| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
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The map label for this gene is lysC
Identifier: 52842038
GI number: 52842038
Start: 2024508
End: 2027087
Strand: Direct
Name: lysC
Synonym: lpg1811
Alternate gene names: 52842038
Gene position: 2024508-2027087 (Clockwise)
Preceding gene: 52842036
Following gene: 52842039
Centisome position: 59.58
GC content: 41.24
Gene sequence:
>2580_bases TTGAGCGGAATACTAATCATGCAACAAGTAGTCATCAAATTTGGCGGCACTAGTGTTTCAACCAGAGCCACTTGGAATAA TATTGCTGCAATTACCCAAAAACATCTGAACACAGGTGTTCAGCCCGTTATAGTCTGTTCTGCTTTAACTCAAATTTCCA ACAAACTTGAAAAAGCCATAGAGGCAGCCCTTCTTGACGAGCATCATAGCCTTTTCAATGACATTCAGAGCAGTCACCTG AATCTGGCAGAACAATTAGAAGTAAACCATCAATTAATTGCTAATGATTTGCACCAATTACAGCAATGGCTAACCGGGAT CTCCTTACTCAAACAAGCACCTGCAAAAACACATGCGCAAATTTTAAGTTTGGGTGAGCTGATGATGACCCGCCTGGGCC ATGCCTTTCTTGAAAAACAAGGGATTAAAGTAAAATGGTATGATGCCAGAGAATTGTTAACAAGCACACCAACCCTTGGT GGAGAAACAATGAACTATCTCTCTGCCCGTTGTGAGAGTGAATACGACTCGGCATTGGTAGAAAAATTTCTCTCCAGTGG GGCTCAAGCCATTATTACCCAAGGTTTTTTTGCTGCCAATCCTCATGGTGAAACCGTTTTGCTTGGTCGAGGAGGCTCTG ATACTTCAGCAGCACTACTTGCGGGAAAACTACAGGCCGCTTCTTGTGAAATATGGACTGATGTCCCAGGCATTTATACC GCCAACCCGCATCAATTACCCCACGCCCGATTATTAAAGCAATTAAATTATGATGAAGCTCAGGAAATTGCCTCAATGGG GGCCAAAGTTTTACACCCCAATTGCATACCACCTGTTCGAAAAGCCAATATCCCTATGGTAGTCAAATACACTCACCTGC CTGAACATTCAGGAACATTGATTACCAAAGACATTGATGAATCGGCACCCTTAATAAAATCCATCCAGGTTAAGCACAGC ATACTGCTAATTTCTATAGACACTTTGAATATGTGGCAACAAGTAGGATTTCTGGCTGATGTATTTGCCGCCTTTAAAAA GCATGGGTTTTCAGTTGATTTGCTTTCTTCTTCTGAATTCAATGTCACCCTATCCCTGGATGTTAATGCCAAAATACATG ATAGACCAGCAATTAATGCCTTGCTCGACGATTTAAACCAATTTGGACGCGCCAAACTGATAGAACCCTGTAGTGCTGTC AGTTTGGTAGGACATCACATCCGAACTGTATTACCTCATCTTGGCCCGGCTTTGGAAGTATTTGAGGCAAAACAAGTATA CCTGATGTCTCTGGCCTCGAATGACCTTAATTTGACTTTTGTTGTTGATGAATCACATGCCGATAAATTATGCCAAAGAT TGCATCATCTACTAATCGAAAGTAATCCTCAAATCTTTTATTACTCCAAAAGCTGGCATGAAGAATTTGGCAAACCCAAT GTTCGCCCAACACCTTGGTGGGAAATTGAAAGAGACCGCTTGCTTACAACCAGCGCAATACATTCTCCTTGTTATGTTTA CCATAGTCCCACCCAGGCAACTCGTGCAAGACAATTATCTGCTCTGGAATCAATTGATAGCTTGTTTTACGCTATTAAAG CGAATCCATTCCCAACCATTTTAAAAACTCTGGAAAAAGAAGGGATAGGTTTTGAATGCGTTTCTATTCAGGAATTGGAA TTGGTGTTAAAACTGTTTCCCAATATTAAAAAAGAAAGAATTTTATTCACACCCAATTTCGCTCCCAAATCCGAGTATGA ATTTGCTTTGCAAACGGGCTGTTATGTGACTATTGATAGCTTATACCCTTTGGAAAATTGGCCTGACTTGTTTAAAGACC GCGAAGTAATCGTTCGCATAGATCCTGGTACAGGAGCTGGCCATCACAAGCACGTTTCTACTGGTGGAAATGAATCCAAA TTTGGTATAACACAAAATGACATAAGCAAGATTCTATCACTTACCAAAGTCAACCACATTAAGGTCATAGGCTTACATGC TCATTCTGGTAGTGGCATACTCTCAACGGATTTATGGCAACAAACTGCCGTGATGCTTGCCTCCCTAACCGATCAATTTC CTGAAGTGCGTTCAATTAATTTAGGTGGCGGTCTAGGTATTGTAGAAAAACCGGGCCAACATCCCATTGATTTTGCTGCG CTTGACGCGCAATTAATGGCAGTAAAATCTCAATATCCAGGATTAGCAATCTGGCTTGAACCAGGTCGCTTCTTTGTAGC TGAAAGTGGTGTCATTCTTGCCAAAGTAACGCAATGCAAAGAAAAAGGAAAAGTAAAATTTATTGGTATTGAAACAGGAA TGAACTCATTGATAAGGCCTTCCTTATATGGTGCGTATCATGAAATTGTCAATTTAACTCGACTACATGAAGAAAAGGCC GGGTTTGCTCATATAGTTGGCCCAATCTGTGAGTCGGGAGATACATTGGGTTATGACCGCTTATTACCAGTTACCAGAGA AGGCGATGTGATATTAATTGCAAACACTGGAGCCTATGGTCACTGTATGAGTTCACACTACAATTTAAGACCACCTGCTC AGGAAATAGTTCTGGAATAA
Upstream 100 bases:
>100_bases ACTCAACTCGTGACTTGGGTTGTCTTGAGAAAAATCTTTTTTAAATTGGGGCTTAATCTACTTGTACAAATACTTTAGTC CATGCTAAGGTGTATTAATT
Downstream 100 bases:
>100_bases TGGCATGCGGTTAATTGATAGTGAACAAAGGAGCCAAGCGACAGATCCTGCTGAATCATTTATAGTCCAGGCTCCTGCCG GGTCAGGAAAAACAGAGATT
Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein
Products: NA
Alternate protein names: DAP decarboxylase [H]
Number of amino acids: Translated: 859; Mature: 858
Protein sequence:
>859_residues MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHL NLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRLGHAFLEKQGIKVKWYDARELLTSTPTLG GETMNYLSARCESEYDSALVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHS ILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAV SLVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQATRARQLSALESIDSLFYAIKANPFPTILKTLEKEGIGFECVSIQELE LVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPDLFKDREVIVRIDPGTGAGHHKHVSTGGNESK FGITQNDISKILSLTKVNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKA GFAHIVGPICESGDTLGYDRLLPVTREGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE
Sequences:
>Translated_859_residues MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHL NLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRLGHAFLEKQGIKVKWYDARELLTSTPTLG GETMNYLSARCESEYDSALVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHS ILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAV SLVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQATRARQLSALESIDSLFYAIKANPFPTILKTLEKEGIGFECVSIQELE LVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPDLFKDREVIVRIDPGTGAGHHKHVSTGGNESK FGITQNDISKILSLTKVNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKA GFAHIVGPICESGDTLGYDRLLPVTREGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE >Mature_858_residues SGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAIEAALLDEHHSLFNDIQSSHLN LAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQILSLGELMMTRLGHAFLEKQGIKVKWYDARELLTSTPTLGG ETMNYLSARCESEYDSALVEKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYTA NPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTLITKDIDESAPLIKSIQVKHSI LLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEFNVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVS LVGHHIRTVLPHLGPALEVFEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPNV RPTPWWEIERDRLLTTSAIHSPCYVYHSPTQATRARQLSALESIDSLFYAIKANPFPTILKTLEKEGIGFECVSIQELEL VLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDSLYPLENWPDLFKDREVIVRIDPGTGAGHHKHVSTGGNESKF GITQNDISKILSLTKVNHIKVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAAL DAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRPSLYGAYHEIVNLTRLHEEKAG FAHIVGPICESGDTLGYDRLLPVTREGDVILIANTGAYGHCMSSHYNLRPPAQEIVLE
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0019
COG function: function code E; Diaminopimelate decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]
Homologues:
Organism=Homo sapiens, GI4505489, Length=360, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-14, Organism=Escherichia coli, GI1790455, Length=464, Percent_Identity=30.6034482758621, Blast_Score=191, Evalue=2e-49, Organism=Escherichia coli, GI1786183, Length=476, Percent_Identity=30.2521008403361, Blast_Score=189, Evalue=9e-49, Organism=Escherichia coli, GI1789203, Length=376, Percent_Identity=31.3829787234043, Blast_Score=186, Evalue=7e-48, Organism=Escherichia coli, GI1790376, Length=304, Percent_Identity=29.2763157894737, Blast_Score=114, Evalue=3e-26, Organism=Saccharomyces cerevisiae, GI6320893, Length=498, Percent_Identity=27.3092369477912, Blast_Score=155, Evalue=3e-38, Organism=Drosophila melanogaster, GI24586472, Length=343, Percent_Identity=26.2390670553936, Blast_Score=93, Evalue=9e-19, Organism=Drosophila melanogaster, GI24586474, Length=339, Percent_Identity=27.7286135693215, Blast_Score=72, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009006 - InterPro: IPR002986 - InterPro: IPR022643 - InterPro: IPR022644 - InterPro: IPR022653 - InterPro: IPR000183 [H]
Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]
EC number: =4.1.1.20 [H]
Molecular weight: Translated: 94828; Mature: 94697
Theoretical pI: Translated: 6.73; Mature: 6.73
Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.4 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 1.4 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAI CCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH EAALLDEHHSLFNDIQSSHLNLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQ HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH ILSLGELMMTRLGHAFLEKQGIKVKWYDARELLTSTPTLGGETMNYLSARCESEYDSALV HHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH EKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT HHHHHCCCCEEHHCCCEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEE ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTL CCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE ITKDIDESAPLIKSIQVKHSILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEF EEECCCCCCCHHHHHEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE NVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVSLVGHHIRTVLPHLGPALEV EEEEEEEECCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHH FEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN HHHHHEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCC VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQATRARQLSALESIDSLFYAIKANPFPTI CCCCCCCCCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCHHHH LKTLEKEGIGFECVSIQELELVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDS HHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCEEEECC LYPLENWPDLFKDREVIVRIDPGTGAGHHKHVSTGGNESKFGITQNDISKILSLTKVNHI CCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEE KVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA EEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHH LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRP HHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEHHHHHHCCCEEEEEEECCCHHHHCH SLYGAYHEIVNLTRLHEEKAGFAHIVGPICESGDTLGYDRLLPVTREGDVILIANTGAYG HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHCCCEECCCCEEEEECCCCCH HCMSSHYNLRPPAQEIVLE HHHCCCCCCCCCHHHHCCC >Mature Secondary Structure SGILIMQQVVIKFGGTSVSTRATWNNIAAITQKHLNTGVQPVIVCSALTQISNKLEKAI CCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH EAALLDEHHSLFNDIQSSHLNLAEQLEVNHQLIANDLHQLQQWLTGISLLKQAPAKTHAQ HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH ILSLGELMMTRLGHAFLEKQGIKVKWYDARELLTSTPTLGGETMNYLSARCESEYDSALV HHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHH EKFLSSGAQAIITQGFFAANPHGETVLLGRGGSDTSAALLAGKLQAASCEIWTDVPGIYT HHHHHCCCCEEHHCCCEEECCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEECCCCCEE ANPHQLPHARLLKQLNYDEAQEIASMGAKVLHPNCIPPVRKANIPMVVKYTHLPEHSGTL CCCCCCCHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEE ITKDIDESAPLIKSIQVKHSILLISIDTLNMWQQVGFLADVFAAFKKHGFSVDLLSSSEF EEECCCCCCCHHHHHEEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCE NVTLSLDVNAKIHDRPAINALLDDLNQFGRAKLIEPCSAVSLVGHHIRTVLPHLGPALEV EEEEEEEECCEECCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCCCHHHH FEAKQVYLMSLASNDLNLTFVVDESHADKLCQRLHHLLIESNPQIFYYSKSWHEEFGKPN HHHHHEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCC VRPTPWWEIERDRLLTTSAIHSPCYVYHSPTQATRARQLSALESIDSLFYAIKANPFPTI CCCCCCCCCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEEECCCHHHH LKTLEKEGIGFECVSIQELELVLKLFPNIKKERILFTPNFAPKSEYEFALQTGCYVTIDS HHHHHHCCCCEEEECHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEECCCEEEECC LYPLENWPDLFKDREVIVRIDPGTGAGHHKHVSTGGNESKFGITQNDISKILSLTKVNHI CCCCCCCHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEE KVIGLHAHSGSGILSTDLWQQTAVMLASLTDQFPEVRSINLGGGLGIVEKPGQHPIDFAA EEEEEEECCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCHHH LDAQLMAVKSQYPGLAIWLEPGRFFVAESGVILAKVTQCKEKGKVKFIGIETGMNSLIRP HHHHHHHHHHCCCCEEEEECCCEEEEECCCEEEEEHHHHHHCCCEEEEEEECCCHHHHCH SLYGAYHEIVNLTRLHEEKAGFAHIVGPICESGDTLGYDRLLPVTREGDVILIANTGAYG HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHCCCEECCCCEEEEECCCCCH HCMSSHYNLRPPAQEIVLE HHHCCCCCCCCCHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9371463 [H]