Click here to switch to the map view.

The map label for this gene is mvaA [H]

Identifier: 52842269

GI number: 52842269

Start: 2294267

End: 2295565

Strand: Direct

Name: mvaA [H]

Synonym: lpg2052

Alternate gene names: 52842269

Gene position: 2294267-2295565 (Clockwise)

Preceding gene: 52842268

Following gene: 52842270

Centisome position: 67.52

GC content: 40.34

Gene sequence:

>1299_bases
ATGTCCATAGCTGCTAATGCCGGTGAATTATTTCGCGGATTCTCAAAGTTATCACGTGAAGAGCGCTTTCAAAGGTTATG
CGCTTTAGGTGCCTTGACTCATGAAGACATAACATTTCTTAAACAAGGTGGTATTAAAGATTTAAACTTGGCCGACAAAT
TGATTGAAAATGTGATTGGATATTTTCAGCTTCCATTGGGTGTGGCTACTAATTTTAATATTGATGGACGTGATTATGTA
ATACCTTTGGCAGTGGAAGAAACCTCTATTATTGCTGCTCTTTCCAAATCAGCGAAATGGATTAGGCAGCATGGTGAAAT
CAATACCTGGGTTCACGGAGAATGTATTCTTGGGCAAATTCAACTGGCAAAAATAAAGGACTTTCAAAGATTCTCTGACC
TCTTTAATAAAAATCGTCAATATTTTATAGAAATAGCGAATAAAGACGTTGCCGCCAATATGGTCAAACGAGGCGGCGGT
GTTACGGATTTGCAAGTACGTCATTTAAAGAGAGACGATGGACAAGATATGGCAGTAATTCATTTGACGATGAACAGCTG
CGATGCTATGGGTGCCAATATCATCAATCAAGTACTTGAATATTTAAAACAACCCATAGAACAAATAACTGGTGAAGAAG
TCACCATGTGTATTTTATCGAACTTAAATGATCAAAAATTAACGACCGCTCAAGTCATCATTCGTAATATTGACCCCATC
CTCGGTCAAAAATTGCAAGAGGCCTCACTCTTTGCAGAAATAGATCCCTATCGCGCTGCTACCCATAATAAAGGGGTTAT
GAATGGAATTGATCCGGTTTTAATTGCTACAGGGAATGATTGGCGAGCTGTGGAAGCTGGAATACACGCCTATGCGGCAC
GTTCGGGACAATACAAAGCAATTACTCGCTGGCGGTATCAAAATGAAATACTCACAGGAGAGTTAACTGCTCCTATCATA
GTAGGTACTGTTGGAGGCGTAACCTCTTTACACCCCACGGCTAAAATGTGTTTACGAATGATGGATATCACTTCTGCCAA
TCAACTCTCCCAAGTCATCGCAGCAGTTGGACTAGTGCAAAATCTTGGCGCACTCAAAGCTTTATGCACTGACGGGATCA
TTCAAGGCCATATGAAATTGCATATTGATAATTTGCTATTAGTTGCAGGGGCTAATGAAAATGAAATGCCCGTGCTCAAA
GAAAAATTGCAAGAATGGCTTAACCTGAACAAACGAGTCAGCTTGAATAACGCTTATGACCTATTAGCTGAAATCCGACA
AGCTCCTGTTGCAGTATGA

Upstream 100 bases:

>100_bases
CCGGGCAAGTACTGACCCAAATGAATACAATTGAATATGAATTGAAAACTGCTATGTTTTGTACTGGCAGCCGAGTTCTT
GATGATTTAAAGGAGAAGGC

Downstream 100 bases:

>100_bases
AATGGCAAATTCCCGCTAAAACATTTTTACTAGGAGAATACGCTGCCATTGCGGGAGAACCAGCTATCCTATTAACGACA
AGCCCTTGCTTTACTCTTAC

Product: hydroxymethylglutaryl CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYV
IPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKIKDFQRFSDLFNKNRQYFIEIANKDVAANMVKRGGG
VTDLQVRHLKRDDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI
LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHAYAARSGQYKAITRWRYQNEILTGELTAPII
VGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLK
EKLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV

Sequences:

>Translated_432_residues
MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYV
IPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKIKDFQRFSDLFNKNRQYFIEIANKDVAANMVKRGGG
VTDLQVRHLKRDDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI
LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHAYAARSGQYKAITRWRYQNEILTGELTAPII
VGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLK
EKLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV
>Mature_431_residues
SIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIGYFQLPLGVATNFNIDGRDYVI
PLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQIQLAKIKDFQRFSDLFNKNRQYFIEIANKDVAANMVKRGGGV
TDLQVRHLKRDDGQDMAVIHLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPIL
GQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHAYAARSGQYKAITRWRYQNEILTGELTAPIIV
GTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQNLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKE
KLQEWLNLNKRVSLNNAYDLLAEIRQAPVAV

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 47734; Mature: 47603

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS01192 HMG_COA_REDUCTASE_3 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
YFQLPLGVATNFNIDGRDYVIPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQI
HHCCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCE
QLAKIKDFQRFSDLFNKNRQYFIEIANKDVAANMVKRGGGVTDLQVRHLKRDDGQDMAVI
EHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEE
HLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHHHHHHHHHHHCCHH
LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHAYAARSGQYKA
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEH
ITRWRYQNEILTGELTAPIIVGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQ
HHHHHHHCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKEKLQEWLNLNKRVSLNNAYD
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHH
LLAEIRQAPVAV
HHHHHHHCCCCC
>Mature Secondary Structure 
SIAANAGELFRGFSKLSREERFQRLCALGALTHEDITFLKQGGIKDLNLADKLIENVIG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHH
YFQLPLGVATNFNIDGRDYVIPLAVEETSIIAALSKSAKWIRQHGEINTWVHGECILGQI
HHCCCCCCEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEECCEEEECCE
QLAKIKDFQRFSDLFNKNRQYFIEIANKDVAANMVKRGGGVTDLQVRHLKRDDGQDMAVI
EHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEE
HLTMNSCDAMGANIINQVLEYLKQPIEQITGEEVTMCILSNLNDQKLTTAQVIIRNIDPI
EEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCCHHHHHHHHHHHCCHH
LGQKLQEASLFAEIDPYRAATHNKGVMNGIDPVLIATGNDWRAVEAGIHAYAARSGQYKA
HHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEH
ITRWRYQNEILTGELTAPIIVGTVGGVTSLHPTAKMCLRMMDITSANQLSQVIAAVGLVQ
HHHHHHHCCEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NLGALKALCTDGIIQGHMKLHIDNLLLVAGANENEMPVLKEKLQEWLNLNKRVSLNNAYD
HHHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHH
LLAEIRQAPVAV
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]