| Definition | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome. |
|---|---|
| Accession | NC_002942 |
| Length | 3,397,754 |
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The map label for this gene is relA
Identifier: 52841687
GI number: 52841687
Start: 1607223
End: 1609427
Strand: Direct
Name: relA
Synonym: lpg1457
Alternate gene names: 52841687
Gene position: 1607223-1609427 (Clockwise)
Preceding gene: 52841686
Following gene: 52841689
Centisome position: 47.3
GC content: 40.27
Gene sequence:
>2205_bases ATGGTAAGAGTAAAAGATACGACTCCGTTGACGCCAGATGGCAGTATTGACGTAGAGATGTGGTTACATCATCTTGGTTC AAAAGGATATTTGGATAATCTCGAACTCGTAAGAGCTGCCTGTACTTTAAGTCAATTGGCTGGGCAGGATCATGCTACTG AAACAGGGCAAACTTGTTTACAACAAGGGTTATCAATGGCTGATTTACTTGCTGACCTGGAAGTAGATCAGGAAACTCTG GCTGCCGCTATTATTTTTGAAAATGTTCATTATGCGGATTTATCTATTGACGATGTTGAAGAGCAATTGGGGCACAATAT CGCTAAATTGGTCAAAGGCATAGAAAAAATGAGTGCCATGAACAATTTCCAGGCTTTAAATAAATACCCGCAAAACAAAA ATCAAATTGACAATATTCGCAAAATGCTTCTTGCGATGGTTGATGATGTGCGAGTTGTTTTAATCAAGCTGGCAGAGTGT TTATGTATTTTAAGAACAGCAGGGCATCTGTCTGAAACGGTACGTAAACAGCTGGCAACCGAAGCCATGGAAATTTACGC GCCTTTAGCTAACCGCTTGGGAATAGGGGCAATCAAGTGGGAAATGGAAGATTTGGCTTTCCGGCATTTGCATCCAGAAG AATATAAGGCGATTGCCAAGGGATTGAAGGCTAAACGATTGGAAAGGGACAGCTTTGTCAATCGCATTGTCGAACAGCTT GAACATCAGATTCGAGCAACAGGAGCTCGCCACTTTGCCGTTTATGGTCGCTCAAAACATATCCATAGTATTTATAAAAA GATGAAGCGTAAAAATGTATCATTAGACGAGATATATGATGCAACAGCGGTTCGTATTCTGGTAGATACTGAAGCACAAT GTTACGAAGTGTTAGGCATGGTTCATACTTTGTGGAAGCAAATTCCAGCAGAGTTTGATGATTACATCATCAATCCAAAA TCCAATGGCTATCAGTCTCTTCATACCGCAGTAGAGGGTCCGGAAGGAAGAGTTTTTGAAGTGCAAATCAGAACTTTTCA TATGCATGATTTAGCAGAAATGGGTGTGGCAGCCCATTGGAAATATAAAGAGGGCGCGGTATCACAAAAAGAGAGCCATG AGCGCAAAATAGAATGGTTAAGAGACGTTTTGGCGTGGCACCAGGAAATGGCAGCTAATAAAGGTGTCGCAGAAAACGTT ACGACTGAGTTTCTTGAAGACAGAGTGTATGTATTTACTCCCGATGGCGATGTGTTGGATTTACCCCATGGGGTGACTCC TTTGGATTTTGCTTATCATGTGCATAGTAATTTGGGACATCGTTGCCGAGGTGCCAAGGTTAATGGTCATATTGTCCCAT TGACTTATCAATTGAAAACAGGAGATAGGGTTGAAGTACTGACTGGAAAAGAAATCAAACCATCAAGGGATTGGATTAAT CCTCATCTGAATTATTTAAAGACCGCAAGAGCCAAGGCTAAAGTATTGCATTGGTTTAAAATGCAAGATTATGAAGATAA TGTGAGAGATGGTCGTGAGTTATTGGAGAAGGAATTAAAATCTTTAGGTATTAAATCGGATAAACTCAATGAAGTTATTA CGGCATTGAATTATAAAAAGGCGGATGATCTTTATGCCAGCTTGGGACGAGGTGATATTAAAATAGGTCAAATTGTTAAT CGATTGGCACCTCCAGATACTTCAGAACAAAATTTACAGAAGTTTGTAAGACAGCAACAAAAACCAGAGGTCACAGGGAG TGATCTTCGTATTGAGGGAGTTGGGAACTTATTGACATTTATGGCAAGATGCTGCCAACCTGTTCCCGGTGATGAAATAG TAGGATACATCACGATTGGAAGGGGGGTTTCCGTTCATCGAAAAGATTGTCCTAATATTATACATGCCAGTGAAAAGCAA AAGCGACGGTTTATTCAGGTGAATTGGGGTACAGCAACACGGGAAAATTATGTTGTTGATGTGTTGATTAAAGCCTTTGA TCGCTCCGAGTTATTGAAGGATGTTACTTCGCTGCTTTCAAATGAAAAAGCCCATGTTTATGCTTTACAGACCCATAGCA ATAAACATGAAAATATGGCTTATATCACTTTAACTGTTGAGATCGATGGTTTAAACAGTTTGTCGCGCTTATTAACTAAA CTGGAGCAAATTCCTAACGTGCTGGAAGCAAGAAGGCAATTATAG
Upstream 100 bases:
>100_bases ATCAAAAAGGTTACGTTTTGATAACAGCTGGGGTAATGGATATGTTTCCTCATACAGCGCATGTCGAGTCTATTGCCTTG TTTCAAAAAGGATAATATGT
Downstream 100 bases:
>100_bases CTTTGGTATATTTAGCCAGAGCCTTCTCAAAAAATTGATATTAGAAGATAAACCCTGCAACAACCGCTCTGTGTTCGCTC AATAAGACGTTATAAGTTCT
Product: GTP pyrophosphokinase ((p)ppGpp synthetase I) stringent stress response RelA
Products: NA
Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]
Number of amino acids: Translated: 734; Mature: 734
Protein sequence:
>734_residues MVRVKDTTPLTPDGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC LCILRTAGHLSETVRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN RLAPPDTSEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK LEQIPNVLEARRQL
Sequences:
>Translated_734_residues MVRVKDTTPLTPDGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC LCILRTAGHLSETVRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN RLAPPDTSEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK LEQIPNVLEARRQL >Mature_734_residues MVRVKDTTPLTPDGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCLQQGLSMADLLADLEVDQETL AAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAMNNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAEC LCILRTAGHLSETVRKQLATEAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGMVHTLWKQIPAEFDDYIINPK SNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHWKYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENV TTEFLEDRVYVFTPDGDVLDLPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKKADDLYASLGRGDIKIGQIVN RLAPPDTSEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTFMARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQ KRRFIQVNWGTATRENYVVDVLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK LEQIPNVLEARRQL
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ACT domain [H]
Homologues:
Organism=Escherichia coli, GI1789147, Length=747, Percent_Identity=44.7121820615797, Blast_Score=653, Evalue=0.0, Organism=Escherichia coli, GI1790082, Length=713, Percent_Identity=33.8008415147265, Blast_Score=426, Evalue=1e-120,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5 [H]
Molecular weight: Translated: 83307; Mature: 83307
Theoretical pI: Translated: 7.09; Mature: 7.09
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVRVKDTTPLTPDGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCL CEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH QQGLSMADLLADLEVDQETLAAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAM HHCCCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH NNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAECLCILRTAGHLSETVRKQLAT HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL HHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGM HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHH VHTLWKQIPAEFDDYIINPKSNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHW HHHHHHHCCCCHHCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHCCHHEEE KYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENVTTEFLEDRVYVFTPDGDVLD CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEE LPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCC PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKK HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH ADDLYASLGRGDIKIGQIVNRLAPPDTSEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTF HHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH MARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQKRRFIQVNWGTATRENYVVD HHHHCCCCCCCCEEEEEEECCCCEECHHCCCCHHCCCCHHCCCEEEEECCCCCCCCHHHH VLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK HHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHH LEQIPNVLEARRQL HHHHHHHHHHHHCC >Mature Secondary Structure MVRVKDTTPLTPDGSIDVEMWLHHLGSKGYLDNLELVRAACTLSQLAGQDHATETGQTCL CEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH QQGLSMADLLADLEVDQETLAAAIIFENVHYADLSIDDVEEQLGHNIAKLVKGIEKMSAM HHCCCHHHHHHHCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH NNFQALNKYPQNKNQIDNIRKMLLAMVDDVRVVLIKLAECLCILRTAGHLSETVRKQLAT HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EAMEIYAPLANRLGIGAIKWEMEDLAFRHLHPEEYKAIAKGLKAKRLERDSFVNRIVEQL HHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH EHQIRATGARHFAVYGRSKHIHSIYKKMKRKNVSLDEIYDATAVRILVDTEAQCYEVLGM HHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCEEEEEECCCHHHHHHHHH VHTLWKQIPAEFDDYIINPKSNGYQSLHTAVEGPEGRVFEVQIRTFHMHDLAEMGVAAHW HHHHHHHCCCCHHCEEECCCCCCHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHCCHHEEE KYKEGAVSQKESHERKIEWLRDVLAWHQEMAANKGVAENVTTEFLEDRVYVFTPDGDVLD CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCCCCEEE LPHGVTPLDFAYHVHSNLGHRCRGAKVNGHIVPLTYQLKTGDRVEVLTGKEIKPSRDWIN CCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCHHHCC PHLNYLKTARAKAKVLHWFKMQDYEDNVRDGRELLEKELKSLGIKSDKLNEVITALNYKK HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCH ADDLYASLGRGDIKIGQIVNRLAPPDTSEQNLQKFVRQQQKPEVTGSDLRIEGVGNLLTF HHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHH MARCCQPVPGDEIVGYITIGRGVSVHRKDCPNIIHASEKQKRRFIQVNWGTATRENYVVD HHHHCCCCCCCCEEEEEEECCCCEECHHCCCCHHCCCCHHCCCEEEEECCCCCCCCHHHH VLIKAFDRSELLKDVTSLLSNEKAHVYALQTHSNKHENMAYITLTVEIDGLNSLSRLLTK HHHHHHCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEEEEECCCHHHHHHHHH LEQIPNVLEARRQL HHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11206551; 11258796 [H]