BacMap

Definition	Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome.
Accession	NC_002942
Length	3,397,754

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The map label for this gene is ucpA [H]

Identifier: 52841657

GI number: 52841657

Start: 1577692

End: 1578471

Strand: Direct

Name: ucpA [H]

Synonym: lpg1427

Alternate gene names: 52841657

Gene position: 1577692-1578471 (Clockwise)

Preceding gene: 52841656

Following gene: 52841658

Centisome position: 46.43

GC content: 37.69

Gene sequence:

>780_bases
ATGATGACCTTAATAACGGGAGCCACGAGAGGTATAGGTTTGGCCTTGGCGTATGAGTTTGCATCACATGGCCATGATTT
AATACTTATTGGTAGAGATTCTGAACAGCTGGAGCACATTTCAAAGCAATTAAATACACAATATCAAGTTAATGTTGAAT
ATAAAGTACATGACTTAAGTAAACCTGGAAGCGCATTTAAGTTGTATACTGATTTAAAAGAGCAGGGTGTAGAAGTCAAC
TGCCTGGTTAATAATGCGGGCATAGGCTATATGGGTTCTTTTGTTGAGATGGGCATGAACAAGCTCGATGATTTAATGAA
CATAAACATGATTTCTTTAAGTGAATTAACACTATGTTTTCTTCATGATTTTGTGGCTCGAAACGAAGGCAGTGTTTTAC
AGGTTTCTTCAACAGCAGCATTTCAACCGGGTCCTTTTATGGCAGCCTACTATGCGAGTAAGGCATATGTGGCAACGCTT
TCCCATGCTATTGCTTATGAGCTTAAAGATACTAAGGTATCTATGTCTATTCTTTGTCCTGGAGCAACAAAAACCAATTT
TTTCCATGCTTCTGGTATGGAAAGTTCTATGTTGGAGAGGGGATATATTGGAATGATGACACCAGAAAAGGTCGCTAAAA
TTGCCTATAAAGGATTAAAAAAAGGAAAGTTGTATATTATTCCGGGGCTAAGAAATAAAATTTTAGCCTATGCAGCAGCC
ATATCACCCAAAGCGATTGCTCTTAGGATCGCATCTTATCTTCATCATAAAATTTTGTAG

Upstream 100 bases:

>100_bases
AATTTGTTAAAACAGGAAAAGCATGACGATGTATCTCGGCTATTGGATTGCCTACGTAACCAAATGGAGCCTGTGCAAAC
AGTAAAAGGAGGAGTGCATC

Downstream 100 bases:

>100_bases
ATGATATGCGGCTTCAATTGATGAAAATAACAGGATTTACTCTACTTGAAACGATGCTTACATTAGCTTTGCTTGTAGGA
TTATTGCTTTTAGGTTCATG

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MMTLITGATRGIGLALAYEFASHGHDLILIGRDSEQLEHISKQLNTQYQVNVEYKVHDLSKPGSAFKLYTDLKEQGVEVN
CLVNNAGIGYMGSFVEMGMNKLDDLMNINMISLSELTLCFLHDFVARNEGSVLQVSSTAAFQPGPFMAAYYASKAYVATL
SHAIAYELKDTKVSMSILCPGATKTNFFHASGMESSMLERGYIGMMTPEKVAKIAYKGLKKGKLYIIPGLRNKILAYAAA
ISPKAIALRIASYLHHKIL

Sequences:

>Translated_259_residues
MMTLITGATRGIGLALAYEFASHGHDLILIGRDSEQLEHISKQLNTQYQVNVEYKVHDLSKPGSAFKLYTDLKEQGVEVN
CLVNNAGIGYMGSFVEMGMNKLDDLMNINMISLSELTLCFLHDFVARNEGSVLQVSSTAAFQPGPFMAAYYASKAYVATL
SHAIAYELKDTKVSMSILCPGATKTNFFHASGMESSMLERGYIGMMTPEKVAKIAYKGLKKGKLYIIPGLRNKILAYAAA
ISPKAIALRIASYLHHKIL
>Mature_259_residues
MMTLITGATRGIGLALAYEFASHGHDLILIGRDSEQLEHISKQLNTQYQVNVEYKVHDLSKPGSAFKLYTDLKEQGVEVN
CLVNNAGIGYMGSFVEMGMNKLDDLMNINMISLSELTLCFLHDFVARNEGSVLQVSSTAAFQPGPFMAAYYASKAYVATL
SHAIAYELKDTKVSMSILCPGATKTNFFHASGMESSMLERGYIGMMTPEKVAKIAYKGLKKGKLYIIPGLRNKILAYAAA
ISPKAIALRIASYLHHKIL

Specific function: Unknown

COG id: COG0300

COG function: function code R; Short-chain dehydrogenases of various substrate specificities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI226371731, Length=198, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI7705855, Length=260, Percent_Identity=25.7692307692308, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4557649, Length=186, Percent_Identity=32.258064516129, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI20149619, Length=252, Percent_Identity=26.5873015873016, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI32483357, Length=220, Percent_Identity=29.0909090909091, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI142976729, Length=190, Percent_Identity=29.4736842105263, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI210032110, Length=250, Percent_Identity=23.6, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI7706318, Length=195, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI33667109, Length=221, Percent_Identity=25.7918552036199, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI109715829, Length=223, Percent_Identity=22.8699551569507, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=194, Percent_Identity=26.8041237113402, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI40807363, Length=257, Percent_Identity=24.124513618677, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI87082100, Length=194, Percent_Identity=30.4123711340206, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1787820, Length=221, Percent_Identity=25.7918552036199, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787335, Length=189, Percent_Identity=24.8677248677249, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=26.7379679144385, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=183, Percent_Identity=27.8688524590164, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082160, Length=186, Percent_Identity=24.1935483870968, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=211, Percent_Identity=30.8056872037915, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25152911, Length=203, Percent_Identity=27.5862068965517, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=200, Percent_Identity=28.5, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=251, Percent_Identity=28.2868525896414, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560220, Length=198, Percent_Identity=29.7979797979798, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562908, Length=208, Percent_Identity=29.8076923076923, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=206, Percent_Identity=28.6407766990291, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=243, Percent_Identity=26.7489711934156, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557668, Length=202, Percent_Identity=25.2475247524752, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17560176, Length=193, Percent_Identity=25.9067357512953, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=249, Percent_Identity=26.1044176706827, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17559552, Length=202, Percent_Identity=26.2376237623762, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212646214, Length=202, Percent_Identity=25.2475247524752, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=247, Percent_Identity=27.5303643724696, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=187, Percent_Identity=24.0641711229947, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=247, Percent_Identity=25.9109311740891, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=192, Percent_Identity=30.7291666666667, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319635, Length=222, Percent_Identity=26.1261261261261, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076933, Length=184, Percent_Identity=30.9782608695652, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24584748, Length=184, Percent_Identity=30.9782608695652, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24584744, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574402, Length=201, Percent_Identity=29.8507462686567, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24644339, Length=199, Percent_Identity=30.1507537688442, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24640442, Length=190, Percent_Identity=33.6842105263158, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24584752, Length=198, Percent_Identity=28.2828282828283, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=29.3193717277487, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=30.7377049180328, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356301, Length=286, Percent_Identity=26.9230769230769, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=200, Percent_Identity=27.5, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24580925, Length=243, Percent_Identity=26.7489711934156, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358495, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 28416; Mature: 28416

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMTLITGATRGIGLALAYEFASHGHDLILIGRDSEQLEHISKQLNTQYQVNVEYKVHDLS
CEEEEECCCCCCHHEEEEEHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEEEEEECC
KPGSAFKLYTDLKEQGVEVNCLVNNAGIGYMGSFVEMGMNKLDDLMNINMISLSELTLCF
CCCCEEEEEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
LHDFVARNEGSVLQVSSTAAFQPGPFMAAYYASKAYVATLSHAIAYELKDTKVSMSILCP
HHHHHHCCCCCEEEEECCCCCCCCCCEEEHHHCHHHHHHHHHHHHEEECCCEEEEEEEEC
GATKTNFFHASGMESSMLERGYIGMMTPEKVAKIAYKGLKKGKLYIIPGLRNKILAYAAA
CCCCCCEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
ISPKAIALRIASYLHHKIL
CCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMTLITGATRGIGLALAYEFASHGHDLILIGRDSEQLEHISKQLNTQYQVNVEYKVHDLS
CEEEEECCCCCCHHEEEEEHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEEEEEECC
KPGSAFKLYTDLKEQGVEVNCLVNNAGIGYMGSFVEMGMNKLDDLMNINMISLSELTLCF
CCCCEEEEEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
LHDFVARNEGSVLQVSSTAAFQPGPFMAAYYASKAYVATLSHAIAYELKDTKVSMSILCP
HHHHHHCCCCCEEEEECCCCCCCCCCEEEHHHCHHHHHHHHHHHHEEECCCEEEEEEEEC
GATKTNFFHASGMESSMLERGYIGMMTPEKVAKIAYKGLKKGKLYIIPGLRNKILAYAAA
CCCCCCEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHH
ISPKAIALRIASYLHHKIL
CCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]