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The map label for this gene is msrAB [H]

Identifier: 52842325

GI number: 52842325

Start: 2357327

End: 2357848

Strand: Reverse

Name: msrAB [H]

Synonym: lpg2111

Alternate gene names: 52842325

Gene position: 2357848-2357327 (Counterclockwise)

Preceding gene: 52842329

Following gene: 52842324

Centisome position: 69.39

GC content: 37.36

Gene sequence:

>522_bases
ATGAAGAGTATTATCAAAGGTTTGTTATTTTTTTTCATGAGTGTTGCCTCTTTGACAGCCTATGCAGAACAAGCCTATAA
ACGACCTTCAGATGCTGTCATCAAACAAAAATTATCAACAATTCAATATAATGTTACTCAACAACAGGGTACAGAATCCC
CGTTTAATAATGCTTATTGGAATAATGAAGAGCAAGGTATTTATGTTGATGTTGTTACCGGTGAACCATTATTTATTTCG
CTCGATAAATATGACTCTAAGACTGGCTGGCCGAGTTTTACCAAACCGCTAGAACCTGGAAACATAATATATAAAGATGA
TAGCAGCATGTTTACTAGTCGGACTGAAGTGATTTCCAAACATGGAAAATCACATTTGGGGCATGTTTTTGGTGACGGCC
CTCCGCCCACCAATAAACGTTTTTGCATGAATTCTGCGGCGCTGGAATTTATTCCAGTCAAGGATCTGCAGAAAAGAGGT
TATGGTAAGTATTTGCCACTATTCAAAAATGCAGGAAAATAA

Upstream 100 bases:

>100_bases
CATATAACTTACGTCAAGGAAATTGACAGTTGTTCGGAATTCTGTTGTTCGGAATTCTGACTATACTTAAGAATAGAGCA
TTAATCAGTGAGAAACCACC

Downstream 100 bases:

>100_bases
CGTGAAGTAATATGCCATGTTTATGGCTCACAACAAGATTTGCCTTTGATAAACAGAGCTTAGGCAGTTGAGTGGTTTTG
CCTGGTTTTTGCAATTTATC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MKSIIKGLLFFFMSVASLTAYAEQAYKRPSDAVIKQKLSTIQYNVTQQQGTESPFNNAYWNNEEQGIYVDVVTGEPLFIS
LDKYDSKTGWPSFTKPLEPGNIIYKDDSSMFTSRTEVISKHGKSHLGHVFGDGPPPTNKRFCMNSAALEFIPVKDLQKRG
YGKYLPLFKNAGK

Sequences:

>Translated_173_residues
MKSIIKGLLFFFMSVASLTAYAEQAYKRPSDAVIKQKLSTIQYNVTQQQGTESPFNNAYWNNEEQGIYVDVVTGEPLFIS
LDKYDSKTGWPSFTKPLEPGNIIYKDDSSMFTSRTEVISKHGKSHLGHVFGDGPPPTNKRFCMNSAALEFIPVKDLQKRG
YGKYLPLFKNAGK
>Mature_173_residues
MKSIIKGLLFFFMSVASLTAYAEQAYKRPSDAVIKQKLSTIQYNVTQQQGTESPFNNAYWNNEEQGIYVDVVTGEPLFIS
LDKYDSKTGWPSFTKPLEPGNIIYKDDSSMFTSRTEVISKHGKSHLGHVFGDGPPPTNKRFCMNSAALEFIPVKDLQKRG
YGKYLPLFKNAGK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=120, Percent_Identity=46.6666666666667, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI301336162, Length=120, Percent_Identity=46.6666666666667, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI73089054, Length=120, Percent_Identity=46.6666666666667, Blast_Score=121, Evalue=3e-28,
Organism=Homo sapiens, GI37620216, Length=120, Percent_Identity=46.6666666666667, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI117606353, Length=127, Percent_Identity=45.6692913385827, Blast_Score=116, Evalue=8e-27,
Organism=Escherichia coli, GI1788077, Length=123, Percent_Identity=44.7154471544715, Blast_Score=114, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17553450, Length=110, Percent_Identity=39.0909090909091, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115532676, Length=110, Percent_Identity=39.0909090909091, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319816, Length=142, Percent_Identity=33.8028169014084, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221378664, Length=119, Percent_Identity=43.6974789915966, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24645799, Length=119, Percent_Identity=44.5378151260504, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI45553335, Length=119, Percent_Identity=44.5378151260504, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI21356369, Length=119, Percent_Identity=44.5378151260504, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221378662, Length=126, Percent_Identity=41.2698412698413, Blast_Score=116, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24645801, Length=130, Percent_Identity=40.7692307692308, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24645804, Length=130, Percent_Identity=40.7692307692308, Blast_Score=112, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19475; Mature: 19475

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIIKGLLFFFMSVASLTAYAEQAYKRPSDAVIKQKLSTIQYNVTQQQGTESPFNNAYW
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHCCCCCCCCCCCC
NNEEQGIYVDVVTGEPLFISLDKYDSKTGWPSFTKPLEPGNIIYKDDSSMFTSRTEVISK
CCCCCCEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
HGKSHLGHVFGDGPPPTNKRFCMNSAALEFIPVKDLQKRGYGKYLPLFKNAGK
HCHHHCCCCCCCCCCCCCCEEECCCCCEEEECHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSIIKGLLFFFMSVASLTAYAEQAYKRPSDAVIKQKLSTIQYNVTQQQGTESPFNNAYW
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCHHCCCCCCCCCCCC
NNEEQGIYVDVVTGEPLFISLDKYDSKTGWPSFTKPLEPGNIIYKDDSSMFTSRTEVISK
CCCCCCEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHH
HGKSHLGHVFGDGPPPTNKRFCMNSAALEFIPVKDLQKRGYGKYLPLFKNAGK
HCHHHCCCCCCCCCCCCCCEEECCCCCEEEECHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]