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The map label for this gene is trpS

Identifier: 52841674

GI number: 52841674

Start: 1592224

End: 1593441

Strand: Direct

Name: trpS

Synonym: lpg1444

Alternate gene names: 52841674

Gene position: 1592224-1593441 (Clockwise)

Preceding gene: 52841673

Following gene: 52841675

Centisome position: 46.86

GC content: 39.57

Gene sequence:

>1218_bases
TTGATGTCAGCACTGTTTACTTCCAATAAGCGAGTCGTTTCTGGAATGCGGGTCAGTGGAAGATTGCATTTAGGTCATTA
TCATGGTGTTTTAAAAAATTGGATAAAATTACAACATCAATACGATTGTTTCTTTTTTGCAGCAGATTGGCATGGCCTAA
CAACACAATATGAAGACCCCAATTTTATTGAAAAACACCTCTGGGATATGATTATTGATTGGCTAGCTTGTGGAGTTAAT
CCAGGCTTGTGTAAGATATTTATTCAATCCTGGGTTCCAGAGCATGCTGAATTACATTTACTTTTGTCCATGATCACTCC
TTTAGGTTGGTTGGAGCGAGTTCCTACTTATAAAGATCAGCAGGAGAAATTAAAAGAAAAAGATTTATCAACCTATGGTT
TTTTGGGATATCCATTACTACAAAGTGCTGATGTACTTTTATACCACGCGGATTATGTTCCAGTGGGTGAAGACCAAGTG
GCTCATATTGAGTTAACACGAGAAATAGCCCGAAGATTTAACTATCTTTATGGTAGAGAGGCTAATTTTGAGGAGCTGGC
TGCTGCAGCAATCAAAAAGATGGGTAAAAAGAATGGGAAAATTTATACCGAATTACGCAGACAATTTCAGGAGCATGGCA
TCCACGAATCGATTAAGACAGCACAAGCGCTTTTAGAAGATCAGCCTAATTTGTCGATTGGAGATAAAGAGCGATTGTTG
GGATATTTGGAAGGAAGTGGCAAAATTATATTAAACGAACCACAGCCTTTGCTTACGGAAACTGCAAAAATGCCTGGTCT
TGATGGGCAGAAAATGTCCAAATCTTACCATAATACGATCATGCTAAGAGATGAGCCAGCTTTAGTTGAAAAGAAAATTC
TGACTATGCCCACGGATCCGGCGCGTGTTAAACGTACAGATCCAGGAGAGCCTGAAAAATGTCCTGTTTGGCAATTCCAT
AAAGTGTATTCTAATGAGGAAGTAAAAGATTGGGTGCAAAAAGGTTGCCGAACAGCAGGAATTGGTTGCGTTGACTGTAA
GAGACCAGTGATTGGTGCTATCCATCAAGAACTTAAACCAATACAGGAAGCGATTTCAGATTATGAAGCTGATTTAGGTT
CGGTAAAACGTATTGTAGCGGAAGGAAGCGAAGCGGCCAGAGAAGAAGGAAACAAGACTTTAAATACGGTCAGAGAAGTC
ATGGGGCTTGATTATTAA

Upstream 100 bases:

>100_bases
TGGATAAAATATGATTGAAGCAAGCATCAGGTTAGAATTCAGGGAATAAAGAAATTTTTGTATTTGAAATAATTGATTAA
TTTATAACAAGAAGAGGAAA

Downstream 100 bases:

>100_bases
TGAATATCGATTTGCAGCCTGCGCCTGTAGTCAAAGCGGTGGTGGATGGTAAGGAAATTACTCAGTTTCCAGAGGATTTA
TATATTCCTCCTGATGCATT

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MMSALFTSNKRVVSGMRVSGRLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVN
PGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQV
AHIELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLL
GYLEGSGKIILNEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFH
KVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREV
MGLDY

Sequences:

>Translated_405_residues
MMSALFTSNKRVVSGMRVSGRLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVN
PGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQV
AHIELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLL
GYLEGSGKIILNEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFH
KVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREV
MGLDY
>Mature_405_residues
MMSALFTSNKRVVSGMRVSGRLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDPNFIEKHLWDMIIDWLACGVN
PGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQQEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQV
AHIELTREIARRFNYLYGREANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLL
GYLEGSGKIILNEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDPARVKRTDPGEPEKCPVWQFH
KVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKPIQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREV
MGLDY

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=188, Percent_Identity=40.4255319148936, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI41352700, Length=172, Percent_Identity=42.4418604651163, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=42.5149700598802, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71982800, Length=171, Percent_Identity=35.0877192982456, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71982793, Length=171, Percent_Identity=35.0877192982456, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6320474, Length=192, Percent_Identity=35.4166666666667, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24666151, Length=399, Percent_Identity=28.3208020050125, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 46194; Mature: 46194

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSALFTSNKRVVSGMRVSGRLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDP
CCCCHHCCCCHHHCCEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
NFIEKHLWDMIIDWLACGVNPGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQ
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
QEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVAHIELTREIARRFNYLYGRE
HHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
GYLEGSGKIILNEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDP
HHCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCC
ARVKRTDPGEPEKCPVWQFHKVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKP
CCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
IQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVMGLDY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMSALFTSNKRVVSGMRVSGRLHLGHYHGVLKNWIKLQHQYDCFFFAADWHGLTTQYEDP
CCCCHHCCCCHHHCCEEECCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCC
NFIEKHLWDMIIDWLACGVNPGLCKIFIQSWVPEHAELHLLLSMITPLGWLERVPTYKDQ
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCH
QEKLKEKDLSTYGFLGYPLLQSADVLLYHADYVPVGEDQVAHIELTREIARRFNYLYGRE
HHHHHHHCCCCCCCCCCHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ANFEELAAAAIKKMGKKNGKIYTELRRQFQEHGIHESIKTAQALLEDQPNLSIGDKERLL
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHH
GYLEGSGKIILNEPQPLLTETAKMPGLDGQKMSKSYHNTIMLRDEPALVEKKILTMPTDP
HHCCCCCEEEEECCCHHHHHHHCCCCCCHHHHHHHHCCEEEECCCCHHHHHHHHCCCCCC
ARVKRTDPGEPEKCPVWQFHKVYSNEEVKDWVQKGCRTAGIGCVDCKRPVIGAIHQELKP
CCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
IQEAISDYEADLGSVKRIVAEGSEAAREEGNKTLNTVREVMGLDY
HHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]