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The map label for this gene is hbd [H]

Identifier: 52842159

GI number: 52842159

Start: 2170297

End: 2171151

Strand: Reverse

Name: hbd [H]

Synonym: lpg1942

Alternate gene names: 52842159

Gene position: 2171151-2170297 (Counterclockwise)

Preceding gene: 52842160

Following gene: 52842158

Centisome position: 63.9

GC content: 36.96

Gene sequence:

>855_bases
ATGAAACAAAAAAAACTAACGCTTCTTGGTGCAGGAACAATGGGTTCAGGTATCGCACAGCTTTTTGCGCAATGCGGATT
TTATGTCACTTTAATCGATAACATCCAATCTCAACTGGATAAAGCAAAGACCACTATAGCTAAAAATTTACACTATCTGG
CATTAACTCAAAATTTAGCATTGACCCATTCTATTGAAACTATACTGGCATCAATTGCTTTTACAACACAATTAGATGAA
CTTAAGGAATCGGAATATATTATAGAAAATATCACTGAGAATTGGGAGCTAAAAAAAGCACTGTATCAGGTATTAAATGA
ACAAGGCAACCCAACCTGTATTTTGGGGGTAAACACCTCCTCTATACCTATTACTAAAATAGCATCGCTCGTTGAACATC
CCCAACGCGTTATAGGGGTTCATTTTATGAACCCAGCGACGATAATGCCTATGGTAGAAGTGATTAAGGGATATCACACT
GACGAATCGACAATAAAAAAAACCAGAACCTTACTTGAGCAAGTCCATAAAAAAATGATCGTTGTTAAGGACTCCGTTGG
TTTTGTGAGTAATCGTGCCATGATGATTTTTATTAACGAAGCCATTTTTATGGTACAGGAAAACATTGCATCAATCGAAG
ACATCGATGTTCTATTCAAACAATGCTTTGGGCATAAGATGGGGCCGCTGCATACTGCCGATTTAATTGGGTTGGATACG
GTTCTCTATTCTTTAGAAACAATCTATTCAGAGCTGAACGATCCAAAGTATCGACCATGCTGGTTATTAAAAAATATGGT
CGATGCAGGGCTTCTTGGACAAAAAACAAAAAAAGGATTTTATCAATATGAGTAG

Upstream 100 bases:

>100_bases
CCAAGAACCTTTATGCGGGATTTGGAACAAACGGCCAGAATTGAGCTTTTACTTGTAATCCAATACGAATAACTGTAATA
AGCTTTGGTGGACAAACGGC

Downstream 100 bases:

>100_bases
AATTGCAAACAGCCACTAAGGAGAGGAATTTTGCCCAACTATCAGCCTCGACAAGTGAAAAAACAACAGTTCTTTAATCA
ATTCATAGAAAATTGTCTTC

Product: 3-hydroxyacyl CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKQKKLTLLGAGTMGSGIAQLFAQCGFYVTLIDNIQSQLDKAKTTIAKNLHYLALTQNLALTHSIETILASIAFTTQLDE
LKESEYIIENITENWELKKALYQVLNEQGNPTCILGVNTSSIPITKIASLVEHPQRVIGVHFMNPATIMPMVEVIKGYHT
DESTIKKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLKNMVDAGLLGQKTKKGFYQYE

Sequences:

>Translated_284_residues
MKQKKLTLLGAGTMGSGIAQLFAQCGFYVTLIDNIQSQLDKAKTTIAKNLHYLALTQNLALTHSIETILASIAFTTQLDE
LKESEYIIENITENWELKKALYQVLNEQGNPTCILGVNTSSIPITKIASLVEHPQRVIGVHFMNPATIMPMVEVIKGYHT
DESTIKKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLKNMVDAGLLGQKTKKGFYQYE
>Mature_284_residues
MKQKKLTLLGAGTMGSGIAQLFAQCGFYVTLIDNIQSQLDKAKTTIAKNLHYLALTQNLALTHSIETILASIAFTTQLDE
LKESEYIIENITENWELKKALYQVLNEQGNPTCILGVNTSSIPITKIASLVEHPQRVIGVHFMNPATIMPMVEVIKGYHT
DESTIKKTRTLLEQVHKKMIVVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
VLYSLETIYSELNDPKYRPCWLLKNMVDAGLLGQKTKKGFYQYE

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=33.4494773519164, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=31.5789473684211, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI68989263, Length=289, Percent_Identity=31.1418685121107, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI261878539, Length=289, Percent_Identity=31.1418685121107, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI20127408, Length=289, Percent_Identity=30.4498269896194, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=31.063829787234, Blast_Score=105, Evalue=4e-23,
Organism=Escherichia coli, GI1787661, Length=282, Percent_Identity=31.5602836879433, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1788682, Length=218, Percent_Identity=34.8623853211009, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1790281, Length=220, Percent_Identity=28.6363636363636, Blast_Score=114, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=33.2179930795848, Blast_Score=174, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=293, Percent_Identity=33.1058020477816, Blast_Score=153, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=31.9444444444444, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=286, Percent_Identity=30.0699300699301, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=280, Percent_Identity=30, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=29.4326241134752, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508953, Length=281, Percent_Identity=28.1138790035587, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=28.1138790035587, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=281, Percent_Identity=28.1138790035587, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=26.4248704663212, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=193, Percent_Identity=26.4248704663212, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=29.3706293706294, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=29.3706293706294, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=29.3706293706294, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI20129993, Length=244, Percent_Identity=30.7377049180328, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45549573, Length=239, Percent_Identity=30.9623430962343, Blast_Score=110, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31934; Mature: 31934

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKKLTLLGAGTMGSGIAQLFAQCGFYVTLIDNIQSQLDKAKTTIAKNLHYLALTQNLA
CCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
LTHSIETILASIAFTTQLDELKESEYIIENITENWELKKALYQVLNEQGNPTCILGVNTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCC
SIPITKIASLVEHPQRVIGVHFMNPATIMPMVEVIKGYHTDESTIKKTRTLLEQVHKKMI
CCCHHHHHHHHHCHHHHHEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEE
VVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
EEECCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VLYSLETIYSELNDPKYRPCWLLKNMVDAGLLGQKTKKGFYQYE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCC
>Mature Secondary Structure
MKQKKLTLLGAGTMGSGIAQLFAQCGFYVTLIDNIQSQLDKAKTTIAKNLHYLALTQNLA
CCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
LTHSIETILASIAFTTQLDELKESEYIIENITENWELKKALYQVLNEQGNPTCILGVNTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCC
SIPITKIASLVEHPQRVIGVHFMNPATIMPMVEVIKGYHTDESTIKKTRTLLEQVHKKMI
CCCHHHHHHHHHCHHHHHEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEE
VVKDSVGFVSNRAMMIFINEAIFMVQENIASIEDIDVLFKQCFGHKMGPLHTADLIGLDT
EEECCCCHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
VLYSLETIYSELNDPKYRPCWLLKNMVDAGLLGQKTKKGFYQYE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]