Click here to switch to the map view.

The map label for this gene is cpxA

Identifier: 52841667

GI number: 52841667

Start: 1585925

End: 1587319

Strand: Reverse

Name: cpxA

Synonym: lpg1437

Alternate gene names: 52841667

Gene position: 1587319-1585925 (Counterclockwise)

Preceding gene: 52841668

Following gene: 52841666

Centisome position: 46.72

GC content: 39.14

Gene sequence:

>1395_bases
CTGTCCGCGGGTTTGGGTACATGTTTAATGCGTAGTCTGTACTGGAAAATATTTGTTTCTTTTTGGCTGGCCACCATTTT
AATTATTTTTACTACGGCATGGGTTACCAGCCAAATCGCACAAAAATCATCACAACCAGCTCGAGAGGAAATGTTCATGG
ACAGCTATGCCAATGCAGCTGTCGCAACCTATGAGTCAGGCCAACAATCAGCACTTTTGAAATGGCTTGATAAAATAGGC
CTTTCTCGTCATATGACACTGTATTTACTAACCAGCACCGGCGAAATCATTGGCGCACAGAAACCACCTGACGCCGTAAA
AAAAATTTCAGAAAATTTAATAAATGATGAACTCCCAAGTGATGGCATATTTAAAACAGGGAAATTAGTCGTTAGCCATG
AGATCCTATCAACTTCTGGAAAATATTACCGGCTAGCAGCTGTCAGTGAAAAGCCAATCTCTTATTTTGTGCAAATTCCA
TGGGCTGGACTGACAATACGTTTAACTCTGGCTATATTCATCAGTGGGCTTATCTGCTATTTACTCTCACGTTATTTAAC
TCAACCTTTACGCTCATTAGGCATGGCAGCAAAATCTATCGCTAAAGGAAATTTAAATACCCGGGTTGGTCGCTTCAGAG
GTCATAGTAAAGATGAGATTGCGGAGTTAAGTAATGAATTCGATCGAATGGCCGAGCAATTAGAAGCGCTTGTTCATTCC
AAAGAACGATTAATACAGGATATTTCCCACGAATTACGCTCTCCATTGGCTCGACTTAAAATCGCCATAGAATTAGGGAA
AAAGAAAACCAAGCATTTGGCTGATAATGAATTTGCCCGCATGGAAATTGAAACATCCAGACTTAATGATTTGATAGGCG
AAATTCTCGATTTTGCTCGTTTAGAAAAATCGACAACAGAACTTCATTTATCCCAAACAAATATCGCGGATTTGCTTGCA
CAGGTTATAAGTGATGCCAATTATGAGTTCAGTCACAATTCTATAAGAATACAAGCTGGAATAATTACACCTTGTGAATT
AAATATTGACCAACGCCTAATACACAGAGCTATAGAAAATATTGTTCGTAATGCATCACACTATTCTCCTCCAGATGAAA
AGGTCCTGATTTCATCAAGCTATGATAAAAACAAAGATCAAGTTTATATTGATATTAATGATAAAGGACCTGGGGTTCCC
GAAGATCAACTGGAAAAAATATTTAATCCTTTCTACCGCGTGGATACCTCCAGAACAAAAAAAACCGGTGGCTATGGGCT
TGGGCTCGCAATTGCAGCTAGGGCTGTAGCATTACACCAAGGAGAAATTATTGCTAAAAATAGAGAGCAAGGTGGTTTGC
TTGTTCGTATCATTTTACCTGCTGATGTTAAATAG

Upstream 100 bases:

>100_bases
GGAAGAAAATACACTGCTTATGACCGCAGTATCGATGTTCACATCAGCAATTTGCGAAATAAATTAGGCGATAATCCTCA
GGGAGAACCTTTAGTCAAAA

Downstream 100 bases:

>100_bases
GATTTCTATATATCGAGTTCCTCCTTATTGACTAAAATTGATTTTTGACTTGCATTTTTATTATCTAATTCCGTATACAT
ACAAATAATTATACATTTTG

Product: sensor histidine kinase CpxA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSAGLGTCLMRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIG
LSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIP
WAGLTIRLTLAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHS
KERLIQDISHELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLA
QVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYDKNKDQVYIDINDKGPGVP
EDQLEKIFNPFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK

Sequences:

>Translated_464_residues
MSAGLGTCLMRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIG
LSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIP
WAGLTIRLTLAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHS
KERLIQDISHELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLA
QVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYDKNKDQVYIDINDKGPGVP
EDQLEKIFNPFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
>Mature_463_residues
SAGLGTCLMRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAAVATYESGQQSALLKWLDKIGL
SRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPSDGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPW
AGLTIRLTLAIFISGLICYLLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHSK
ERLIQDISHELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFARLEKSTTELHLSQTNIADLLAQ
VISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIENIVRNASHYSPPDEKVLISSSYDKNKDQVYIDINDKGPGVPE
DQLEKIFNPFYRVDTSRTKKTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=390, Percent_Identity=31.2820512820513, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787894, Length=307, Percent_Identity=31.2703583061889, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=28.6666666666667, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=27.4368231046931, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786783, Length=278, Percent_Identity=27.3381294964029, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1786600, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790551, Length=295, Percent_Identity=25.7627118644068, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1790861, Length=245, Percent_Identity=27.3469387755102, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082128, Length=309, Percent_Identity=25.5663430420712, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786912, Length=244, Percent_Identity=27.8688524590164, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI145693157, Length=231, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=25.8474576271186, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787374, Length=312, Percent_Identity=24.6794871794872, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1789149, Length=408, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=234, Percent_Identity=28.2051282051282, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788549, Length=249, Percent_Identity=26.5060240963855, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=247, Percent_Identity=28.3400809716599, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081816, Length=257, Percent_Identity=27.2373540856031, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=250, Percent_Identity=24.8, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790300, Length=236, Percent_Identity=26.271186440678, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51859; Mature: 51728

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGLGTCLMRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCE
VATYESGQQSALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPS
EEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
DGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICY
CCCEECCCEEEEHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KERLIQDISHELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHH
LEKSTTELHLSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIEN
HHCCHHHEEECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHH
IVRNASHYSPPDEKVLISSSYDKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTK
HHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
KTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC
>Mature Secondary Structure 
SAGLGTCLMRSLYWKIFVSFWLATILIIFTTAWVTSQIAQKSSQPAREEMFMDSYANAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCE
VATYESGQQSALLKWLDKIGLSRHMTLYLLTSTGEIIGAQKPPDAVKKISENLINDELPS
EEECCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCC
DGIFKTGKLVVSHEILSTSGKYYRLAAVSEKPISYFVQIPWAGLTIRLTLAIFISGLICY
CCCEECCCEEEEHHHHHCCCCEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LLSRYLTQPLRSLGMAAKSIAKGNLNTRVGRFRGHSKDEIAELSNEFDRMAEQLEALVHS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KERLIQDISHELRSPLARLKIAIELGKKKTKHLADNEFARMEIETSRLNDLIGEILDFAR
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHEEEEHHHHHHHHHHHHHHHHH
LEKSTTELHLSQTNIADLLAQVISDANYEFSHNSIRIQAGIITPCELNIDQRLIHRAIEN
HHCCHHHEEECHHHHHHHHHHHHCCCCCEECCCEEEEEEEEECCCCCCHHHHHHHHHHHH
IVRNASHYSPPDEKVLISSSYDKNKDQVYIDINDKGPGVPEDQLEKIFNPFYRVDTSRTK
HHHCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCC
KTGGYGLGLAIAARAVALHQGEIIAKNREQGGLLVRIILPADVK
CCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]