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The map label for this gene is bioA

Identifier: 52841701

GI number: 52841701

Start: 1624710

End: 1626092

Strand: Reverse

Name: bioA

Synonym: lpg1471

Alternate gene names: 52841701

Gene position: 1626092-1624710 (Counterclockwise)

Preceding gene: 52841711

Following gene: 52841699

Centisome position: 47.86

GC content: 38.54

Gene sequence:

>1383_bases
GTGAACATGATAAAGTCGCTCCTATACTTGTCAACCAAAATTTTTAAAATGGTAAACACAGATCAACTTATTGCAAAAGA
CTTAAAGCACATTTGGCATCCTTGTTCACAAATGAAAGATTTCGAAACATTCCCCCCTATCGTTGTCAACAAAGCACAAG
GCAGCTATCTCTATACCAATAAGGGCCCCGTGATTGATGCAATTTCCAGTTGGTGGTGCAAATCATTAGGGCATGGTCAT
CCAGCAGTGATAGCTGCTATCAAGAACCAACTGGACTGCTTTGAGCATGTGATTAGTGCCAATACAACTCATCCTGCTGC
AGTGGAATTAGCTGAAAAATTAAGCGAAATTACAGGAAAACAGCATGTGTTTTTTGCTAGTGATGGTTCCAGTGCTGTTG
AAATTGCCATGAAATTAGCTATTCATGCTTCACAAATAAAAGGGCACAAAAATAAAAACCAATTCATTGCCTTAAAAAAT
GGCTACCACGGAGAAACTATTGGCACCATGAGTGTCAGTGATTTGGGACTCTATAAGACTCCCTATGCATCGTTTGGCGT
GCAATGCCATTACATCGATGATATTCCCTATGTCTCAGGCCTTAAGGATCCCTTATGGACAAATTGCGATGCTTATTGGA
ATAAAGTCGTACAACAATTGAATAAAATTTGCGATAAAGTTTGCGCGATACTTCTGGAGCCTATCATTCAGGGTGCTGGA
GGTATGCTATGTTACAGTGCAGATTTTCTCTCAAAAATCTCGTCATGGGCTAAGGAAAAAGACATTTATTTAATTGCTGA
TGAGATTATGACTGGTATAGGCAGAACTGGAGAATGGCTAGCCTGTGATCATGCAAGGATACAACCTGATCTGATTTGTC
TATCCAAAGGATTAACTTCCGGCTCAATACCATTTAGCTGTGTCATGATTGACAGTACCTTATTTGATCTTTTTTATGAT
GATTACCATACAGGGAAATCTTTTTTGCACTCACATACCTATAGCGGTAATCCACTTGCTATAGTCGCTGCTTTAGCAAC
TATTAAAACAATAGAACAAGATAATTTACTCATGCATAGTCAGGAACTTGGTAAAATCATGTTTTCCTATCTGCAGGATA
TAGCAAGGGACAGTAGAAAACTTGTAAATGTTCGTGGTGTTGGAGCAGTTGTTGCGGCTGATTTCATAGAGAGCAGTCAA
GCAAGAATTGGGTTTAAAATTTATCAGGAAGCAATAAAACAAGGCGCACTGATTCGCCCAATTGGAAATACTCTCTATTG
GTTACCACCTCTTAACACAGATAAAGAAATCATTGGGAAATTAGCAGAAATCACATTAAACTCTATAGAAAAAGCCTATA
ACAAAGCTCAAGGATATGAGTAA

Upstream 100 bases:

>100_bases
AAAGCAAATCATTAAATGGTTGTTGATAAATTGCTTCAATATCAGAAATTGACCACTGTTTTTTTTCTTCAGACACGGCT
ACCCCCTTTAATTCAGAATA

Downstream 100 bases:

>100_bases
GGTTATTCACAAATAGTTTAAAGACAAATCGGTTCGCCAATTGTTAAAAGAACAGCAATCTCCTTGACCCAAAACCAAGT
GATTTGCCTAAAACCTGCTA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MNMIKSLLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGH
PAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKN
GYHGETIGTMSVSDLGLYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNKVVQQLNKICDKVCAILLEPIIQGAG
GMLCYSADFLSKISSWAKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYD
DYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADFIESSQ
ARIGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE

Sequences:

>Translated_460_residues
MNMIKSLLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGH
PAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKN
GYHGETIGTMSVSDLGLYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNKVVQQLNKICDKVCAILLEPIIQGAG
GMLCYSADFLSKISSWAKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYD
DYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADFIESSQ
ARIGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE
>Mature_460_residues
MNMIKSLLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTNKGPVIDAISSWWCKSLGHGH
PAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGKQHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKN
GYHGETIGTMSVSDLGLYKTPYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNKVVQQLNKICDKVCAILLEPIIQGAG
GMLCYSADFLSKISSWAKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTSGSIPFSCVMIDSTLFDLFYD
DYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHSQELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADFIESSQ
ARIGFKIYQEAIKQGALIRPIGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=437, Percent_Identity=27.6887871853547, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI13994255, Length=378, Percent_Identity=25.9259259259259, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=29.1925465838509, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI24119277, Length=439, Percent_Identity=25.7403189066059, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI37574042, Length=387, Percent_Identity=24.031007751938, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI226442709, Length=339, Percent_Identity=23.3038348082596, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI226442705, Length=387, Percent_Identity=23.2558139534884, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI1786991, Length=425, Percent_Identity=34.3529411764706, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI145693181, Length=373, Percent_Identity=30.8310991957105, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1787560, Length=382, Percent_Identity=30.6282722513089, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1789759, Length=381, Percent_Identity=28.6089238845144, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788044, Length=399, Percent_Identity=28.5714285714286, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=27.8571428571429, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=408, Percent_Identity=25.4901960784314, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=27.2108843537415, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71992977, Length=392, Percent_Identity=26.7857142857143, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=319, Percent_Identity=26.3322884012539, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17541228, Length=394, Percent_Identity=22.8426395939086, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=484, Percent_Identity=29.5454545454545, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=411, Percent_Identity=29.4403892944039, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=420, Percent_Identity=25.4761904761905, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=24.8157248157248, Blast_Score=125, Evalue=8e-29,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=26.0180995475113, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574759, Length=420, Percent_Identity=25.952380952381, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI21356575, Length=418, Percent_Identity=24.4019138755981, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI281366494, Length=382, Percent_Identity=22.7748691099476, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667139, Length=382, Percent_Identity=22.7748691099476, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24667143, Length=382, Percent_Identity=22.7748691099476, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 50996; Mature: 50996

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMIKSLLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTN
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEC
KGPVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGK
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
QHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKT
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEECCCCCCCCC
PYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNKVVQQLNKICDKVCAILLEPIIQGAG
CCHHHCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GMLCYSADFLSKISSWAKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTS
CEEEECHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCC
GSIPFSCVMIDSTLFDLFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHS
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADFIESSQARIGFKIYQEAIKQGALIRP
HHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEE
IGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNMIKSLLYLSTKIFKMVNTDQLIAKDLKHIWHPCSQMKDFETFPPIVVNKAQGSYLYTN
CHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEC
KGPVIDAISSWWCKSLGHGHPAVIAAIKNQLDCFEHVISANTTHPAAVELAEKLSEITGK
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
QHVFFASDGSSAVEIAMKLAIHASQIKGHKNKNQFIALKNGYHGETIGTMSVSDLGLYKT
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEECEECCCCCCCCC
PYASFGVQCHYIDDIPYVSGLKDPLWTNCDAYWNKVVQQLNKICDKVCAILLEPIIQGAG
CCHHHCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GMLCYSADFLSKISSWAKEKDIYLIADEIMTGIGRTGEWLACDHARIQPDLICLSKGLTS
CEEEECHHHHHHHHHHHHHCCEEEEHHHHHHHCCCCCCEEEECCCCCCCHHHHHHCCCCC
GSIPFSCVMIDSTLFDLFYDDYHTGKSFLHSHTYSGNPLAIVAALATIKTIEQDNLLMHS
CCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHH
QELGKIMFSYLQDIARDSRKLVNVRGVGAVVAADFIESSQARIGFKIYQEAIKQGALIRP
HHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEE
IGNTLYWLPPLNTDKEIIGKLAEITLNSIEKAYNKAQGYE
CCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]