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The map label for this gene is qor [C]

Identifier: 52842421

GI number: 52842421

Start: 2492063

End: 2493076

Strand: Reverse

Name: qor [C]

Synonym: lpg2208

Alternate gene names: 52842421

Gene position: 2493076-2492063 (Counterclockwise)

Preceding gene: 52842423

Following gene: 52842420

Centisome position: 73.37

GC content: 40.73

Gene sequence:

>1014_bases
ATGAAAGCAATAGGTTACTACCACTCTTTACCCATTACAGATAATAAAGCATTGATGGACCTGGATGTTTCTGTGCCCAA
AGCAACTGGCCACGATATTTTAGTTGAAATCAAAGCTGTTGCAGTGAATCCCGTAGATACCAAGGTGCGTCGTAATGTTC
AACCAGAACCTCATCAGCCCAAAATATTAGGCTGGGATGCTTCCGGGGTAGTTACTGAAATTGGATCGGAGGTGACTATG
TTTAAACCAGGTGATGAAGTGTGGTATGCCGGTGATTTAACCAGACCAGGGTCTAATTGTGAATTTCACCTTGTTGACGA
ACGCATCGCAGCCAAAAAACCAAAATCGTTAAGTTTTCAAGAGGCTGCTGCATTACCTTTAACCAGTTTAACAGCTTGGG
AGCTTTTATTTGATAGATTGCAATTATCAGCAGAAGATAAAGGTATTCTATTAATTACTGGAGCGGCTGGGGGGGTTGGT
TCTATTTTGGTACAACTGGCAAGGCAACTTACCCAGTTAACTATCATCGGAACAGGAGCCCGCCCTGAATCAATTCAGTG
GATCCTGGATAATGGGGCTCACCATGTCATTGATCACACTAAAGACATGAAGGCTCAATTGCAGAATTTACATTATTCTG
AAGTGGATTATGTGATCAGTTTGACCCATACCGATCAACATGCCAAATCGCTAGTTGAGGTCCTGAAACCTCAAGGAAAA
TTTGCTTTGATAGATGACCCTCAGAATTTGGATATTAAATTATTTAAACTAAAAAGCATTTCTATTCACTGGGAAATGAT
GTACACCCGCTCTATGTTTAAAACAGCAGATATGATAAAGCAACATGATATTTTAACAGAGGTTGCCAGATTGGTGGATG
CCGGTAAAATCAAGACAACTATTGCCGAATGTCTGGGATTGATCAATGCTGACAATTTGAGAAGAGCACATGCTTTATTG
GAAAGTGGCACTTCCAGAGGCAAGATCGTTTTGAATGGATTCAAGTCAATTTAG

Upstream 100 bases:

>100_bases
TTTTGTAAGTCCCATTCATATGAGAAATGCCTTGTGCTGTTGTTTATAAAATTTTCTAAACCTATAATGAAACTCCAGTA
TTTTTAAAGGAATAATTTCA

Downstream 100 bases:

>100_bases
TTATTCTCGAAACAGCGACGATGCCTGGAATGAAACAGATAGAGTCACTTGATTTTTAAATGATTCTCTAAATAGCCTAC
GTGCCTCAGCTTGTCTGAGG

Product: zinc binding dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAIGYYHSLPITDNKALMDLDVSVPKATGHDILVEIKAVAVNPVDTKVRRNVQPEPHQPKILGWDASGVVTEIGSEVTM
FKPGDEVWYAGDLTRPGSNCEFHLVDERIAAKKPKSLSFQEAAALPLTSLTAWELLFDRLQLSAEDKGILLITGAAGGVG
SILVQLARQLTQLTIIGTGARPESIQWILDNGAHHVIDHTKDMKAQLQNLHYSEVDYVISLTHTDQHAKSLVEVLKPQGK
FALIDDPQNLDIKLFKLKSISIHWEMMYTRSMFKTADMIKQHDILTEVARLVDAGKIKTTIAECLGLINADNLRRAHALL
ESGTSRGKIVLNGFKSI

Sequences:

>Translated_337_residues
MKAIGYYHSLPITDNKALMDLDVSVPKATGHDILVEIKAVAVNPVDTKVRRNVQPEPHQPKILGWDASGVVTEIGSEVTM
FKPGDEVWYAGDLTRPGSNCEFHLVDERIAAKKPKSLSFQEAAALPLTSLTAWELLFDRLQLSAEDKGILLITGAAGGVG
SILVQLARQLTQLTIIGTGARPESIQWILDNGAHHVIDHTKDMKAQLQNLHYSEVDYVISLTHTDQHAKSLVEVLKPQGK
FALIDDPQNLDIKLFKLKSISIHWEMMYTRSMFKTADMIKQHDILTEVARLVDAGKIKTTIAECLGLINADNLRRAHALL
ESGTSRGKIVLNGFKSI
>Mature_337_residues
MKAIGYYHSLPITDNKALMDLDVSVPKATGHDILVEIKAVAVNPVDTKVRRNVQPEPHQPKILGWDASGVVTEIGSEVTM
FKPGDEVWYAGDLTRPGSNCEFHLVDERIAAKKPKSLSFQEAAALPLTSLTAWELLFDRLQLSAEDKGILLITGAAGGVG
SILVQLARQLTQLTIIGTGARPESIQWILDNGAHHVIDHTKDMKAQLQNLHYSEVDYVISLTHTDQHAKSLVEVLKPQGK
FALIDDPQNLDIKLFKLKSISIHWEMMYTRSMFKTADMIKQHDILTEVARLVDAGKIKTTIAECLGLINADNLRRAHALL
ESGTSRGKIVLNGFKSI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=336, Percent_Identity=29.1666666666667, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194239674, Length=179, Percent_Identity=32.9608938547486, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI13236495, Length=179, Percent_Identity=32.9608938547486, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI194239676, Length=179, Percent_Identity=32.9608938547486, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI24308257, Length=298, Percent_Identity=24.496644295302, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI18379349, Length=210, Percent_Identity=31.9047619047619, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1790485, Length=307, Percent_Identity=29.9674267100977, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17507255, Length=230, Percent_Identity=30, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71987554, Length=353, Percent_Identity=25.4957507082153, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319520, Length=324, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319945, Length=238, Percent_Identity=27.3109243697479, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323493, Length=238, Percent_Identity=26.4705882352941, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 37192; Mature: 37192

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIGYYHSLPITDNKALMDLDVSVPKATGHDILVEIKAVAVNPVDTKVRRNVQPEPHQP
CCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCC
KILGWDASGVVTEIGSEVTMFKPGDEVWYAGDLTRPGSNCEFHLVDERIAAKKPKSLSFQ
CEEEECCCCHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCCHH
EAAALPLTSLTAWELLFDRLQLSAEDKGILLITGAAGGVGSILVQLARQLTQLTIIGTGA
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECCC
RPESIQWILDNGAHHVIDHTKDMKAQLQNLHYSEVDYVISLTHTDQHAKSLVEVLKPQGK
CCCCEEEEECCCCCEECCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
FALIDDPQNLDIKLFKLKSISIHWEMMYTRSMFKTADMIKQHDILTEVARLVDAGKIKTT
EEEEECCCCCCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IAECLGLINADNLRRAHALLESGTSRGKIVLNGFKSI
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCC
>Mature Secondary Structure
MKAIGYYHSLPITDNKALMDLDVSVPKATGHDILVEIKAVAVNPVDTKVRRNVQPEPHQP
CCCCCEEEECCCCCCCEEEEEECCCCCCCCCEEEEEEEEEEECCCCHHHHCCCCCCCCCC
KILGWDASGVVTEIGSEVTMFKPGDEVWYAGDLTRPGSNCEFHLVDERIAAKKPKSLSFQ
CEEEECCCCHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCCHH
EAAALPLTSLTAWELLFDRLQLSAEDKGILLITGAAGGVGSILVQLARQLTQLTIIGTGA
HHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEECCC
RPESIQWILDNGAHHVIDHTKDMKAQLQNLHYSEVDYVISLTHTDQHAKSLVEVLKPQGK
CCCCEEEEECCCCCEECCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHCCCCC
FALIDDPQNLDIKLFKLKSISIHWEMMYTRSMFKTADMIKQHDILTEVARLVDAGKIKTT
EEEEECCCCCCEEEEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
IAECLGLINADNLRRAHALLESGTSRGKIVLNGFKSI
HHHHHHHCCCCHHHHHHHHHHCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA