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The map label for this gene is proA

Identifier: 52841837

GI number: 52841837

Start: 1775391

End: 1776644

Strand: Reverse

Name: proA

Synonym: lpg1609

Alternate gene names: 52841837

Gene position: 1776644-1775391 (Counterclockwise)

Preceding gene: 52841838

Following gene: 52841833

Centisome position: 52.29

GC content: 34.05

Gene sequence:

>1254_bases
ATGAATACTAATATTGCTAACCAATTAAGGGCCGCTAAAAAAGCAACTACTGATCTTAACTTAATACAAAGTGATACCCG
AACAATAATTTTGAAAACATTAGCGGCTAATTTAGAGAAGCACATTGAAAACATAATACAAGAAAATCAAAAAGATTTAA
GTTTAATGCTTGAGCAAGATCCCAGATATGATCGTTTATTGTTAAATAAAGAGAGAATTTTGTCATTGGTGAATGATGTG
AGAAAAGTAGCCAATTTACCTAACCCATTAGGAGTTAATCTCTTTGAAAAATCAATGCCAAATGGTTTGAGTATTAAGAA
AATCACAGTACCTTTAGGTGTCATCGCAGTCATTTATGAGTCAAGACCTAATGTAACTATTGATATATTCAGCCTATGCT
TTAAATCTGGAAACGTTTGTATTTTAAAAGGTGGAAAAGAAGCACATTTTACTAACAGTTATCTGCTTTTATTAATTAAA
AATACATTAAAGAATTTTAATATAAACACAGATATTGTTTGTTTATTACCACCAGAAAGAGCATTGATGACTCAATTATT
AAATGCCACAGGTCTTGTTGATTTATGCATTCCAAGAGGGAGCCAGAATTTAATAAATTTTGTCAGAGACAATGCCAAAA
TACCTGTCATTGAAACAGGGGCAGGTATCGTGCATACCTATTTTGATAAAAGTGGAGATTTGGGAAAAGGTAAAAAAATT
ATTAACAATGCTAAAACCAGAAGAGTAAGTGTTTGCAATGCGCTGGATACTTTGATTATTCATGCTGATCGTTTAAAAGA
TTTGCCAGAACTTGTGGAGACCTTGTCTCAAAAGAATGTGATTATCTATGCCGACCAGGATGCATATCATGTTTTAGATA
AGAATTATCCTGAACAACTTTTAATTAAGGCAAAACCACAAGACTTTGGCCATGAATTTCTAGACTATAAATTAGCAATA
AAAACAGTACCCAATATAAAAGCAGCTATTGATCATATTCAACAATTCAGTTCCCATCATAGTGAGGCTGTTATTGCAGA
AGATGAGTCTGCAATTGATAAATTTCTAACTGAAGTGGATGCAGCAGCTGTCTATGCCAACGCTTCTACTGCGTTTACAG
ATGGCGGGGAATTCGGATTAGGGGCTGAAATTGGAATTAGTACGCAAAAAGTTCATGCAAGAGGACCCATGGGACTAGAG
GCTTTAACAAGCTACAAATGGGTGATAAGAGGGACGGGACAAATTAGAGATTGA

Upstream 100 bases:

>100_bases
TCGCCAGGTATGATTTCTTAAGATTAAAGGACTATCTTAGACTTCAAAATAAGCCTGCATTTATACATTACGATCAATTG
CATATTCTATAGGTATCAAA

Downstream 100 bases:

>100_bases
GCATAACCATATTTTCTCAGCACCCCACCCAACAATGACAACTGCAATAATCACCACTTTTCTGATATTGGATTGTTATC
AAAATATTCACCGAGTCTGC

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MNTNIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLVNDV
RKVANLPNPLGVNLFEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD

Sequences:

>Translated_417_residues
MNTNIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLVNDV
RKVANLPNPLGVNLFEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD
>Mature_417_residues
MNTNIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQDPRYDRLLLNKERILSLVNDV
RKVANLPNPLGVNLFEKSMPNGLSIKKITVPLGVIAVIYESRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIK
NTLKNFNINTDIVCLLPPERALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYHVLDKNYPEQLLIKAKPQDFGHEFLDYKLAI
KTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVDAAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLE
ALTSYKWVIRGTGQIRD

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=418, Percent_Identity=34.2105263157895, Blast_Score=232, Evalue=5e-61,
Organism=Homo sapiens, GI62912457, Length=418, Percent_Identity=34.2105263157895, Blast_Score=232, Evalue=5e-61,
Organism=Escherichia coli, GI1786438, Length=413, Percent_Identity=40.4358353510896, Blast_Score=304, Evalue=7e-84,
Organism=Caenorhabditis elegans, GI17569969, Length=411, Percent_Identity=33.5766423357664, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17569967, Length=411, Percent_Identity=33.5766423357664, Blast_Score=222, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324899, Length=424, Percent_Identity=36.7924528301887, Blast_Score=253, Evalue=5e-68,
Organism=Drosophila melanogaster, GI21357643, Length=407, Percent_Identity=33.1695331695332, Blast_Score=226, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: NA

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 46174; Mature: 46174

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLVNDVRKVANLPNPLGVNLFEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYHVLDKNYPEQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCCCCCE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
HHHEEECCCCEECCCCCCCCCCEECCCCCEEECCCCCCHHHHHCEEEEEECCCCCCC
>Mature Secondary Structure
MNTNIANQLRAAKKATTDLNLIQSDTRTIILKTLAANLEKHIENIIQENQKDLSLMLEQD
CCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCC
PRYDRLLLNKERILSLVNDVRKVANLPNPLGVNLFEKSMPNGLSIKKITVPLGVIAVIYE
CCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEEEECCEEEEEEEE
SRPNVTIDIFSLCFKSGNVCILKGGKEAHFTNSYLLLLIKNTLKNFNINTDIVCLLPPER
CCCCEEEEHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCCEEEEECCCH
ALMTQLLNATGLVDLCIPRGSQNLINFVRDNAKIPVIETGAGIVHTYFDKSGDLGKGKKI
HHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCCCCHHH
INNAKTRRVSVCNALDTLIIHADRLKDLPELVETLSQKNVIIYADQDAYHVLDKNYPEQL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHCCCCCCCE
LIKAKPQDFGHEFLDYKLAIKTVPNIKAAIDHIQQFSSHHSEAVIAEDESAIDKFLTEVD
EEEECCHHHCHHHHHEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
AAAVYANASTAFTDGGEFGLGAEIGISTQKVHARGPMGLEALTSYKWVIRGTGQIRD
HHHEEECCCCEECCCCCCCCCCEECCCCCEEECCCCCCHHHHHCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA