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The map label for this gene is mutH

Identifier: 52841710

GI number: 52841710

Start: 1635309

End: 1635980

Strand: Direct

Name: mutH

Synonym: lpg1480

Alternate gene names: 52841710

Gene position: 1635309-1635980 (Clockwise)

Preceding gene: 52841709

Following gene: 52841713

Centisome position: 48.13

GC content: 38.69

Gene sequence:

>672_bases
GTGTTAGCCTTAAAAAACAAACCACCGAAGAATGAAAAAGAACTTTTGGAGCAATGCCAGCGAATTGAGGGGTTGAGTTT
CGCTCAGTTAGCTCTTGAATTGGGTCTATTTACCCCTGTAAACCCTGTTCATCGAAAAGGATGGGTTGGGCAAGCTCTCG
AGTTAGCTTTAGGTGCTGATGCAAAAAATGAGTCGCTACCTGATTTTAAGCAGTTGGGCATTGAATTAAAAACGATACCT
ATTAATAAATCAGGGAAACCAGCCGAGTCCACATTTATTGTTTCTATTCCACTACTGACCATCCATCAGCAAAGTTGGGA
GTCTTCTCAATGTTACGCTAAACTCAAAAAAGTATTATGGATTCCTATAGAGGGAGATACAGATATTCCCTTTCCTCACA
GAAGAATTGGATGTGGATTTTTATGGTCTCCGAATAAAGATCAGGAATCTGTTCTTGCAGAAGATTGGAATTATTTAACA
AATCAAATAGTTCTGGGACAATTAGAAACATTAAATTCCTTTTCGGGAGAGTATCTTCAAGTGAGGCCTAAGGCTGCCAA
TGGAAAATCTTTATGTTATGGTTATGACCCAGAGGGTAATCGTATAAGAACGTTACCACGAGGATTTTATTTACGCGCCT
GTTTTACATCCGTAATTTTAAGTCAATCCTAA

Upstream 100 bases:

>100_bases
GTAAGGTCAAAAGTCTTGTTTGCCATAACTGCACAGTTTAAAGCGGCAGGAATACAGCCGCCAATTGAGCCTATTACTGT
TGAACTAAAAGAGAGCTCCA

Downstream 100 bases:

>100_bases
TTTTAAGGATAAATTAAGCACCATCTGTTTACCGGTATTATGATAAATTTTACAGATATTAGGGAAAGCTCATTATAGCT
TTTGTCTATTAGTATACATG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MLALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKQLGIELKTIP
INKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLT
NQIVLGQLETLNSFSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRACFTSVILSQS

Sequences:

>Translated_223_residues
MLALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKQLGIELKTIP
INKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLT
NQIVLGQLETLNSFSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRACFTSVILSQS
>Mature_223_residues
MLALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGADAKNESLPDFKQLGIELKTIP
INKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLWIPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLT
NQIVLGQLETLNSFSGEYLQVRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRACFTSVILSQS

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=215, Percent_Identity=48.3720930232558, Blast_Score=218, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25028; Mature: 25028

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGAD
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHCCC
AKNESLPDFKQLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLW
CCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHEEE
IPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLTNQIVLGQLETLNSFSGEYLQ
EECCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRACFTSVILSQS
EECCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLALKNKPPKNEKELLEQCQRIEGLSFAQLALELGLFTPVNPVHRKGWVGQALELALGAD
CCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHCCC
AKNESLPDFKQLGIELKTIPINKSGKPAESTFIVSIPLLTIHQQSWESSQCYAKLKKVLW
CCCCCCCCHHHCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHHHEEE
IPIEGDTDIPFPHRRIGCGFLWSPNKDQESVLAEDWNYLTNQIVLGQLETLNSFSGEYLQ
EECCCCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
VRPKAANGKSLCYGYDPEGNRIRTLPRGFYLRACFTSVILSQS
EECCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA