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The map label for this gene is lolC [H]

Identifier: 52842498

GI number: 52842498

Start: 2586626

End: 2587981

Strand: Reverse

Name: lolC [H]

Synonym: lpg2285

Alternate gene names: 52842498

Gene position: 2587981-2586626 (Counterclockwise)

Preceding gene: 52842499

Following gene: 52842497

Centisome position: 76.17

GC content: 37.39

Gene sequence:

>1356_bases
TTGTCTGATGATGAATTATTAATAAGTTCTTTAAAATCTTTAGGCTTCAATCTTGGCCTTTTCTATAAGTACTGTACAAT
ACTAACTTTAATCCAGCTGAATACGATTATGTATAAACCATTGGCTCTGTTTATCGGATTACGTTATACGCGTTCACGTA
AGAAAAATCACTTTGTTTCCTTTATTTCCTTAAGTTCCATGTTGGGTATAGGCATGGGAGTGATGGTTTTAATCACTGTT
TTATCAGTGATGAATGGTTTTGATCAGGAAATTCATCGTCGTTTTTTTGGGATGGCGCCTGAAATCACCATAACAGGTCC
TGATGAGCGATTAAGTGATTGGCCTGAAGTGGTTAAAAAGGTTGAAACAATTCCTGGAATAAAGGCAATTGCGCCTTATG
TTGGAAGTCAAGGATTATTAACTCATGAAGGCCAGGTTTTGCCTATCGTTCTAACCGGTATTTTGCCAGAGAAAGAACAA
TCAGTAACTCATCTCAATAAGAAACTACTGGCAGGTAATATGAGTAATCTGAAACATTTTGGGATTATTCTCGGAAAAGG
TCTTGCGGACAGCCTTGGAGTGATGATTGGGGATAAGGTTACGATAATGATCCCGCAAGCAACAGTAACTCCTGCCGGTA
TGATCCCTCGATTCAAGCGCTTTACCGTTGTAGGTGTTTTTTCTGCTGGTACAGGATTTAATTTCGATACTAAATTGGCA
TTTATTAATATCGAAGATGCTCAAAAATTAATGCAAATGGATAAGAATGACGTTTCAGGTATAAAAATGAAAATTAATAA
TGTATACAAAGCACCTGAATTGTCTTATGAATTATCCGATCTTTTGGGAGAAGGATATCAAGTAGGCAATTGGACCCAAC
AATTTGGAGCTTTTTTTGAAGCAGTTAAAATGGAAAAAACGATGATGTTTATGATTTTATTGCTTATTATTGCTGTGGCT
GCTTTTAATTTGGTGTCCTCTCTGGTAATGGTAGTCAATGACAAACAAGCTGAAATTGCCATTTTAAGAACTATTGGCGC
TACTCCTTCTACCATTTTATGGGTTTTTATTGTACAGGGAATGATGGTTGGTCTGGTTGGTACAATTCTCGGGCTGTTAG
GAGGTTTAGTGTTGGCCAATAATGCAACGGAGATAGTTAATGCATTGCAGTCCTTTTTCCAGGTGAAGGTGTTGTCTTCA
AGCATCTATTTTGTTGATTACTTGCCTTCTAAAATTATGTTTCGTGATCTGTGGCAAGTTTGTGCTATGGCATTATTAAT
GAGTTTTGCTGCAACTATTTATCCTGCCTGGCGAGCATCAAAGACAGTCATCGCGGAGGCTTTGCATTATGAATGA

Upstream 100 bases:

>100_bases
AAGTCTACTAGATGACTATTTAAAAAGGATTTCCCCAAAACACATGATTATGAAATCCTAGCTATTAGTTATCCACAGAT
TCTGTGGATAACTATGTGGG

Downstream 100 bases:

>100_bases
CATCATTTTAACCAGTCAAAAACTGTATAAGTCCTACCATGATGGCACTTCAACAGTTGAGGTGTTAAAAGGAGTGGACT
TGGCCATAACAAAAGGGGAC

Product: lipoprotein ABC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSDDELLISSLKSLGFNLGLFYKYCTILTLIQLNTIMYKPLALFIGLRYTRSRKKNHFVSFISLSSMLGIGMGVMVLITV
LSVMNGFDQEIHRRFFGMAPEITITGPDERLSDWPEVVKKVETIPGIKAIAPYVGSQGLLTHEGQVLPIVLTGILPEKEQ
SVTHLNKKLLAGNMSNLKHFGIILGKGLADSLGVMIGDKVTIMIPQATVTPAGMIPRFKRFTVVGVFSAGTGFNFDTKLA
FINIEDAQKLMQMDKNDVSGIKMKINNVYKAPELSYELSDLLGEGYQVGNWTQQFGAFFEAVKMEKTMMFMILLLIIAVA
AFNLVSSLVMVVNDKQAEIAILRTIGATPSTILWVFIVQGMMVGLVGTILGLLGGLVLANNATEIVNALQSFFQVKVLSS
SIYFVDYLPSKIMFRDLWQVCAMALLMSFAATIYPAWRASKTVIAEALHYE

Sequences:

>Translated_451_residues
MSDDELLISSLKSLGFNLGLFYKYCTILTLIQLNTIMYKPLALFIGLRYTRSRKKNHFVSFISLSSMLGIGMGVMVLITV
LSVMNGFDQEIHRRFFGMAPEITITGPDERLSDWPEVVKKVETIPGIKAIAPYVGSQGLLTHEGQVLPIVLTGILPEKEQ
SVTHLNKKLLAGNMSNLKHFGIILGKGLADSLGVMIGDKVTIMIPQATVTPAGMIPRFKRFTVVGVFSAGTGFNFDTKLA
FINIEDAQKLMQMDKNDVSGIKMKINNVYKAPELSYELSDLLGEGYQVGNWTQQFGAFFEAVKMEKTMMFMILLLIIAVA
AFNLVSSLVMVVNDKQAEIAILRTIGATPSTILWVFIVQGMMVGLVGTILGLLGGLVLANNATEIVNALQSFFQVKVLSS
SIYFVDYLPSKIMFRDLWQVCAMALLMSFAATIYPAWRASKTVIAEALHYE
>Mature_450_residues
SDDELLISSLKSLGFNLGLFYKYCTILTLIQLNTIMYKPLALFIGLRYTRSRKKNHFVSFISLSSMLGIGMGVMVLITVL
SVMNGFDQEIHRRFFGMAPEITITGPDERLSDWPEVVKKVETIPGIKAIAPYVGSQGLLTHEGQVLPIVLTGILPEKEQS
VTHLNKKLLAGNMSNLKHFGIILGKGLADSLGVMIGDKVTIMIPQATVTPAGMIPRFKRFTVVGVFSAGTGFNFDTKLAF
INIEDAQKLMQMDKNDVSGIKMKINNVYKAPELSYELSDLLGEGYQVGNWTQQFGAFFEAVKMEKTMMFMILLLIIAVAA
FNLVSSLVMVVNDKQAEIAILRTIGATPSTILWVFIVQGMMVGLVGTILGLLGGLVLANNATEIVNALQSFFQVKVLSSS
IYFVDYLPSKIMFRDLWQVCAMALLMSFAATIYPAWRASKTVIAEALHYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=36.231884057971, Blast_Score=248, Evalue=6e-67,
Organism=Escherichia coli, GI1787360, Length=423, Percent_Identity=36.8794326241135, Blast_Score=229, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 49760; Mature: 49629

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDELLISSLKSLGFNLGLFYKYCTILTLIQLNTIMYKPLALFIGLRYTRSRKKNHFVS
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
FISLSSMLGIGMGVMVLITVLSVMNGFDQEIHRRFFGMAPEITITGPDERLSDWPEVVKK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
VETIPGIKAIAPYVGSQGLLTHEGQVLPIVLTGILPEKEQSVTHLNKKLLAGNMSNLKHF
HHHCCCHHHHHHHCCCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHH
GIILGKGLADSLGVMIGDKVTIMIPQATVTPAGMIPRFKRFTVVGVFSAGTGFNFDTKLA
HHHHCCCHHHHHCCEECCEEEEEECCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCEEE
FINIEDAQKLMQMDKNDVSGIKMKINNVYKAPELSYELSDLLGEGYQVGNWTQQFGAFFE
EEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
AVKMEKTMMFMILLLIIAVAAFNLVSSLVMVVNDKQAEIAILRTIGATPSTILWVFIVQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHH
MMVGLVGTILGLLGGLVLANNATEIVNALQSFFQVKVLSSSIYFVDYLPSKIMFRDLWQV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
CAMALLMSFAATIYPAWRASKTVIAEALHYE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
>Mature Secondary Structure 
SDDELLISSLKSLGFNLGLFYKYCTILTLIQLNTIMYKPLALFIGLRYTRSRKKNHFVS
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
FISLSSMLGIGMGVMVLITVLSVMNGFDQEIHRRFFGMAPEITITGPDERLSDWPEVVKK
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHH
VETIPGIKAIAPYVGSQGLLTHEGQVLPIVLTGILPEKEQSVTHLNKKLLAGNMSNLKHF
HHHCCCHHHHHHHCCCCCCEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHH
GIILGKGLADSLGVMIGDKVTIMIPQATVTPAGMIPRFKRFTVVGVFSAGTGFNFDTKLA
HHHHCCCHHHHHCCEECCEEEEEECCCCCCCCCCCCCHHHEEEEEEEECCCCCCCCCEEE
FINIEDAQKLMQMDKNDVSGIKMKINNVYKAPELSYELSDLLGEGYQVGNWTQQFGAFFE
EEEHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHH
AVKMEKTMMFMILLLIIAVAAFNLVSSLVMVVNDKQAEIAILRTIGATPSTILWVFIVQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCCCHHHHHHHHHHHH
MMVGLVGTILGLLGGLVLANNATEIVNALQSFFQVKVLSSSIYFVDYLPSKIMFRDLWQV
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
CAMALLMSFAATIYPAWRASKTVIAEALHYE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]