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The map label for this gene is kefC [H]

Identifier: 52842115

GI number: 52842115

Start: 2114993

End: 2116798

Strand: Direct

Name: kefC [H]

Synonym: lpg1897

Alternate gene names: 52842115

Gene position: 2114993-2116798 (Clockwise)

Preceding gene: 52842114

Following gene: 52842116

Centisome position: 62.25

GC content: 39.42

Gene sequence:

>1806_bases
ATGAACGGTCACTTACTCCTCAATGTTTTCATTTTCCTTGCTGCTGCAAGCATCATGGTTCCACTGGCAAGCCGATTTAG
ACTTGGTTCTGTGATTGGTTATCTTACCGTTGGGATGCTCATTGGACCTTTTGGACTTAAGCTAATAGGCAATGCCGAAC
AAATTATGCATTTTGCAGAATTTGGAGTAGTCATGATGTTATTCTTGATTGGTTTGGAATTAGAACCAATCATGCTCTGG
AAGCTGAGAAAATTAATAGTTGGCTTAGGGGGCTTGCAAGTGTTGTTAACAACAATCGCTCTGTCTTCGGCAGCTGTTAT
GATGGGATACAATTTGCGAGCCAGTGTCGCGGTCAGTATGGCACTTGCCCTATCTTCAACTGCTTTAGTCTTGCAAATGC
TCCAGGAGAAAAATCTTTTGAAAACCGCGGAGGGTGAAACTTCTTTTGCTGTTCTCTTATTCCAGGATATTGCGGTCATT
CCAATCTTGGTGATTTTGCCTTTATTAGGCAATCATCATGGAATTAATGTGGCTATTAACCCTCATACGGCTGCCTCTAT
TGCTCAATTACCCAAGTGGCTTCACGCTATTGTCGTTGCCGGCATTATCGGTAGCATTGTTTTGGCGGGACACTACTTAT
CCAGATACTTGTTCCTAATCATTGCAAAAACCAATATCCGTGAAGTATTTACAGCATTTTCCTTATCCCTGGTCGTTGGA
ATTACCTTGTTAATGGAAACAATTGGGGTGTCTCCGGCTTTGGGAGCTTTTATCGCAGGTATGGTTTTAGCTAACTCTCA
ATATAAACGGACTGTAGAAGCTGATATCCAACCTTTCAAAGGACTGCTTCTTGGATTATTTTTCATCTCAGTCGGAATGG
GTATCAACTTCAATCTACTCTTCAGTCAAATGGCTGTAATCATCCCTATTGTACTCGGTTTGATTACCATTAAGGCATTG
ATTCTCTTTACGCTCGGCAAGATATTTCAACTCACTAAAATACAGGCGCTCGGATTCGCCCTTGGTTTATCACAGGGTGG
AGAATTTGCCTTTGTTCTTTTTCAATACTCCAGCACATTAAAAGTAATCAGCCCGGAAATAAACAGTTTTTTTACTCTGG
TAGTCGCCCTGTCCATGTTGGCCACACCCTTTTTAATGCTTTTGTACCATCGTTTTATGATACCGAAATTAATAAGCAAA
TTACCAGAACGTGAATACGACTCTATTCATGAAAAAAATAACATTATTATAGCTGGTTACGGTCGATTTGGTCAGATAAT
TGGTCGATTTCTTAGTGGTGAAAACATCAAGGTAACCGTTTTGGAAAAAAATCCGGAGCAAGTCGAATTATTAAGAAAAT
TTGGCTACACCGGATATTTTGGTGATGCGAATCGTCTGGACCTGCTAAAAAGCGCAGGAGCAGCGCATGCTCAATTGCTC
ATAGTCACAGTCGGGAATCCCGACACCAATTTGGAAATTGTGAAATTAGCTAAAGAAGAGTTTCCTCAATTGAAAATTTT
TGCCCGAGCAAGAAATAGACGACACGCCTATGAGTTACATAAAGCAGGAGTTCATTATTTCAAAAGAGAGTTATTTGACT
CTTCGTTAACCATGACCAAGGAAATTTTAAAATTTCTTGGTTATAAACCTGAAGAAATTGAGAAAAAAGCCAATGCTTTC
CAAAAACACGATGAAGAAACATTAATTAAATCTTTTGATTTTTTTGAGGAAGAAGCCAATCTCATCAATTTCTCACGTCA
GGCAAAAGGAGAATTAGAGCGTATTTTGCAAAATAATAATCCATAA

Upstream 100 bases:

>100_bases
CAAGACAAGCAAAAGATAGGCCGCAATAGCCCATGTCCCTGTGGAAGCGGTAAAAAATTTAAAAACTGTCATGATAAATG
AATTAAACTCAAGGTAGCAG

Downstream 100 bases:

>100_bases
TCAAATCATAAAGGTCTATACTTCCATATAATCATCTTGAAATGGCTTTCATTATGATAAAACAATTACAACAGGCATTA
AGTGATATTCTTTTAGGAAA

Product: glutathione-regulated potassium efflux system

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MNGHLLLNVFIFLAAASIMVPLASRFRLGSVIGYLTVGMLIGPFGLKLIGNAEQIMHFAEFGVVMMLFLIGLELEPIMLW
KLRKLIVGLGGLQVLLTTIALSSAAVMMGYNLRASVAVSMALALSSTALVLQMLQEKNLLKTAEGETSFAVLLFQDIAVI
PILVILPLLGNHHGINVAINPHTAASIAQLPKWLHAIVVAGIIGSIVLAGHYLSRYLFLIIAKTNIREVFTAFSLSLVVG
ITLLMETIGVSPALGAFIAGMVLANSQYKRTVEADIQPFKGLLLGLFFISVGMGINFNLLFSQMAVIIPIVLGLITIKAL
ILFTLGKIFQLTKIQALGFALGLSQGGEFAFVLFQYSSTLKVISPEINSFFTLVVALSMLATPFLMLLYHRFMIPKLISK
LPEREYDSIHEKNNIIIAGYGRFGQIIGRFLSGENIKVTVLEKNPEQVELLRKFGYTGYFGDANRLDLLKSAGAAHAQLL
IVTVGNPDTNLEIVKLAKEEFPQLKIFARARNRRHAYELHKAGVHYFKRELFDSSLTMTKEILKFLGYKPEEIEKKANAF
QKHDEETLIKSFDFFEEEANLINFSRQAKGELERILQNNNP

Sequences:

>Translated_601_residues
MNGHLLLNVFIFLAAASIMVPLASRFRLGSVIGYLTVGMLIGPFGLKLIGNAEQIMHFAEFGVVMMLFLIGLELEPIMLW
KLRKLIVGLGGLQVLLTTIALSSAAVMMGYNLRASVAVSMALALSSTALVLQMLQEKNLLKTAEGETSFAVLLFQDIAVI
PILVILPLLGNHHGINVAINPHTAASIAQLPKWLHAIVVAGIIGSIVLAGHYLSRYLFLIIAKTNIREVFTAFSLSLVVG
ITLLMETIGVSPALGAFIAGMVLANSQYKRTVEADIQPFKGLLLGLFFISVGMGINFNLLFSQMAVIIPIVLGLITIKAL
ILFTLGKIFQLTKIQALGFALGLSQGGEFAFVLFQYSSTLKVISPEINSFFTLVVALSMLATPFLMLLYHRFMIPKLISK
LPEREYDSIHEKNNIIIAGYGRFGQIIGRFLSGENIKVTVLEKNPEQVELLRKFGYTGYFGDANRLDLLKSAGAAHAQLL
IVTVGNPDTNLEIVKLAKEEFPQLKIFARARNRRHAYELHKAGVHYFKRELFDSSLTMTKEILKFLGYKPEEIEKKANAF
QKHDEETLIKSFDFFEEEANLINFSRQAKGELERILQNNNP
>Mature_601_residues
MNGHLLLNVFIFLAAASIMVPLASRFRLGSVIGYLTVGMLIGPFGLKLIGNAEQIMHFAEFGVVMMLFLIGLELEPIMLW
KLRKLIVGLGGLQVLLTTIALSSAAVMMGYNLRASVAVSMALALSSTALVLQMLQEKNLLKTAEGETSFAVLLFQDIAVI
PILVILPLLGNHHGINVAINPHTAASIAQLPKWLHAIVVAGIIGSIVLAGHYLSRYLFLIIAKTNIREVFTAFSLSLVVG
ITLLMETIGVSPALGAFIAGMVLANSQYKRTVEADIQPFKGLLLGLFFISVGMGINFNLLFSQMAVIIPIVLGLITIKAL
ILFTLGKIFQLTKIQALGFALGLSQGGEFAFVLFQYSSTLKVISPEINSFFTLVVALSMLATPFLMLLYHRFMIPKLISK
LPEREYDSIHEKNNIIIAGYGRFGQIIGRFLSGENIKVTVLEKNPEQVELLRKFGYTGYFGDANRLDLLKSAGAAHAQLL
IVTVGNPDTNLEIVKLAKEEFPQLKIFARARNRRHAYELHKAGVHYFKRELFDSSLTMTKEILKFLGYKPEEIEKKANAF
QKHDEETLIKSFDFFEEEANLINFSRQAKGELERILQNNNP

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=413, Percent_Identity=28.0871670702179, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786232, Length=563, Percent_Identity=44.2273534635879, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789749, Length=596, Percent_Identity=40.2684563758389, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1786685, Length=504, Percent_Identity=27.3809523809524, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66413; Mature: 66413

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGHLLLNVFIFLAAASIMVPLASRFRLGSVIGYLTVGMLIGPFGLKLIGNAEQIMHFAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEECCHHHHHHHHH
FGVVMMLFLIGLELEPIMLWKLRKLIVGLGGLQVLLTTIALSSAAVMMGYNLRASVAVSM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALALSSTALVLQMLQEKNLLKTAEGETSFAVLLFQDIAVIPILVILPLLGNHHGINVAIN
HHHHHHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PHTAASIAQLPKWLHAIVVAGIIGSIVLAGHYLSRYLFLIIAKTNIREVFTAFSLSLVVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ITLLMETIGVSPALGAFIAGMVLANSQYKRTVEADIQPFKGLLLGLFFISVGMGINFNLL
HHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FSQMAVIIPIVLGLITIKALILFTLGKIFQLTKIQALGFALGLSQGGEFAFVLFQYSSTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
KVISPEINSFFTLVVALSMLATPFLMLLYHRFMIPKLISKLPEREYDSIHEKNNIIIAGY
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEC
GRFGQIIGRFLSGENIKVTVLEKNPEQVELLRKFGYTGYFGDANRLDLLKSAGAAHAQLL
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEE
IVTVGNPDTNLEIVKLAKEEFPQLKIFARARNRRHAYELHKAGVHYFKRELFDSSLTMTK
EEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
EILKFLGYKPEEIEKKANAFQKHDEETLIKSFDFFEEEANLINFSRQAKGELERILQNNN
HHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
P
C
>Mature Secondary Structure
MNGHLLLNVFIFLAAASIMVPLASRFRLGSVIGYLTVGMLIGPFGLKLIGNAEQIMHFAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHEECCHHHHHHHHH
FGVVMMLFLIGLELEPIMLWKLRKLIVGLGGLQVLLTTIALSSAAVMMGYNLRASVAVSM
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALALSSTALVLQMLQEKNLLKTAEGETSFAVLLFQDIAVIPILVILPLLGNHHGINVAIN
HHHHHHHHHHHHHHHHCCHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PHTAASIAQLPKWLHAIVVAGIIGSIVLAGHYLSRYLFLIIAKTNIREVFTAFSLSLVVG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ITLLMETIGVSPALGAFIAGMVLANSQYKRTVEADIQPFKGLLLGLFFISVGMGINFNLL
HHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
FSQMAVIIPIVLGLITIKALILFTLGKIFQLTKIQALGFALGLSQGGEFAFVLFQYSSTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
KVISPEINSFFTLVVALSMLATPFLMLLYHRFMIPKLISKLPEREYDSIHEKNNIIIAGY
EEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCEEEEEC
GRFGQIIGRFLSGENIKVTVLEKNPEQVELLRKFGYTGYFGDANRLDLLKSAGAAHAQLL
CHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCEEEEE
IVTVGNPDTNLEIVKLAKEEFPQLKIFARARNRRHAYELHKAGVHYFKRELFDSSLTMTK
EEEECCCCCCHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHH
EILKFLGYKPEEIEKKANAFQKHDEETLIKSFDFFEEEANLINFSRQAKGELERILQNNN
HHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA