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The map label for this gene is vdlC [H]

Identifier: 52841730

GI number: 52841730

Start: 1658523

End: 1659224

Strand: Reverse

Name: vdlC [H]

Synonym: lpg1500

Alternate gene names: 52841730

Gene position: 1659224-1658523 (Counterclockwise)

Preceding gene: 52841731

Following gene: 52841729

Centisome position: 48.83

GC content: 35.47

Gene sequence:

>702_bases
TTGCAAAAAGTTAAAAGATCAATTATTTTGATTTTACAAGCCACGGATAGAGGATTTAAATTGAAGACTCTCGTCATAAC
AGGAATCAGTAGAGGTATAGGCCTGGAAATTGCTAGAATTTTCCTTGACAAAGATTGGACGGTTATTGGTACTTCCACCA
GCGGATATTCTCCTATAAAACATAAAAACCTACGCACATACAAGTTAGACCTAGCCATTTCGGAGCACATCGATGCATTT
GCAAAAAATTTACCTAAAATTGATGTACTGATTAATAATGCCGCCGTGTTGCTTGAAGAGTGGAATGAAGAAAAAATTAA
TATGTCCTTATTGAAAAAAACCTTTGCAATTAACCTGTTTGGTACAGTTGAGTTAACTGAAAAATGTATCCCCAAGTTCA
ATGATAGTGCACAAATTATTAATATCTCTTCAGGGTGGGGAGCATTTAGTTCCAATAATTCCCCCTTTCAACCACATTAT
AAAATGTCAAAAGTCAGTTTGAATATGTATACTAAATTGCTTGCGGAAAGACTTCCCCAAATAACTGTATCCAGTTTTGA
TCCAGGTTGGGTTAAAACAAACATGGGAACACAAAATGCAAAAAAACTTCCCAGTGAAACGGCACTGGAAATCTATGAGC
TGATTAGTATGAAGAAAAAAAGCGGCTATTTTTGGTTTAATGGAAAACCAAGGGATTGGTAG

Upstream 100 bases:

>100_bases
AGAAAAATCTCAAGATCCAGGTAAAAAATGTTTTTTAGGAGGGAATTTAGATAAACCAAATGATTGAATTATAAAATTTT
TTTAACTAAGAGATTGAGTT

Downstream 100 bases:

>100_bases
CCAGTTAAATTTCAGTTATTCTCAACTATAAAATAAAGCATCAAAGGAGTGACAAACGTGAGTTTCGATTTTATAAAATC
AATATGGATTGCAGCTCTTA

Product: oxidoreductase, short chain dehydrogenase/reductase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MQKVKRSIILILQATDRGFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDSAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Sequences:

>Translated_233_residues
MQKVKRSIILILQATDRGFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDSAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
>Mature_233_residues
MQKVKRSIILILQATDRGFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIKHKNLRTYKLDLAISEHIDAF
AKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLFGTVELTEKCIPKFNDSAQIINISSGWGAFSSNNSPFQPHY
KMSKVSLNMYTKLLAERLPQITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17558994, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17559962, Length=212, Percent_Identity=31.1320754716981, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558990, Length=211, Percent_Identity=27.4881516587678, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI72001658, Length=211, Percent_Identity=29.3838862559242, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559964, Length=210, Percent_Identity=31.4285714285714, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI193207563, Length=243, Percent_Identity=25.5144032921811, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17558992, Length=246, Percent_Identity=27.2357723577236, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=233, Percent_Identity=27.0386266094421, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=236, Percent_Identity=27.9661016949153, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=238, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17532177, Length=213, Percent_Identity=30.9859154929577, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558996, Length=240, Percent_Identity=27.5, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=238, Percent_Identity=30.672268907563, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322226, Length=195, Percent_Identity=29.7435897435897, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24640547, Length=251, Percent_Identity=28.6852589641434, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26407; Mature: 26407

Theoretical pI: Translated: 10.25; Mature: 10.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKVKRSIILILQATDRGFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIK
CCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCC
HKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLF
CCCCEEEEEEEEHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEE
GTVELTEKCIPKFNDSAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAERLPQ
EEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCC
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
EEEECCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure
MQKVKRSIILILQATDRGFKLKTLVITGISRGIGLEIARIFLDKDWTVIGTSTSGYSPIK
CCCCCEEEEEEEEECCCCEEEEEEEEEECCCCCCCEEEEEEECCCCEEEECCCCCCCCCC
HKNLRTYKLDLAISEHIDAFAKNLPKIDVLINNAAVLLEEWNEEKINMSLLKKTFAINLF
CCCCEEEEEEEEHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHEEEEE
GTVELTEKCIPKFNDSAQIINISSGWGAFSSNNSPFQPHYKMSKVSLNMYTKLLAERLPQ
EEEEHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCC
ITVSSFDPGWVKTNMGTQNAKKLPSETALEIYELISMKKKSGYFWFNGKPRDW
EEEECCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9139899; 9252185 [H]