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The map label for this gene is pdhA [H]

Identifier: 52841788

GI number: 52841788

Start: 1721538

End: 1722632

Strand: Direct

Name: pdhA [H]

Synonym: lpg1558

Alternate gene names: 52841788

Gene position: 1721538-1722632 (Clockwise)

Preceding gene: 52841784

Following gene: 52841789

Centisome position: 50.67

GC content: 40.82

Gene sequence:

>1095_bases
TTGTTGACAAGGAGCCATGTAATGACAACTGTTGCTCAATTTGAAATAACATACACACAATACCTGAATGAACAAGGTAA
GTTGGTCGCTGAATTACCTCCATTCGCAGATAATCAATCCATACTTAAAGAATTGTATAAAATCATGGTACTCACCCGTA
CTTTTGATAAAAAAGCAATTGCATTACAAAGAACAGGGAAAATGGGAACCTATGCGCCAATTAATGGCCAGGAAGCTATT
TCGACTGCAATTGGGCATGCTCTTAAACCTGAAGATGTACTTGTACCTTATTACAGAGATTATGCCGCTCAATTTCAGAG
AGGCGTTAAAATGTCAGAGATACTCGCCTTTTGGGGAGGGGATGAGCGAGGAAGTCATTATTCTAATAATGCCGAAGATT
TGCCTATTTGTGTCCCAATTGCATCTCAATGTTTGCATGCCGCAGGAGTCGCATTTGCCTTCAAATACAGAAACCAACCA
AGAGTAGCTGTGGTATGTATTGGAGAAGGAGGCACTTCAGAAGGTGATTTTTACGAAGCCATGAATGTGGCTGGGGCATG
GAAATTACCAGTGGTCTTCGTAGTAAATAATAACAAATGGGCGATTTCTGTGCCTATAGAGAAACAAACTGGCTCACAAA
CAATAGCCCAAAAAGCGATTGCTGCTGGTTTTTCTGGCGTTCAAATAGACGGTAATGATATTTTTGCTGCAAGACAGGTT
ATAGGGGATGCTATTGAAAAGGCTCGTCAAGGTGGTGGACCTACTCTAATCGAAGCCTTAACCTATCGCTTGTGCGACCA
TACAACGGCTGATGATGCAACACGCTATCAGCCTTCTCATGAAGTAGAGGAGGCAAAAGCCAAAGAGCCTATTGTTCGTT
TTAAACACTATTTAATGCAACAAAATATTTGGACATCTCAGGATGAAGAAAAGCTGGTTATAGAATGCAGTGAAACGGTG
GAAAAAGCAGTAGAGGAATATTTGAATACCAAACCTCAGCCTGTTAGCAGCATTTTTGATTATCATTACGCAGAATTACC
AGAATATTTAATTGAACAACGCGCAATAGCCATGGAGGAGTATTCTCATGCCTGA

Upstream 100 bases:

>100_bases
TTTTAACCTAACTTATCAATAAAAAACGTATATTTTTATCTTGGGTTCCTATTAATTTACTGGTTTTTAAATTAATTTGT
GAGTATCCTATGCCAACGCG

Downstream 100 bases:

>100_bases
TATTACTTTAGTTGAAGCTGTTACTCAGGCTTTGGCGTATGAGTTAGCTCATGATGAAAATGTAGTAGTCTTTGGCGAAG
ATGTTGGTAAAAATGGTGGA

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MLTRSHVMTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAI
STAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYRNQP
RVAVVCIGEGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQV
IGDAIEKARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEEAKAKEPIVRFKHYLMQQNIWTSQDEEKLVIECSETV
EKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA

Sequences:

>Translated_364_residues
MLTRSHVMTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAI
STAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYRNQP
RVAVVCIGEGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQV
IGDAIEKARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEEAKAKEPIVRFKHYLMQQNIWTSQDEEKLVIECSETV
EKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA
>Mature_364_residues
MLTRSHVMTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAIALQRTGKMGTYAPINGQEAI
STAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGGDERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYRNQP
RVAVVCIGEGGTSEGDFYEAMNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQV
IGDAIEKARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEEAKAKEPIVRFKHYLMQQNIWTSQDEEKLVIECSETV
EKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEEYSHA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=345, Percent_Identity=31.304347826087, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI258645172, Length=345, Percent_Identity=31.304347826087, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI4505685, Length=330, Percent_Identity=25.4545454545455, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI291084742, Length=330, Percent_Identity=25.4545454545455, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI291084744, Length=298, Percent_Identity=25.8389261744966, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4885543, Length=353, Percent_Identity=24.929178470255, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI291084757, Length=309, Percent_Identity=24.2718446601942, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86563355, Length=335, Percent_Identity=33.134328358209, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI86563357, Length=335, Percent_Identity=33.134328358209, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32564172, Length=318, Percent_Identity=26.7295597484277, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17536047, Length=318, Percent_Identity=26.7295597484277, Blast_Score=121, Evalue=7e-28,
Organism=Saccharomyces cerevisiae, GI6321026, Length=306, Percent_Identity=26.797385620915, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21355903, Length=348, Percent_Identity=30.4597701149425, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24639744, Length=264, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28571106, Length=264, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639740, Length=264, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24639746, Length=264, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24639748, Length=284, Percent_Identity=27.112676056338, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40587; Mature: 40587

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTRSHVMTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAI
CCCHHHHHHHHHHHEEHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHH
ALQRTGKMGTYAPINGQEAISTAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGG
HHECCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCCHHHHHHHCCC
DERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYRNQPRVAVVCIGEGGTSEGDFYEA
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHH
MNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQV
HHCCCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHH
IGDAIEKARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEEAKAKEPIVRFKHYLMQ
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QNIWTSQDEEKLVIECSETVEKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEE
CCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSHA
HCCC
>Mature Secondary Structure
MLTRSHVMTTVAQFEITYTQYLNEQGKLVAELPPFADNQSILKELYKIMVLTRTFDKKAI
CCCHHHHHHHHHHHEEHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCHHH
ALQRTGKMGTYAPINGQEAISTAIGHALKPEDVLVPYYRDYAAQFQRGVKMSEILAFWGG
HHECCCCCCCCCCCCCHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHCCCHHHHHHHCCC
DERGSHYSNNAEDLPICVPIASQCLHAAGVAFAFKYRNQPRVAVVCIGEGGTSEGDFYEA
CCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHEEEEECCCCCEEEEEECCCCCCCCHHHHH
MNVAGAWKLPVVFVVNNNKWAISVPIEKQTGSQTIAQKAIAAGFSGVQIDGNDIFAARQV
HHCCCCCCCCEEEEEECCEEEEEECCCCCCCHHHHHHHHHHCCCCCEEECCCHHHHHHHH
IGDAIEKARQGGGPTLIEALTYRLCDHTTADDATRYQPSHEVEEAKAKEPIVRFKHYLMQ
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
QNIWTSQDEEKLVIECSETVEKAVEEYLNTKPQPVSSIFDYHYAELPEYLIEQRAIAMEE
CCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSHA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA