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The map label for this gene is mltB [H]

Identifier: 52842094

GI number: 52842094

Start: 2094213

End: 2095256

Strand: Direct

Name: mltB [H]

Synonym: lpg1873

Alternate gene names: 52842094

Gene position: 2094213-2095256 (Clockwise)

Preceding gene: 52842089

Following gene: 52842095

Centisome position: 61.64

GC content: 39.37

Gene sequence:

>1044_bases
GTGCTTTGCAACGATACAGGGTACATGATGCGACAAATCATCTGGCTAGGTTTCATTTCACTCTTCCTTTTATCTTTCAC
TACCTATTCCGACACAACTTTTACAAAACGTAAAGACGTACAATCGTTTATTAACATGATGGTAACGAATTATCACTTTA
ATCGTAATCAGTTAACTACAGTAATGAACCAAGTTAAACTTCAACCACAAGTCATCGAATCTATGGAAAAGCCCTATGAA
AAGAAAAACTGGGATGTCTACCGAGAACTGTTTCTTACTCAGAAAAGATTAAAAAGCGGATTGCAATTTTGGGCTGAAAA
TCAAAAAACATTGGAAAAAATTCAGAGAAGATATGGGGTGTCTCCGGAGATCATTATAGCTATTTTAGGAGTAGAGACAA
TGTATGGTGAGCGTCAGGGTGAATACAGAGTCTTGGATACTCTGGCTACACTGGCTTTCAACTACCCCAAACGTTCTGCA
TTCTTTACTAAAGAATTAAAGGAGTTTTTCCTCCTGTGCCGAGAACAGCACGTATCCCCAACTCAATACAAAGGGTCTTA
CGCAGGTGCCATAGGAAAACCCCAATTTATGCCAAGCAGTTATCGATATTATGCAGTGGACTTTAATAACAATGGTCGAA
GAGATTTAGTCAATGACAATGGTGACTCTATTGCCAGCATCGCCAATTATTTGCATAAACATGGTTGGAACTTAAATCAA
GGCATCGCTCAACCGGCCAAAATCTCCGGATGGCGATACAAACAACTTCGCATGAACCCTAAAACAGCAAATTACCGATA
CTCACAACTTATAAGCTATGGAGTAAAACCAATTACAGCGTCACAAAATCATCCTCCTCGTGCAGGAGTCATTGAGTTAG
TTACAAGGAAGGGTAAAGAATACTGGATTGCCTACCCCAATTTTTTTGTAATTACCCGCTATAATTCGAGCCCTCAATAT
GCTCTGGCGGTTTACTTATTATCCCAGCAATTGAAGCAACATTGGTATACTAGTGCCACCAAAAAGCACAGAGCTTATGT
TTAA

Upstream 100 bases:

>100_bases
GAGAATGAAAATTGCTTATTCATTTACCAATTTCATGCACTGTATTTAAGATAAACAAAAGTCAAAAGTTTGCTATGAGG
CTTTATTTTTACTAAAATTC

Downstream 100 bases:

>100_bases
TGCCAGCTGGAAATAATAATAATTACTGGTATATACTGAAAAATTGACAGCCATAACAATACAGAGTTTGACTTATGGAT
AAGTGTTTTATTTTTAGCAA

Product: membrane bound lytic murein transglycosylase

Products: Muramic Acid Residue [C]

Alternate protein names: 35 kDa soluble lytic transglycosylase; Murein hydrolase B; Slt35 [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLCNDTGYMMRQIIWLGFISLFLLSFTTYSDTTFTKRKDVQSFINMMVTNYHFNRNQLTTVMNQVKLQPQVIESMEKPYE
KKNWDVYRELFLTQKRLKSGLQFWAENQKTLEKIQRRYGVSPEIIIAILGVETMYGERQGEYRVLDTLATLAFNYPKRSA
FFTKELKEFFLLCREQHVSPTQYKGSYAGAIGKPQFMPSSYRYYAVDFNNNGRRDLVNDNGDSIASIANYLHKHGWNLNQ
GIAQPAKISGWRYKQLRMNPKTANYRYSQLISYGVKPITASQNHPPRAGVIELVTRKGKEYWIAYPNFFVITRYNSSPQY
ALAVYLLSQQLKQHWYTSATKKHRAYV

Sequences:

>Translated_347_residues
MLCNDTGYMMRQIIWLGFISLFLLSFTTYSDTTFTKRKDVQSFINMMVTNYHFNRNQLTTVMNQVKLQPQVIESMEKPYE
KKNWDVYRELFLTQKRLKSGLQFWAENQKTLEKIQRRYGVSPEIIIAILGVETMYGERQGEYRVLDTLATLAFNYPKRSA
FFTKELKEFFLLCREQHVSPTQYKGSYAGAIGKPQFMPSSYRYYAVDFNNNGRRDLVNDNGDSIASIANYLHKHGWNLNQ
GIAQPAKISGWRYKQLRMNPKTANYRYSQLISYGVKPITASQNHPPRAGVIELVTRKGKEYWIAYPNFFVITRYNSSPQY
ALAVYLLSQQLKQHWYTSATKKHRAYV
>Mature_347_residues
MLCNDTGYMMRQIIWLGFISLFLLSFTTYSDTTFTKRKDVQSFINMMVTNYHFNRNQLTTVMNQVKLQPQVIESMEKPYE
KKNWDVYRELFLTQKRLKSGLQFWAENQKTLEKIQRRYGVSPEIIIAILGVETMYGERQGEYRVLDTLATLAFNYPKRSA
FFTKELKEFFLLCREQHVSPTQYKGSYAGAIGKPQFMPSSYRYYAVDFNNNGRRDLVNDNGDSIASIANYLHKHGWNLNQ
GIAQPAKISGWRYKQLRMNPKTANYRYSQLISYGVKPITASQNHPPRAGVIELVTRKGKEYWIAYPNFFVITRYNSSPQY
ALAVYLLSQQLKQHWYTSATKKHRAYV

Specific function: Murein-degrading enzyme. Catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N- acetylglucosamine residues in peptidoglycan. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG2951

COG function: function code M; Membrane-bound lytic murein transglycosylase B

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor; Periplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789053, Length=314, Percent_Identity=38.8535031847134, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011757 [H]

Pfam domain/function: NA

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40736; Mature: 40736

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLCNDTGYMMRQIIWLGFISLFLLSFTTYSDTTFTKRKDVQSFINMMVTNYHFNRNQLTT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
VMNQVKLQPQVIESMEKPYEKKNWDVYRELFLTQKRLKSGLQFWAENQKTLEKIQRRYGV
HHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
SPEIIIAILGVETMYGERQGEYRVLDTLATLAFNYPKRSAFFTKELKEFFLLCREQHVSP
CHHHEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TQYKGSYAGAIGKPQFMPSSYRYYAVDFNNNGRRDLVNDNGDSIASIANYLHKHGWNLNQ
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
GIAQPAKISGWRYKQLRMNPKTANYRYSQLISYGVKPITASQNHPPRAGVIELVTRKGKE
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCE
YWIAYPNFFVITRYNSSPQYALAVYLLSQQLKQHWYTSATKKHRAYV
EEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLCNDTGYMMRQIIWLGFISLFLLSFTTYSDTTFTKRKDVQSFINMMVTNYHFNRNQLTT
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
VMNQVKLQPQVIESMEKPYEKKNWDVYRELFLTQKRLKSGLQFWAENQKTLEKIQRRYGV
HHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
SPEIIIAILGVETMYGERQGEYRVLDTLATLAFNYPKRSAFFTKELKEFFLLCREQHVSP
CHHHEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
TQYKGSYAGAIGKPQFMPSSYRYYAVDFNNNGRRDLVNDNGDSIASIANYLHKHGWNLNQ
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
GIAQPAKISGWRYKQLRMNPKTANYRYSQLISYGVKPITASQNHPPRAGVIELVTRKGKE
CCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCE
YWIAYPNFFVITRYNSSPQYALAVYLLSQQLKQHWYTSATKKHRAYV
EEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7476170; 7789526; 9205837; 9278503; 3553176; 9761817; 10570954; 10545329; 10684641 [H]