCC
TEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHH
APTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTK
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLQNRSNLS
HHHHCCCCC
>Mature Secondary Structure
MVLIPTLNSTQMNKQVIDKYTQRHELYLEQLLNEIIIPAPQIRSALHYALFSGGKRIRPI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHH
LVYLAGDLIDVDQGVLDIIAAALELTHCYSLIHDDLPAMDNDDLRRGKPSCHKAFDEATA
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHE
ILVGDGMQALAIEVLLMRLSPLLPAAQVVAITQVLVNASGISGMVSGQSLDLSELAKSSV
EEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHCC
TEEQLREIHLLKTGKLILACFEMVLAAQHEVSEQIKSALRTYGKHIGLVFQMQDDYLDLY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHH
APTQILGKGRSSDQANQKTTFATLFNKQQLEEEIAVHYQIAMDSLRLFGSKAAALIELTK
CCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLQNRSNLS
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]