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The map label for this gene is dsbD

Identifier: 52841908

GI number: 52841908

Start: 1870228

End: 1871607

Strand: Reverse

Name: dsbD

Synonym: lpg1680

Alternate gene names: 52841908

Gene position: 1871607-1870228 (Counterclockwise)

Preceding gene: 52841909

Following gene: 52841907

Centisome position: 55.08

GC content: 37.39

Gene sequence:

>1380_bases
TTGTTATTTATTACTTATTGGGACATTAAAATGAGAAAATTAATTGATTCGTTCATGATTTTATTACTGATATTTTTTAC
TCAGGCGGCGTGGTCATATACTCCTGGCTTTGAAAGTTCTAACCCGGATACTGTGATGCATTTTATTACAGGAAATAGTG
CTTTTGTTTATTTGAGTGCTTTTTTCGGATTAGGTATTTTGTTGGCTTTTACGCCCTGTGTTCTACCGATGGTTCCTATT
TTATCAGGAATTATTGTAGGACAAAATTCTATTTCTACAGGAAAAGCCTTTAAATTATCACTGAGTTATGTGACTGGAAT
GGCTATCACCTATGCAGGAGCAGGGATGCTTGCCGGGTATATGGGAAGTACAATCCAGACTGTAATGCAACGTCCAGTAG
TAATCACTTTATTCAGTGTTGTGTTTGTAGCCATGGCTCTTTCAATGTTTGGCTTTTTTGAATTGAAGTTTCCTACAAGC
CTTGGGAATCGGTTAAATAAAAACAATCAATTAGGGAAGCAGAGAAGTTATCTTTCTGTTGGAATAATGGGAGTTTTATC
CACTTTAATTGTTTCTCCTTGTGTTACCGCTCCTTTAATTGGTGTTTTAAGTTATATTGGTCAAAATGGCCAGGTCATAA
TGGGCGGATTGATTTTATTTGTTATGGCATTGGGGATGGGGGTTCCTCTGCTGATTGTTGGTGCGGGTTATGGTACTTTA
CTCCCAAAAGCAGGTTCCTGGATGCTTAAAATAAAACAATTGTTTGGTTTTATCATGTTGGGAATTGCCATATGGATGTT
ATCCCGGATTCTGAATCAGACCATTACGCACATTTTGTGGGCAGGATTACTCATGGTCGCCAGCATCAGTTTAGGTGCTT
TAAAATCACAAAACAATTGGCGTGGTTATTTGGCTCAGGGATTGGGTATTCTTGCTTTGATTTCAGGAGGTATTATTTTT
TACAACACCGCAATACCTTCAGTAAAAATAAAACAAGCGTCTGTAGAAAATAGCCCATTTATCAAGATTAATACCTTAAA
CGCTCTTCAACTGCAATTGGAGCAGGCTAAAAAAGTTAGAAAAGCAGTATTTCTTGATTTCTCAGCGGATTGGTGCGGTG
ACTGTCAGGAAATGGATACCAAAGTATTCAATCAACCAGAAATTCAAAAAGCTATGTCTGATTGGGTTAGCATTAAAGTG
GATATCAGTGATAAGAATGCAGAGGTTGATTCTATAAAAAAAGCTTTTGGTATTTATGGAACGCCAACGATGATATTTTT
TAATACATCGGGAGAGCCTATTACTCAAATGACTTCGGTTGGTTTGATTTCGCTATCAAAAATGCTTCAATTGCTCGAGC
AAGCGCGCCATTTGAGTTGA

Upstream 100 bases:

>100_bases
TAGAGTAAATTTGTCAACTTTCTCAGTAGGCTTCTTGCCAGCCCTGGCTATGCAAGAGGTCCAGTGTAGGTTACTTGTAC
TCTGATACAAGTATCTATCG

Downstream 100 bases:

>100_bases
AATAATAGACAATTTGCTACCGAAATTTGTTCTTAATAATTTGGGTATGGTTAATATTTGATAAATAAATCAAATTCAAA
CTGTACCCAAAATATTGAAA

Product: thiol:disulfide interchange protein DsbD

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MLFITYWDIKMRKLIDSFMILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPI
LSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTS
LGNRLNKNNQLGKQRSYLSVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTL
LPKAGSWMLKIKQLFGFIMLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIF
YNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKV
DISDKNAEVDSIKKAFGIYGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS

Sequences:

>Translated_459_residues
MLFITYWDIKMRKLIDSFMILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPI
LSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTS
LGNRLNKNNQLGKQRSYLSVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTL
LPKAGSWMLKIKQLFGFIMLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIF
YNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKV
DISDKNAEVDSIKKAFGIYGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS
>Mature_459_residues
MLFITYWDIKMRKLIDSFMILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSAFFGLGILLAFTPCVLPMVPI
LSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGYMGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTS
LGNRLNKNNQLGKQRSYLSVGIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTL
LPKAGSWMLKIKQLFGFIMLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNWRGYLAQGLGILALISGGIIF
YNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVRKAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKV
DISDKNAEVDSIKKAFGIYGTPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=386, Percent_Identity=35.4922279792746, Blast_Score=236, Evalue=3e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 50051; Mature: 50051

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFITYWDIKMRKLIDSFMILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSA
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
FFGLGILLAFTPCVLPMVPILSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGY
HHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYLSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCCCCCCHHHHHHHH
GIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
LPKAGSWMLKIKQLFGFIMLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGYLAQGLGILALISGGIIFYNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVR
HHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHH
KAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGIYG
HHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCC
TPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLFITYWDIKMRKLIDSFMILLLIFFTQAAWSYTPGFESSNPDTVMHFITGNSAFVYLSA
CEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCHHHHHHH
FFGLGILLAFTPCVLPMVPILSGIIVGQNSISTGKAFKLSLSYVTGMAITYAGAGMLAGY
HHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MGSTIQTVMQRPVVITLFSVVFVAMALSMFGFFELKFPTSLGNRLNKNNQLGKQRSYLSV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHHHHCCCCCCCCHHHHHHHH
GIMGVLSTLIVSPCVTAPLIGVLSYIGQNGQVIMGGLILFVMALGMGVPLLIVGAGYGTL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHH
LPKAGSWMLKIKQLFGFIMLGIAIWMLSRILNQTITHILWAGLLMVASISLGALKSQNNW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGYLAQGLGILALISGGIIFYNTAIPSVKIKQASVENSPFIKINTLNALQLQLEQAKKVR
HHHHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCCCCCEEEEECCHHHHHHHHHHHHHH
KAVFLDFSADWCGDCQEMDTKVFNQPEIQKAMSDWVSIKVDISDKNAEVDSIKKAFGIYG
HHHEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHCCCC
TPTMIFFNTSGEPITQMTSVGLISLSKMLQLLEQARHLS
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA