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The map label for this gene is pyrD

Identifier: 52842048

GI number: 52842048

Start: 2039223

End: 2040389

Strand: Reverse

Name: pyrD

Synonym: lpg1821

Alternate gene names: 52842048

Gene position: 2040389-2039223 (Counterclockwise)

Preceding gene: 52842049

Following gene: 52842047

Centisome position: 60.05

GC content: 37.1

Gene sequence:

>1167_bases
ATGAGCAAGTCATTTCGCTATTTATCTGGGCAGATGCATAAAAAATTATCTGAATTAATTTTATTTCGCTTCCTATTAAT
CGTCAGTACGAAAATCATCACGAAAAATGTTATCATACCTCAATTGTTCTTTATTAATGATTCTCCCTGCTTTAGGAGTA
ATTTTATGTATTCACTGCTGCGCCCTTTACTTTTCAGATTGGATGCAGAAAAAGCCCATTCATTAACATTATCCTTATTA
CATTACCTCCCTGGTTTTTATTTTCGGAAAATAGCCGGTCAACCTGTTCATGCTATGGGTCTTGTATTCCCTCATCAAGT
TGGACTGGCAGCTGGTTTAGATAAAAATGGCGAACATTTGGATGCATTAGCCAAATTGGGATTTTCATTCATTGAATTAG
GGACAGTAACACCTAAGGGACAAGCAGGTAATCCCAAACCAAGGCTTTTTCGTATTGCAGAGGCAAATGCGATTATCAAC
AGGATGGGTTTTAACAATTCGGGAGTTGATGTACTGGTAGAAAATGTAAAAAGAGCAAATTATAAAGGAATATTAGGGAT
AAATATTGGAAAAAATAAAGAGACTAATTTAAATCAAGCTGCAGAGGACTATCTTTATTGCTTCCGTAAAGTATATGATC
ATGCTTCCTATGTCACTATCAATATTTCCTCTCCCAATACCCCTGATTTACGCCAGTTACAACAAGGAGATTATTTTGCT
GAATTACTCACCCAGTTACAAAAAGAACAGATAAAATTAGCAGATCAATATGGACGCCATGTGCCTTTAGTGGTGAAAGT
ATCTCCGGATGAAACAGATGAAACACTAAAACAAATGACAGATATCATTTTACAGTATGGAATCGAGGGTATTATTGCAA
CGAATACCACCTGTTCTCGGGAAATGGTAAAAAATTTGCCTTGTTCTGAAGAACAGGGCGGATTAAGTGGTAGGCCACTG
ATGGAATTATCTACTCGCTGCTTGCGCTTGTTGAAACAATATGTTGGTAATGATGTGACATTGATAGGAGTGGGTGGTAT
TGACAGTTTGGAGAGCGCCAAAGACAAGATCAATGCAGGAGCTTCGTTATTACAAGTATACAGTGGTTTAGTTTATAAGG
GACCGGAGTTGATTCACGATATTGTTTCAGGTTTAAATGCTATCTGA

Upstream 100 bases:

>100_bases
CGATTAATAGAGACGCGCCTATGATTTTCCCTTTTAGACAGGGAGAATAGCCTATCAGCAGAATAAGCTCGTTTATGCAA
CAGGACTATTTGCAATCATA

Downstream 100 bases:

>100_bases
TCCTGGTGGTGAGGAAATCGATGTATATTACTAAGGAATTGGCTGTTCGCATGGAAGGGTGTATCAAGCAGAGTCACATT
GAGGTGACAAAGCGGTACTC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MSKSFRYLSGQMHKKLSELILFRFLLIVSTKIITKNVIIPQLFFINDSPCFRSNFMYSLLRPLLFRLDAEKAHSLTLSLL
HYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIIN
RMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFA
ELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSREMVKNLPCSEEQGGLSGRPL
MELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGPELIHDIVSGLNAI

Sequences:

>Translated_388_residues
MSKSFRYLSGQMHKKLSELILFRFLLIVSTKIITKNVIIPQLFFINDSPCFRSNFMYSLLRPLLFRLDAEKAHSLTLSLL
HYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIIN
RMGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFA
ELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSREMVKNLPCSEEQGGLSGRPL
MELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGPELIHDIVSGLNAI
>Mature_387_residues
SKSFRYLSGQMHKKLSELILFRFLLIVSTKIITKNVIIPQLFFINDSPCFRSNFMYSLLRPLLFRLDAEKAHSLTLSLLH
YLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHLDALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINR
MGFNNSGVDVLVENVKRANYKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFAE
LLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSREMVKNLPCSEEQGGLSGRPLM
ELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAGASLLQVYSGLVYKGPELIHDIVSGLNAI

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=334, Percent_Identity=41.9161676646707, Blast_Score=229, Evalue=4e-60,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=50.9036144578313, Blast_Score=345, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17509475, Length=345, Percent_Identity=35.6521739130435, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI281361352, Length=353, Percent_Identity=38.5269121813031, Blast_Score=231, Evalue=4e-61,
Organism=Drosophila melanogaster, GI17137316, Length=353, Percent_Identity=38.5269121813031, Blast_Score=231, Evalue=4e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 43153; Mature: 43021

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSFRYLSGQMHKKLSELILFRFLLIVSTKIITKNVIIPQLFFINDSPCFRSNFMYSLL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHH
RPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHL
HHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
DALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRAN
HHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCC
YKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCHHH
ELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSR
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHH
EMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAG
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCC
ASLLQVYSGLVYKGPELIHDIVSGLNAI
HHHHHHHHCHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKSFRYLSGQMHKKLSELILFRFLLIVSTKIITKNVIIPQLFFINDSPCFRSNFMYSLL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHH
RPLLFRLDAEKAHSLTLSLLHYLPGFYFRKIAGQPVHAMGLVFPHQVGLAAGLDKNGEHL
HHHHHHHCHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
DALAKLGFSFIELGTVTPKGQAGNPKPRLFRIAEANAIINRMGFNNSGVDVLVENVKRAN
HHHHHCCHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHHHHHCC
YKGILGINIGKNKETNLNQAAEDYLYCFRKVYDHASYVTINISSPNTPDLRQLQQGDYFA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCCCHHH
ELLTQLQKEQIKLADQYGRHVPLVVKVSPDETDETLKQMTDIILQYGIEGIIATNTTCSR
HHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCHHHH
EMVKNLPCSEEQGGLSGRPLMELSTRCLRLLKQYVGNDVTLIGVGGIDSLESAKDKINAG
HHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCC
ASLLQVYSGLVYKGPELIHDIVSGLNAI
HHHHHHHHCHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA