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The map label for this gene is pbpC [H]

Identifier: 52841892

GI number: 52841892

Start: 1840733

End: 1843051

Strand: Reverse

Name: pbpC [H]

Synonym: lpg1664

Alternate gene names: 52841892

Gene position: 1843051-1840733 (Counterclockwise)

Preceding gene: 52841894

Following gene: 52841889

Centisome position: 54.24

GC content: 38.12

Gene sequence:

>2319_bases
CTGTTGTGGGCAATGAGAAAAGTAATAAAATATCTTAGCATAATCCTGGGTTCGCTATTTGTCAGTGGGTTTTTATTATT
ATTTTTTTCTCCCAAGCCTTCTTTATTAGAAGAATTCAATTTTTCTAAAGCGGTATATGATGATAATCAACAATTATTAA
GATTAATTTTAAGTGACGATGACAAATACAGACTTTATGTACCGTTATCTCAAATACCCAAGGAGTTAATGGAGGCCACA
CTTTTACAAGAAGATCAGTATTTTCTCTGGCATAAAGGAGTGAACCCTTTTTCCATGGTGAAAGCCATCTGGCAAACTTA
TGTGGTTAAATCGCGCAGAATCGGGGCTTCAACAATCACAATGCAGGTGGCACGAATTCGTTTTGGAATTAACTCCAAGA
AAATTTCTGGAAAATTATGGCAAGTTATTAGGGCGTTACAAATAGAGCGTCATTATGATAAAGATAAAATTCTTGAGGCT
TATTTCAATTTGGCGCCTTATGGTGGAAATATAGAGGGAGTAGGGGCGGCGAGCTTAATTTATTTTAATAAGCCTGTTAG
TAAACTTGGTTTACCAGAGGCACTAACTTTAAGCATTATCCCTCAAAATCCAGTAAAAAGGACATCAAAAAACAGTGAAT
TAAAAAAAATAAGAAATCGCTTATTTGCCAGATGGCTGAAGCAGCATCCGCAAGACCAGGAGAAGCAGCCTCTGTTTGGA
CTGCCTTTAGTTATGCAAACCAATCAAAACCTACCCTTCCTGGCTCCTCATTTTGTAAATATGGTACTGAAGGAAAATCC
TGGTTTATCACAAAGTATTTCAACAACTTTGGATTACAGGCTTCAGTTAATAGTTGAGCGAATTACAAGGCATTATTTAG
CAAGAAAAAAAATGTTTGGTGTTCACAACGCGGCGGTTTTACTTGTGGATAGCCGTACTATGAGTATTAAAGCGTTGATG
GGATCTGCTGATTTTTTTAATAACAAGATAAGTGGACAAATCAATGGTGTAGAAACCAAAAGGTCGCCTGGCTCAACTCT
GAAACCATTTATTTATGGATTAGCACTCGATCAAGGTTTAATTCACCCCAATACAGTTTTAAAGGATGTACCACAGAGTT
TTAATGGTTATAATCCGGAAAACTTCGATTATGATTTTATGGGGCCCATCAAAGCAAAAGATGCTTTGGTACTTAGTCGT
AATATCCCGGCCATCGAGCTTTCCAATCAATTAACTAATCCAACATTACATAAATTACTTGAACAGGCGCATATAACTCA
GTTGCGTTCTGAATCATATTATGGCTTGTCTCTTAATTTGGGTGGTGTTGAACTCACTATGAAAGAGTTAGTCGGTTTAT
ATGCTATGCTGATTAATGATGGGGTCTGGTATCCAATCAATTCATTAAAAGGGGTTCCGCGACAAAAAGGTCGACACTTG
CTTAGCGCAGAAGCAAGCTTTTTAGTTTTCGATATGCTAAAAAATACTCCAATGAAAGAGTCGAATAATGATGGCAGTTT
ACAATTACCAATTGCCTGGAAAACAGGAACTTCATCAGGATACAGAGATGCCTGGACAGTTGGAGTTTTTGGTCCTTATG
TATTGGCAGTTTGGATAGGAAATTTTGATAATCAGGCAAATCCGGCTTTTATAGGTAAAGAAATTGCTGCGCCTTTATTT
TTTGAATTGATTAATGCAATAAAACATGAAAGAGGACCAATAGCTCGAGTTGAAAAATACCCTGAACACATGCATTTGGA
AAAAATAGAAGTATGCAAAGCCTCAGGTATGCTTCCTGGTCGATATTGTACGGATACAGAATGGACCTGGTTTATTCCAG
GTAAATCCCCTATTAAAACGGATACAATTTTTCGAGAGGTAGCAATTAACGGGAAGACGGGGCTTCGTACTTGTCACATC
GATGAAAATACTCGTTTTGAAGTGTATGAGTTTTGGCCCTCCGATTTATTAAGAATATTCAGGAGGGCAGGGATTCAACG
CCATACCCCGCCATTTTTTGAACCAGGTTGCGCTTTGTCGGGAAATAGTGGTATTAGCCCCCAAATTACATCTCCCCAGG
CAGGGGTAAGTTATATTGTCCATGCTAATACCCAATCAAACAAGATAATCCCATTAACTGCGGTAACAGATGCTGGAATT
GCACATTTATACTGGTTTATCAATGAAAGTTTTGTAGCTGAAACAAAATCGGATGAACCTTATCTCTGGCAGGCGAAACC
TGGTAAATATGTGGTAAGGGTGGTAGATGACCGTGGTTTATCTGATGCGCGGGATATTACTATTCAGATGGTTAGTTGA

Upstream 100 bases:

>100_bases
ATACACCCCCCGCAATAAATTATTAATTATTAGTCTATCCTTTGCCAATTCTAATGCATTTCAATATTAATTTGAATATA
ATTTAACCTTTATATCATCC

Downstream 100 bases:

>100_bases
CGCATATTTGATAATATATAAGTGAGCCCTTGTCCTAATCGGAGCAAGGGATTTAAAATTAAACTGAGGCCGAGTTTCTT
GACTCTTCATCTTCGTTCTC

Product: penicillin binding protein 1C, peptidoglycan biosynthesis

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 772; Mature: 772

Protein sequence:

>772_residues
MLWAMRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSDDDKYRLYVPLSQIPKELMEAT
LLQEDQYFLWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQVIRALQIERHYDKDKILEA
YFNLAPYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFG
LPLVMQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALM
GSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSR
NIPAIELSNQLTNPTLHKLLEQAHITQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRHL
LSAEASFLVFDMLKNTPMKESNNDGSLQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLF
FELINAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHI
DENTRFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGI
AHLYWFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDITIQMVS

Sequences:

>Translated_772_residues
MLWAMRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSDDDKYRLYVPLSQIPKELMEAT
LLQEDQYFLWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQVIRALQIERHYDKDKILEA
YFNLAPYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFG
LPLVMQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALM
GSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSR
NIPAIELSNQLTNPTLHKLLEQAHITQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRHL
LSAEASFLVFDMLKNTPMKESNNDGSLQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLF
FELINAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHI
DENTRFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGI
AHLYWFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDITIQMVS
>Mature_772_residues
MLWAMRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSDDDKYRLYVPLSQIPKELMEAT
LLQEDQYFLWHKGVNPFSMVKAIWQTYVVKSRRIGASTITMQVARIRFGINSKKISGKLWQVIRALQIERHYDKDKILEA
YFNLAPYGGNIEGVGAASLIYFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFG
LPLVMQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFGVHNAAVLLVDSRTMSIKALM
GSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGLIHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSR
NIPAIELSNQLTNPTLHKLLEQAHITQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRHL
LSAEASFLVFDMLKNTPMKESNNDGSLQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIGNFDNQANPAFIGKEIAAPLF
FELINAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPGRYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHI
DENTRFEVYEFWPSDLLRIFRRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGI
AHLYWFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDITIQMVS

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=750, Percent_Identity=30.4, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI1786343, Length=535, Percent_Identity=26.1682242990654, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI87082258, Length=218, Percent_Identity=32.5688073394495, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789601, Length=204, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 87324; Mature: 87324

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWAMRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSDD
CHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHCCCCHHEECCCHHHHHHHHCCC
DKYRLYVPLSQIPKELMEATLLQEDQYFLWHKGVNPFSMVKAIWQTYVVKSRRIGASTIT
CCEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHH
MQVARIRFGINSKKISGKLWQVIRALQIERHYDKDKILEAYFNLAPYGGNIEGVGAASLI
HEEEHHHCCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
YFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFG
EECCCHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPLVMQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFG
CCEEEECCCCCCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VHNAAVLLVDSRTMSIKALMGSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGL
CCCEEEEEEECCCEEEEEECCCHHHHCCCCCCEEECEECCCCCCCCHHHHHHHHHHCCCC
IHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPAIELSNQLTNPTLHKLL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHH
EQAHITQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRHL
HHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCHHHCCEE
LSAEASFLVFDMLKNTPMKESNNDGSLQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIG
HHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEHHHHHEEEEEEEC
NFDNQANPAFIGKEIAAPLFFELINAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCHHHHHHHHHCCCCCC
RYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENTRFEVYEFWPSDLLRIF
CEECCCCEEEEECCCCCCCHHHHHHHHEECCCCCCEEEEECCCCCEEEEEECHHHHHHHH
RRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCH
AHLYWFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDITIQMVS
HHHHHHHCCHHEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MLWAMRKVIKYLSIILGSLFVSGFLLLFFSPKPSLLEEFNFSKAVYDDNQQLLRLILSDD
CHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHCCCCHHEECCCHHHHHHHHCCC
DKYRLYVPLSQIPKELMEATLLQEDQYFLWHKGVNPFSMVKAIWQTYVVKSRRIGASTIT
CCEEEEEEHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHH
MQVARIRFGINSKKISGKLWQVIRALQIERHYDKDKILEAYFNLAPYGGNIEGVGAASLI
HEEEHHHCCCCCHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCEEEE
YFNKPVSKLGLPEALTLSIIPQNPVKRTSKNSELKKIRNRLFARWLKQHPQDQEKQPLFG
EECCCHHHHCCCCEEEEEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
LPLVMQTNQNLPFLAPHFVNMVLKENPGLSQSISTTLDYRLQLIVERITRHYLARKKMFG
CCEEEECCCCCCEECHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VHNAAVLLVDSRTMSIKALMGSADFFNNKISGQINGVETKRSPGSTLKPFIYGLALDQGL
CCCEEEEEEECCCEEEEEECCCHHHHCCCCCCEEECEECCCCCCCCHHHHHHHHHHCCCC
IHPNTVLKDVPQSFNGYNPENFDYDFMGPIKAKDALVLSRNIPAIELSNQLTNPTLHKLL
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCCHHHHHHH
EQAHITQLRSESYYGLSLNLGGVELTMKELVGLYAMLINDGVWYPINSLKGVPRQKGRHL
HHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCHHHCCEE
LSAEASFLVFDMLKNTPMKESNNDGSLQLPIAWKTGTSSGYRDAWTVGVFGPYVLAVWIG
HHCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCEEEEHHHHHEEEEEEEC
NFDNQANPAFIGKEIAAPLFFELINAIKHERGPIARVEKYPEHMHLEKIEVCKASGMLPG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCHHHHCHHHHHHHHHCCCCCC
RYCTDTEWTWFIPGKSPIKTDTIFREVAINGKTGLRTCHIDENTRFEVYEFWPSDLLRIF
CEECCCCEEEEECCCCCCCHHHHHHHHEECCCCCCEEEEECCCCCEEEEEECHHHHHHHH
RRAGIQRHTPPFFEPGCALSGNSGISPQITSPQAGVSYIVHANTQSNKIIPLTAVTDAGI
HHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCH
AHLYWFINESFVAETKSDEPYLWQAKPGKYVVRVVDDRGLSDARDITIQMVS
HHHHHHHCCHHEECCCCCCCEEEECCCCCEEEEEECCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]