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The map label for this gene is bcr [H]

Identifier: 52842447

GI number: 52842447

Start: 2525683

End: 2527050

Strand: Reverse

Name: bcr [H]

Synonym: lpg2234

Alternate gene names: 52842447

Gene position: 2527050-2525683 (Counterclockwise)

Preceding gene: 52842450

Following gene: 52842446

Centisome position: 74.37

GC content: 37.94

Gene sequence:

>1368_bases
TTGAACAGTGATAGACGCTTTGCAATAGGTATTTTCTATTTTGCAGACGTTGAGGCCAATGCCTTATTTTCTAATACTTT
TGTTTTGCTTGTAAATAATGATATTGTTATCAGCCTTGTTAGAAATCATTCTAAAGGATATTTGATGCATCAGGAACATC
CAGGCCAAACCGATACCCCAAAAATAGATCCTTGGTTAATATTTGTCATATTAATGTTGATGGCTTTGATGCAAACAACA
ACCGATCAATACATTCCTTCTCTTCCAGCGATTACCACAGCATTGAACAGCACTGAGGCGTCTATTCAGTTAACCATTTC
TATGTTTATGTTGGGTTTAAGCCTATCTCATATCTTTTATGGCCCCTTGTCAGATAAAATAGGACGCAAACCTCCGTTAA
TGTTCGGTGTTGGGCTAAGTATATTAGGTAGTTTGGTTTGTTTTGTTGCGCCCAATGTCAGTGTGTTAATCTTGGGTCGA
TTTCTTCAGGGGTTTGGAATTGGGTGTTGCAATTCAGTGGGGCGATCTTTAGTGAGAGATTTATTCACCGATCGTTTGCT
GGCTAAAATTGGTTCTTATGTCGGTGTTGTCAGTATTTTTATTATGGCAGCCTCACCCACTTTAGGAGGATTTATTCAGG
AGATGGCTGGGTGGAAAGCCAATTTTATGTTCTTATTTGTTTTTGGAATCCTTGTTTGGCTTTTAGCATTTTGTATTCTT
CCTGAAACGAATAAACACTTAAATCCTGAAGCTACAAAAATCAAAGTGATGGCGAAGAATTATTTCACCTTATTACGTAG
CAAGATCTTTGTGGGATATACAATGTGTGCTTGCTTTGCTTTTGCGGGAATGGTTTCTTATCTTACGATTGCGCCATTTT
TATTTCAAAATACCATGGGATTGAGTCCCTTGGAATTTGGACGTTTAACTTTTTTTATTGCGGGCGCCATCTGTTTTAGC
GGGATTGTCAACAGTCAGTTGGTCATGCGTAAAGGAATATCCTTTATGGTTTGTACCGGTGTTCTTTTTATGATTGTCGG
TGGTTTAAGCCTGTTATTAATTACGATACTGGGTTGGTCACAAATCTATTTTATTATGATTTCAATGACATTATTTAGTG
CTGGCGCCGGATTTACATTTATTAATGCCTTTGCCGGTGCGTTTCATCCTTTTCCGCAAATGGCTGGAACGGTTGGGGCT
TTATATGCCAGCATGCAGGATTTAAGTGCAGCATTGACCAGTGGTTTTATTGCGGGAATTAAGGGGTATGGTCAATATTC
TTTAGCTATAATATTACTGATTTTAGGTTTAAGTTCTTTAGTGGCATGGTATTATCTTGGATTGCAAGATGACGCTATTT
CAAATTAA

Upstream 100 bases:

>100_bases
CACCGGATTTTTTATAATAGGCTACCCAAGTTTCAATTCCTATGAGGATCAAAAAAAGAGGTGAGGCAAAAACCATTAAA
TTTATATCCATAAATATCCT

Downstream 100 bases:

>100_bases
GGGGTATTAATGAAAATTACCGATGAAGAATTGAAAAAAATTATCAGCAAATTATCTGGCTCTAAAGCCGATGAAATTCA
AGATGATACGGCCCTAATAG

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNSDRRFAIGIFYFADVEANALFSNTFVLLVNNDIVISLVRNHSKGYLMHQEHPGQTDTPKIDPWLIFVILMLMALMQTT
TDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIGRKPPLMFGVGLSILGSLVCFVAPNVSVLILGR
FLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVFGILVWLLAFCIL
PETNKHLNPEATKIKVMAKNYFTLLRSKIFVGYTMCACFAFAGMVSYLTIAPFLFQNTMGLSPLEFGRLTFFIAGAICFS
GIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITILGWSQIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTVGA
LYASMQDLSAALTSGFIAGIKGYGQYSLAIILLILGLSSLVAWYYLGLQDDAISN

Sequences:

>Translated_455_residues
MNSDRRFAIGIFYFADVEANALFSNTFVLLVNNDIVISLVRNHSKGYLMHQEHPGQTDTPKIDPWLIFVILMLMALMQTT
TDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIGRKPPLMFGVGLSILGSLVCFVAPNVSVLILGR
FLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVFGILVWLLAFCIL
PETNKHLNPEATKIKVMAKNYFTLLRSKIFVGYTMCACFAFAGMVSYLTIAPFLFQNTMGLSPLEFGRLTFFIAGAICFS
GIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITILGWSQIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTVGA
LYASMQDLSAALTSGFIAGIKGYGQYSLAIILLILGLSSLVAWYYLGLQDDAISN
>Mature_455_residues
MNSDRRFAIGIFYFADVEANALFSNTFVLLVNNDIVISLVRNHSKGYLMHQEHPGQTDTPKIDPWLIFVILMLMALMQTT
TDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFYGPLSDKIGRKPPLMFGVGLSILGSLVCFVAPNVSVLILGR
FLQGFGIGCCNSVGRSLVRDLFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVFGILVWLLAFCIL
PETNKHLNPEATKIKVMAKNYFTLLRSKIFVGYTMCACFAFAGMVSYLTIAPFLFQNTMGLSPLEFGRLTFFIAGAICFS
GIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITILGWSQIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTVGA
LYASMQDLSAALTSGFIAGIKGYGQYSLAIILLILGLSSLVAWYYLGLQDDAISN

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=347, Percent_Identity=27.3775216138329, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790146, Length=354, Percent_Identity=27.683615819209, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082312, Length=357, Percent_Identity=27.4509803921569, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI48994889, Length=336, Percent_Identity=27.0833333333333, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1787065, Length=299, Percent_Identity=20.7357859531773, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081983, Length=180, Percent_Identity=28.8888888888889, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=191, Percent_Identity=27.7486910994764, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49619; Mature: 49619

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSDRRFAIGIFYFADVEANALFSNTFVLLVNNDIVISLVRNHSKGYLMHQEHPGQTDTP
CCCCCEEEEEEEEEECCCCCEEEECEEEEEECCCEEEEEECCCCCCCEEECCCCCCCCCC
KIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GPLSDKIGRKPPLMFGVGLSILGSLVCFVAPNVSVLILGRFLQGFGIGCCNSVGRSLVRD
CCCHHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVFGILVWLLAFCIL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PETNKHLNPEATKIKVMAKNYFTLLRSKIFVGYTMCACFAFAGMVSYLTIAPFLFQNTMG
CCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITILGWS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTVGALYASMQDLSAALTSGFIAGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGYGQYSLAIILLILGLSSLVAWYYLGLQDDAISN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC
>Mature Secondary Structure
MNSDRRFAIGIFYFADVEANALFSNTFVLLVNNDIVISLVRNHSKGYLMHQEHPGQTDTP
CCCCCEEEEEEEEEECCCCCEEEECEEEEEECCCEEEEEECCCCCCCEEECCCCCCCCCC
KIDPWLIFVILMLMALMQTTTDQYIPSLPAITTALNSTEASIQLTISMFMLGLSLSHIFY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
GPLSDKIGRKPPLMFGVGLSILGSLVCFVAPNVSVLILGRFLQGFGIGCCNSVGRSLVRD
CCCHHHCCCCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LFTDRLLAKIGSYVGVVSIFIMAASPTLGGFIQEMAGWKANFMFLFVFGILVWLLAFCIL
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PETNKHLNPEATKIKVMAKNYFTLLRSKIFVGYTMCACFAFAGMVSYLTIAPFLFQNTMG
CCCCCCCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LSPLEFGRLTFFIAGAICFSGIVNSQLVMRKGISFMVCTGVLFMIVGGLSLLLITILGWS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIYFIMISMTLFSAGAGFTFINAFAGAFHPFPQMAGTVGALYASMQDLSAALTSGFIAGI
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGYGQYSLAIILLILGLSSLVAWYYLGLQDDAISN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]