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The map label for this gene is clpP

Identifier: 52842086

GI number: 52842086

Start: 2084215

End: 2084859

Strand: Reverse

Name: clpP

Synonym: lpg1861

Alternate gene names: 52842086

Gene position: 2084859-2084215 (Counterclockwise)

Preceding gene: 52842087

Following gene: 52842085

Centisome position: 61.36

GC content: 40.47

Gene sequence:

>645_bases
ATGCCAGGCTATTCAGATAATATTATCCGTAATGCAAGCGGATTAATACCAATGGTCATTGAGCAAACCTCGCGAGGTGA
GCGTTCCTATGACATTTACTCAAGATTATTAAAAGAAAGAATTATTTTTCTCTTGGGTGAAGTAGAAGATCATATGGCTA
ACCTGGTTGTGGCTCAGTTGTTGTTTCTGGAGTCTGAAAATCCAGAGAAAGATATATCTCTATATATTAATTCTCCCGGC
GGAGTCGTTACTGCAGGTCTTGCTATCTACGACACCATGCAATTTATTAAGCCAGATGTAAGTACATTATGCATAGGCCA
GGCAGCAAGTGCAGCTGCCTTGCTACTTTGTGCCGGTGCTGAAGGCAAACGATTCTGCTTACCTAACTCAAGAGTTATGA
TACATCAGCCCTTGGGTGGCTATAGAGGTCAAGCAACAGACATAGAAATTCATGCTCGAGAGACCTTGGCAGTTAGGGAA
CGTTTGAATAATATTATGGCTAAACACACTAAAAAAACACCTGATCAAATCATGCGTGATACAGAAAGAGATAACTTTAT
GAGTGCTACTCAGGCTATGGAGTATGGTCTAATCGATAAAGTTCTCTATGACAGACAAGTTGCTGGACATTCTACAGACT
TATAA

Upstream 100 bases:

>100_bases
CTGATAAAATAGCAGAAGATGCGAAACTTAAATACAAAAATATGGATTATGATTCAGTGATGAATCCCAAAAAGGGCACT
GAGAAAAAAGGAGAGTAAGC

Downstream 100 bases:

>100_bases
CTTTGCTAGATACTCCTAGTTTATCTGAGTATAATATAAGTTGGTTTGATAGTAATGTGGTGGCGCAATATTATCTGATT
GTCTAAAATTTTACATGTAA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPG
GVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGAEGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRE
RLNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL

Sequences:

>Translated_214_residues
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPG
GVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGAEGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRE
RLNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL
>Mature_213_residues
PGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQLLFLESENPEKDISLYINSPGG
VVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGAEGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRER
LNNIMAKHTKKTPDQIMRDTERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=61.1702127659574, Blast_Score=242, Evalue=2e-64,
Organism=Escherichia coli, GI1786641, Length=203, Percent_Identity=73.8916256157635, Blast_Score=320, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.3010752688172, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI20129427, Length=200, Percent_Identity=60, Blast_Score=248, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_LEGPA (Q5X451)

Other databases:

- EMBL:   CR628336
- RefSeq:   YP_124147.1
- ProteinModelPortal:   Q5X451
- SMR:   Q5X451
- STRING:   Q5X451
- GeneID:   3118093
- GenomeReviews:   CR628336_GR
- KEGG:   lpp:lpp1829
- LegioList:   lpp1829
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- ProtClustDB:   PRK00277
- BioCyc:   LPNE297246:LPP1829-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23776; Mature: 23644

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 110-110 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQL
CCCCCCCHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLESENPEKDISLYINSPGGVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGA
HHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEEECC
EGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRERLNNIMAKHTKKTPDQIMRD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PGYSDNIIRNASGLIPMVIEQTSRGERSYDIYSRLLKERIIFLLGEVEDHMANLVVAQL
CCCCCCHHHCCCCCCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFLESENPEKDISLYINSPGGVVTAGLAIYDTMQFIKPDVSTLCIGQAASAAALLLCAGA
HHHCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHCCCHHHHHHCCHHHHHEEEEEECC
EGKRFCLPNSRVMIHQPLGGYRGQATDIEIHARETLAVRERLNNIMAKHTKKTPDQIMRD
CCCEEECCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
TERDNFMSATQAMEYGLIDKVLYDRQVAGHSTDL
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA