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The map label for this gene is upp

Identifier: 52842456

GI number: 52842456

Start: 2541432

End: 2542076

Strand: Direct

Name: upp

Synonym: lpg2243

Alternate gene names: 52842456

Gene position: 2541432-2542076 (Clockwise)

Preceding gene: 52842455

Following gene: 52842457

Centisome position: 74.8

GC content: 42.02

Gene sequence:

>645_bases
ATGGACTTCAATCAAGTTAAGGTTATAAATCATCCTCTCATTCAGCACAAACTCACCATAATGAGAAAAAAAGAAACCAG
CACAGTAAAATTTCGGACACTCATGCACGAAGTCAGTATGCTATTAGCCTATGAAGTCACTCGGGATTTGGAAATAGAGT
ACGAAGAAATAGAAACTCCTTTGGCCACTATGCAATCACCTGTTTTGAAAGGAAAAAAACTTGTTTTTGTCTCGATATTA
CGCGCGGGTAATGGTCTACTGGACGGCATGTTACAATTAGTTCCTACTGCCCGAATTGGTCATATAGGTCTCTATCGAGA
TCCCAAAACGCTGGAAGCAGTCGAATACTACTTCAAGCTACCTGAACACACACAAGACAGAGATGTTATTGTTGTTGACC
CCATGCTGGCGACAGGAAATTCAGCCATTGCCGCGGTTAAAGAGGTCAAGGCATTACATCCCAAGTCAATTAAATTTCTT
TGTCTACTGGCCTCTCCTGAAGGAATTTCCAATTTTCATGGAGAACATCCTGATGTCCCAATATTCACCGCAGCCATAGA
TGAGCAGCTGAATGATCATGGATACATTGTTCCTGGTTTAGGAGACGCAGGAGACAGGCTATATGGCACAAAACTGGCTC
ATTAA

Upstream 100 bases:

>100_bases
TTGGGAGGCGGGACGACAGATTGCACAAAAGAAACGAATTAATGGAACACCCCCAATAGAAATTATCAGTGATGGCACGA
TATTTTAATAAGGAATAATA

Downstream 100 bases:

>100_bases
TGCTGAATTATCCTTATTTCAGGGATACCTAATCAGCCAATAGTACGTTTAAATAATAATTAAGATTGTCTTGCCCTTTC
AGTAATGACTGCTTTCACTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLASPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH

Sequences:

>Translated_214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLASPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
>Mature_214_residues
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETPLATMQSPVLKGKKLVFVSIL
RAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKLPEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFL
CLLASPEGISNFHGEHPDVPIFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.1881188118812, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.1881188118812, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI21450816, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=50.7389162561576, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17539894, Length=205, Percent_Identity=26.3414634146341, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539892, Length=205, Percent_Identity=26.3414634146341, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=122, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=29.064039408867, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=29.064039408867, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=29.064039408867, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=29.064039408867, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23893; Mature: 23893

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETP
CCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC
LATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKL
HHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCC
PEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLASPEGISNFHGEHPDVP
CCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHCCCCCCCCC
IFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
EEEHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFNQVKVINHPLIQHKLTIMRKKETSTVKFRTLMHEVSMLLAYEVTRDLEIEYEEIETP
CCCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHCCC
LATMQSPVLKGKKLVFVSILRAGNGLLDGMLQLVPTARIGHIGLYRDPKTLEAVEYYFKL
HHHHHHHHHCCCCEEEEEHHHHCCHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHCC
PEHTQDRDVIVVDPMLATGNSAIAAVKEVKALHPKSIKFLCLLASPEGISNFHGEHPDVP
CCCCCCCCEEEECCEEECCCHHHHHHHHHHHCCCCCEEEEEEEECCCCCHHCCCCCCCCC
IFTAAIDEQLNDHGYIVPGLGDAGDRLYGTKLAH
EEEHHHHHHHCCCCEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA