Click here to switch to the map view.

The map label for this gene is purM

Identifier: 52841905

GI number: 52841905

Start: 1865410

End: 1866486

Strand: Reverse

Name: purM

Synonym: lpg1677

Alternate gene names: 52841905

Gene position: 1866486-1865410 (Counterclockwise)

Preceding gene: 52841906

Following gene: 52841904

Centisome position: 54.93

GC content: 39.93

Gene sequence:

>1077_bases
TTGGGAAAATGGCTTAAGAGAGAGGCTATTATAATGTCTACTATCAATTACAAATCAGCGGGTGTCGATATCGAGGCGGG
AAATGAAGCTGTCGCACGCATTAAACGTAATGTTGAAAAAACATTTTCGCCTCAAGTCCTGACAGGAATCGGTAGTTTTG
GCGCAATGTATGATTTGAAGCCTTTTATGGAAAAATTCAAACACCCCGTCATGGTTCAAAGCATTGATGGCGTAGGCACG
AAGACAATAGTTGCTCGGATGATGCAAAAATTTGATACAATCGGAATTGATTTGGTCAGTGCGACCACCAACGATATTAT
TGTGTTGGGTGCAAGGCCATTAACACTTTTGGACTATATAGCAACTGATCGATTGAAACCTGAATATATTGAAGAAATTA
TTATTGGCATGACGCAAGCTTGCCTCGAAAATAATATTTCCCTGGTCGGTGGTGAGACGGCTGAAATGCCTGATACCTAT
CTGAAGGGAGAGCATGATTTGGTAGGTATTATCACTGGTGTAGTGGAAAAGGATGAAGCCATACTAGGAAAAGATATAAC
TCCAGGCGATTCAGTCTTGGCATTTCCTTCCAGTGGCTTACATACCAATGGATATTCACTTGCCAGAAAACTTTTGTTTG
AACTAGGTGGATATACTGTAGAATCCCAACTTGACGAGTTGGATGCTACAGTTGGTGAGGCTTTACTGGTACCTCATATC
AATTATACAAATCCTGTTCTACACCTGTTGAATAACAAAATCCCTATCAAGGGAATGGCTCATATTACTGGCGGAGGTGT
ACTGGAAAACATTCCGCGAGTATTACCTAATCATTGTTCCGTTGAAATCAATAAGAATTCATGTCCGGTGTTGCCGATCT
TTAATGTGCTAAAAGCATTGGGGAAACTGGATGATCAGGAAATGTATCGTACTTTTAATATGGGAATAGGATTAGTAATG
ATAGCTTCCCCTGGTGTTGTTTCTGAAATTTATACAGCGCTAAAAGAATTCCCTAATTTCCCTGTTTATGAAGTAGGAAA
AGTCGTATCAGGAAAACCAGAAGTGAGATTATTGTGA

Upstream 100 bases:

>100_bases
AATATCAAGTCCCTTACATGGTTATCGGACATACTACAGAGCAGCCAGTTTTACAGATGAATTCGGTTATCAACTTGCCT
GTCGAAGAAGCGAGGCAGGC

Downstream 100 bases:

>100_bases
TGAAGATTGCAGTTGTTCAGTTTCCAGGCTCCAATTGCGAACGTGAGACAATGCTTGCGGTGCAACGAGCAGGTATGACT
CCAGTTGAGTTTCTGTGGAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MGKWLKREAIIMSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGT
KTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTY
LKGEHDLVGIITGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHI
NYTNPVLHLLNNKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVM
IASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL

Sequences:

>Translated_358_residues
MGKWLKREAIIMSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGT
KTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTY
LKGEHDLVGIITGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHI
NYTNPVLHLLNNKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVM
IASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL
>Mature_357_residues
GKWLKREAIIMSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLKPFMEKFKHPVMVQSIDGVGTK
TIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYIATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYL
KGEHDLVGIITGVVEKDEAILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHIN
YTNPVLHLLNNKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKALGKLDDQEMYRTFNMGIGLVMI
ASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=38.3954154727794, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=38.3954154727794, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=38.3954154727794, Blast_Score=237, Evalue=1e-62,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=42.9394812680115, Blast_Score=265, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=39.4202898550725, Blast_Score=209, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321203, Length=343, Percent_Identity=35.2769679300292, Blast_Score=205, Evalue=7e-54,
Organism=Drosophila melanogaster, GI24582400, Length=289, Percent_Identity=34.9480968858132, Blast_Score=173, Evalue=1e-43,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 39016; Mature: 38885

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKWLKREAIIMSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLK
CCCHHHHHHHEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
PFMEKFKHPVMVQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYI
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHH
ATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEA
HHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCH
ILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHI
HHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHCCEEEECCC
NYTNPVLHLLNNKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKAL
CCCCHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
GKLDDQEMYRTFNMGIGLVMIASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL
HCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
GKWLKREAIIMSTINYKSAGVDIEAGNEAVARIKRNVEKTFSPQVLTGIGSFGAMYDLK
CCHHHHHHHEEEECCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
PFMEKFKHPVMVQSIDGVGTKTIVARMMQKFDTIGIDLVSATTNDIIVLGARPLTLLDYI
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCCCEEEECCCHHHHHHHH
ATDRLKPEYIEEIIIGMTQACLENNISLVGGETAEMPDTYLKGEHDLVGIITGVVEKDEA
HHCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHCCCCCHHHHHHHHHHCCCH
ILGKDITPGDSVLAFPSSGLHTNGYSLARKLLFELGGYTVESQLDELDATVGEALLVPHI
HHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHHHHCCEEEECCC
NYTNPVLHLLNNKIPIKGMAHITGGGVLENIPRVLPNHCSVEINKNSCPVLPIFNVLKAL
CCCCHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHH
GKLDDQEMYRTFNMGIGLVMIASPGVVSEIYTALKEFPNFPVYEVGKVVSGKPEVRLL
HCCCHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA