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The map label for this gene is mdh [H]

Identifier: 52842463

GI number: 52842463

Start: 2552202

End: 2553362

Strand: Reverse

Name: mdh [H]

Synonym: lpg2250

Alternate gene names: 52842463

Gene position: 2553362-2552202 (Counterclockwise)

Preceding gene: 52842464

Following gene: 52842462

Centisome position: 75.15

GC content: 44.1

Gene sequence:

>1161_bases
ATGAAAAACCAATCATTAATTGTCAATTGGAATTACCCGACACGAATCCTGGTTGGGGCTGGGCGAATCAATGAACTAGC
GAAAGTATGTCGTGAGTTAGGCATGAATGCTCCTCTGTTAGTCACAGACCCGGGATTGGCTTCGTCGTTAATGGTGAGTA
AAGTCATACAACAGGCTCAGGCATCCGGTTTGCGAACGGGGTTATTTTGCCAAATTAAAACAAATCCTACCGGTGACAAT
GTGATGAATGGAGTCTATGCTTTTAAAGCTGGCCAGCATGATGGCGTGATTGCTTTCGGAGGTGGCTCGGCTTTGGATGC
CGGCAAAGCCATCGCTTTAATGGTTGGCCAGGATCGACCTTTATGGGATTTTGAGGACGTGGGTGATAACTGGACTCGGG
TGAATGTTTCAGCCATGGCCCCAGTTCTTGCCATTCCAACAACAGCAGGAACTGGTTCAGAGGTCGGGCGAGCTTCTGTA
ATTACCGATGCTGAAAAGCAGGTTAAAAAAATCATTTTTCATCCTAAAATGTTGCCTGCTATGGTTATTCTGGATCCAGT
GTTAACAGTCGGTCTTCCCAAATCACTTACTGCAGCTACAGGTATGGATGCTCTTTCCCATTGTCTTGAAGCTTATTGTT
CCAATTATTATCATCCTATGGCAGAAGGTATTGCGTTGGAAGGAATAAGATTAATCAAGGAGAACTTAATTCAAGCTTAC
AAGGATGGTAGTGACCTGGAGGCAAGAACCCATATGCTGGTTGCTTCAGCAATGGGGGCTACCGCCTTTCAGCGTGGTCT
TGGAGCGATGCATGCCTTGGCTCATCCATTAGGTGCAATTTATGATGTCCATCACGGGCGGCTTAATGCGGTTTTGATGC
CCTATGTTTTATTGGCTAATCGTAGTGAAATTGAAAACAAGATAGAGCACCTGGCAAATTATTTGTCAATAGCAAATGGA
TTTGATGGTTTTTTGGATTGGATAGAGCAGATGAGATTAGAGTTAGGAATCGAAAATACATTAAGTCAGTTAGGTATTGA
TCATTCGCAGATAGACAGACTGGCAAAAATGGCCACCGAGGATGCGGCAGCAGCTTCCAATCCTGTTCTTTTTACATTAG
AGCAATACAAAGAACTATTGAGCAAAGCCATTGGTGAGTAA

Upstream 100 bases:

>100_bases
AAAACTCAAAATATAATTATAAAAAAGACCTAATCTTTCCTGCGGAAAGATACTTGCTATCAGTTACAATGGTCTTTTTC
GAATCAAAGGAAGATCACAC

Downstream 100 bases:

>100_bases
TCGTTGTAAAGGAAAAGGTGCAGAAACGGGTTGTTTGCCAGGTATAAATCAGATGGAAAGGACTTGTATATTGAAATTAA
GTCTAATCCAGACAATAAAA

Product: alcohol dehydrogenase, iron containing

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPVLTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIEHLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE

Sequences:

>Translated_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPVLTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIEHLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE
>Mature_386_residues
MKNQSLIVNWNYPTRILVGAGRINELAKVCRELGMNAPLLVTDPGLASSLMVSKVIQQAQASGLRTGLFCQIKTNPTGDN
VMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRPLWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASV
ITDAEKQVKKIIFHPKMLPAMVILDPVLTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLANRSEIENKIEHLANYLSIANG
FDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATEDAAAASNPVLFTLEQYKELLSKAIGE

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=308, Percent_Identity=26.6233766233766, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI48994951, Length=371, Percent_Identity=33.1536388140162, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87082107, Length=384, Percent_Identity=32.8125, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=31.4666666666667, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787493, Length=383, Percent_Identity=28.9817232375979, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1789386, Length=369, Percent_Identity=26.5582655826558, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=284, Percent_Identity=27.8169014084507, Blast_Score=110, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321181, Length=387, Percent_Identity=35.1421188630491, Blast_Score=226, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24657991, Length=384, Percent_Identity=23.1770833333333, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 41535; Mature: 41535

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKVCRELGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCCHHHHCHHEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
MVILDPVLTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIEHLANYLSIANGFDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTLEQYKELLSKAIGE
HHHCCCCCEEEEHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNQSLIVNWNYPTRILVGAGRINELAKVCRELGMNAPLLVTDPGLASSLMVSKVIQQAQ
CCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
ASGLRTGLFCQIKTNPTGDNVMNGVYAFKAGQHDGVIAFGGGSALDAGKAIALMVGQDRP
HCCCCCCEEEEEECCCCCCHHHHCHHEEECCCCCCEEEECCCCCCCCCCEEEEEECCCCC
LWDFEDVGDNWTRVNVSAMAPVLAIPTTAGTGSEVGRASVITDAEKQVKKIIFHPKMLPA
CCCHHHCCCCCEEEEHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHH
MVILDPVLTVGLPKSLTAATGMDALSHCLEAYCSNYYHPMAEGIALEGIRLIKENLIQAY
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHH
KDGSDLEARTHMLVASAMGATAFQRGLGAMHALAHPLGAIYDVHHGRLNAVLMPYVLLAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
RSEIENKIEHLANYLSIANGFDGFLDWIEQMRLELGIENTLSQLGIDHSQIDRLAKMATE
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHHH
DAAAASNPVLFTLEQYKELLSKAIGE
HHHCCCCCEEEEHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]