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The map label for this gene is yegE [H]

Identifier: 52842346

GI number: 52842346

Start: 2375275

End: 2376813

Strand: Reverse

Name: yegE [H]

Synonym: lpg2132

Alternate gene names: 52842346

Gene position: 2376813-2375275 (Counterclockwise)

Preceding gene: 52842348

Following gene: 52842345

Centisome position: 69.95

GC content: 32.49

Gene sequence:

>1539_bases
ATGCAAAAGGCCAATGCAAAGATTCAAAATATAAATGAAATAATGTTTTCAGATCGCGTAATGTTACTAAATAAAAATTT
ATTAGTGAGCATTCCTGCAAATTTTTTATGCGCATTAATTATTTATATTGATTTCAATAAAACAACAACAGATCAAGAAA
TGCTCTCAGTATGGTTTATGGTTGGAGTAACAGTATTTGTTCTCCATGGAGGTTTATTTTTATTTAATTATTATCGTTCC
TTGCCATCCAAATACCTTTTAAAATGGTTAATAAGCGTCACTGCGATTTATGGGGCTCTATGGGGAATAGCAGGTTCTGT
TCTTATTCCTCAAAATGATCTGTTAAATCAAATGATTGTCATAATTATAATTATTGGAATCGCATCAGGTGGATTACATA
TTCTTCAGCCCAGTTTTTTAGCAAGTCTATTATTTTTTACATTAACCCTTATTCCTCTATGTGTCTGGTTTTTTCAGCAA
AGTACACTTAACTATTGGTTCCTTGGAACTGCATTGCTGATTTACTTTTGTTTTTTATTAATTATATCCTGGATGGGATA
TGGACTTCTTAATAAGAATTTTAAATTACGTTATGAGAATTTGGATTTAATTAATAAATTGTATGCAATTAACGCTAATT
TGGAGGAAAGTGAGTTACGTTTCCGTTCCGCATTTAATTCTGCTGCTATTGGTATGGCTATAGTTTCTTTGGAGGGGATG
TGGTTAAAGGTTAATCAATCGCTTTGTCAGATTGTAGGATACTCAGAAGAAGAATTATTGGAAACTAATTTTCAATCGAT
CACTCATCCAGAGGATTTAGAGCTCGATTTGGGTTATGTGAGGCAATTATTAGAGGGGGATATAAGATTCTATCATATGG
AAAAACGCTATATTCACAAAAATGGTAGTGTCATTTGGATTTTACTCAGTGCTTCTTTAATTCGAGATCTCGACAATAAA
CCACTCTATTTTATCTCGCAAATTCAAAACATTGATGCTCAAAAACGAGCAGAGCAAGAACTTCAACACATCGCATATCA
TGACACTTTAACTGGTTTGGGAAATAGAAAGCTATTAGAGTTATCATTTGACCAGGCATTAGCTCATGCGAAACGTCACC
AAACGCAAATTGCTATTATGTTTATGGATTTGGATTATTTTAAAAATGTGAATGACAAATTGGGTCATGATATTGGGGAT
CTTTTATTAGTTGAGATTGGGAAAAGATTACAGACGATTTTAAGGTCTACTGATCTAATTGTCAGGCATGGTGGTGATGA
ATTCATTATCGCGCTTACTGAATTATCCAATGTAAATCAAGTTATAGAAATAGCAAATAAAATTCTAATTGCTGTAAGCA
AGCCTATCACAATCAAACGTTATGGTATTTCAATTACAGGCAGTATTGGTATAAGTATCTATCCATATGACGGCGATGAT
TCAGACACATTAATTAGAAAAGCTGATGAAGCATTATATAGGGTGAAAATAGGGGGAAAAAATAATTTTCAATTGTTCAA
TACCGTGTTACATAAGTAA

Upstream 100 bases:

>100_bases
TAACAATTAAGTATTTTTGTACTATATTAATACAATATATTAATACAATAGGGTTCAAATTGAGGTTTTGAATTTGTCAC
TTTATCTCAGTGAGTGCTGA

Downstream 100 bases:

>100_bases
GACTCTCTTGATCATACTCTGGCATTGACTTATAAACCTGGTAATGGGTGGGGGTTTATGGATATTAATCAATACCCCTC
TAAAGTTTTTAAAACCGAAG

Product: sensory box/GGDEF family protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MQKANAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFMVGVTVFVLHGGLFLFNYYRS
LPSKYLLKWLISVTAIYGALWGIAGSVLIPQNDLLNQMIVIIIIIGIASGGLHILQPSFLASLLFFTLTLIPLCVWFFQQ
STLNYWFLGTALLIYFCFLLIISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
WLKVNQSLCQIVGYSEEELLETNFQSITHPEDLELDLGYVRQLLEGDIRFYHMEKRYIHKNGSVIWILLSASLIRDLDNK
PLYFISQIQNIDAQKRAEQELQHIAYHDTLTGLGNRKLLELSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGD
LLLVEIGKRLQTILRSTDLIVRHGGDEFIIALTELSNVNQVIEIANKILIAVSKPITIKRYGISITGSIGISIYPYDGDD
SDTLIRKADEALYRVKIGGKNNFQLFNTVLHK

Sequences:

>Translated_512_residues
MQKANAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFMVGVTVFVLHGGLFLFNYYRS
LPSKYLLKWLISVTAIYGALWGIAGSVLIPQNDLLNQMIVIIIIIGIASGGLHILQPSFLASLLFFTLTLIPLCVWFFQQ
STLNYWFLGTALLIYFCFLLIISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
WLKVNQSLCQIVGYSEEELLETNFQSITHPEDLELDLGYVRQLLEGDIRFYHMEKRYIHKNGSVIWILLSASLIRDLDNK
PLYFISQIQNIDAQKRAEQELQHIAYHDTLTGLGNRKLLELSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGD
LLLVEIGKRLQTILRSTDLIVRHGGDEFIIALTELSNVNQVIEIANKILIAVSKPITIKRYGISITGSIGISIYPYDGDD
SDTLIRKADEALYRVKIGGKNNFQLFNTVLHK
>Mature_512_residues
MQKANAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFMVGVTVFVLHGGLFLFNYYRS
LPSKYLLKWLISVTAIYGALWGIAGSVLIPQNDLLNQMIVIIIIIGIASGGLHILQPSFLASLLFFTLTLIPLCVWFFQQ
STLNYWFLGTALLIYFCFLLIISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
WLKVNQSLCQIVGYSEEELLETNFQSITHPEDLELDLGYVRQLLEGDIRFYHMEKRYIHKNGSVIWILLSASLIRDLDNK
PLYFISQIQNIDAQKRAEQELQHIAYHDTLTGLGNRKLLELSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGD
LLLVEIGKRLQTILRSTDLIVRHGGDEFIIALTELSNVNQVIEIANKILIAVSKPITIKRYGISITGSIGISIYPYDGDD
SDTLIRKADEALYRVKIGGKNNFQLFNTVLHK

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=148, Percent_Identity=49.3243243243243, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787541, Length=191, Percent_Identity=31.9371727748691, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI145693134, Length=205, Percent_Identity=36.0975609756098, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI87081881, Length=305, Percent_Identity=28.1967213114754, Blast_Score=108, Evalue=9e-25,
Organism=Escherichia coli, GI1786584, Length=195, Percent_Identity=29.2307692307692, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87082007, Length=170, Percent_Identity=35.2941176470588, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787802, Length=144, Percent_Identity=34.7222222222222, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081977, Length=169, Percent_Identity=31.9526627218935, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787816, Length=155, Percent_Identity=34.8387096774194, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=32.1212121212121, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081921, Length=180, Percent_Identity=28.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788956, Length=158, Percent_Identity=30.379746835443, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081974, Length=149, Percent_Identity=31.5436241610738, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788085, Length=169, Percent_Identity=31.3609467455621, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 58426; Mature: 58426

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKANAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFM
CCCCCCHHHHHHHHHHCCEEEEEECCEEEECCHHHHEEEEEEEECCCCCCHHHHHHHHHH
VGVTVFVLHGGLFLFNYYRSLPSKYLLKWLISVTAIYGALWGIAGSVLIPQNDLLNQMIV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHH
IIIIIGIASGGLHILQPSFLASLLFFTLTLIPLCVWFFQQSTLNYWFLGTALLIYFCFLL
HHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
HHHHHCCHHCCCCCEEEECCHHHHHHHHEECCCCCHHHHHHHHHHCCHHHHHHEEEECCE
WLKVNQSLCQIVGYSEEELLETNFQSITHPEDLELDLGYVRQLLEGDIRFYHMEKRYIHK
EEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHEEC
NGSVIWILLSASLIRDLDNKPLYFISQIQNIDAQKRAEQELQHIAYHDTLTGLGNRKLLE
CCCEEEEEEEHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGDLLLVEIGKRLQTILRSTDLI
EEHHHHHHHHHHCCCEEEEEEEECHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEE
VRHGGDEFIIALTELSNVNQVIEIANKILIAVSKPITIKRYGISITGSIGISIYPYDGDD
EEECCCEEEEEEECCCCHHHHHHHHHHHEEEECCCEEEEEECEEEEEEEEEEEEECCCCC
SDTLIRKADEALYRVKIGGKNNFQLFNTVLHK
CHHHHHHHHHCEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MQKANAKIQNINEIMFSDRVMLLNKNLLVSIPANFLCALIIYIDFNKTTTDQEMLSVWFM
CCCCCCHHHHHHHHHHCCEEEEEECCEEEECCHHHHEEEEEEEECCCCCCHHHHHHHHHH
VGVTVFVLHGGLFLFNYYRSLPSKYLLKWLISVTAIYGALWGIAGSVLIPQNDLLNQMIV
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHH
IIIIIGIASGGLHILQPSFLASLLFFTLTLIPLCVWFFQQSTLNYWFLGTALLIYFCFLL
HHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
IISWMGYGLLNKNFKLRYENLDLINKLYAINANLEESELRFRSAFNSAAIGMAIVSLEGM
HHHHHCCHHCCCCCEEEECCHHHHHHHHEECCCCCHHHHHHHHHHCCHHHHHHEEEECCE
WLKVNQSLCQIVGYSEEELLETNFQSITHPEDLELDLGYVRQLLEGDIRFYHMEKRYIHK
EEEHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEEHHHHEEC
NGSVIWILLSASLIRDLDNKPLYFISQIQNIDAQKRAEQELQHIAYHDTLTGLGNRKLLE
CCCEEEEEEEHHHHHHCCCCCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEE
LSFDQALAHAKRHQTQIAIMFMDLDYFKNVNDKLGHDIGDLLLVEIGKRLQTILRSTDLI
EEHHHHHHHHHHCCCEEEEEEEECHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCEE
VRHGGDEFIIALTELSNVNQVIEIANKILIAVSKPITIKRYGISITGSIGISIYPYDGDD
EEECCCEEEEEEECCCCHHHHHHHHHHHEEEECCCEEEEEECEEEEEEEEEEEEECCCCC
SDTLIRKADEALYRVKIGGKNNFQLFNTVLHK
CHHHHHHHHHCEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]