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The map label for this gene is pbpA

Identifier: 52841605

GI number: 52841605

Start: 1521417

End: 1523297

Strand: Reverse

Name: pbpA

Synonym: lpg1375

Alternate gene names: 52841605

Gene position: 1523297-1521417 (Counterclockwise)

Preceding gene: 52841606

Following gene: 52841604

Centisome position: 44.83

GC content: 39.98

Gene sequence:

>1881_bases
TTGTTTTGTCATACAACATTTTCTGCGATGTATCGGAATCAATCATTTAAAAACTATCGTGCTGAATCCCAACATCAACG
ATTTAGACTTAATCTGTTAATTGCGATTCTGATTATTTTATCTTTAATACTGATTTTAAGATTGGCCTTCCTGCAAATAT
CCGAATTTAAACGGTATCAGACCTTGTCTTTAAAAAATCAAATGAGCGTAATACCTATTGCTCCTCCAAGAGGGGTTATT
TTGGATAGAAATGGAGTATTACTCGCTGAAAACATACCAGTGTATGTGCTGGAAATCACTCCCGAACGTGTTAAAGACAT
GAAACAGACTTTGACTAAACTTCGAGAGTTAATTCCTTCAATTACAGACGAAGATATTGATAGCTTCAATAAGACCAGAT
TACAAAATCGTTCTTTTGTTCCCATTCCTATCAAATTAAAATTAAGCCAGGAAGAAGTAGCTACCTTTGCCAGCAATCAG
TATCATTTCCCGGGAGTAAGCATTAAAGCGAGATTGATGCGTCATTACCCTCTTGGAGAGATTACTGCCCACGCCTTGGG
GTATGTTGGTCGTATTAATATTCAGGAACTAAAACAAGTGGACTCCACTAATTATCGTGCTACCAACTTTATTGGCAAGG
CCGGTATTGAAAAATACTATGAAGATATTCTCCATGGTAAAGTGGGTTATCAAATGGTAGAAACTGATGTTAGTGGCCGC
ACTTTAAGAATAATAAATAAAGTCAATCCTCATTCAGGAGCGAAACTGTATTTAAGCATAGACGCCAGACTTCAGGAAGC
AGCTTATAATGCATTGAAGGATAAACGAGGTGCGGTAGTAGTCATAAACTCTCGGAATGGCGAAGTACTTGCGATGGTGA
GTTCTCCAAGTTTTGATCCCAATATTTTCGTCAGTGGAGTCAGTAAAGCGGATTATAAAGTGTTATCCAATGCCCTCCAG
CGCCCTCTTTTTAATCGAGCAGTTCGAGGCGTTTACCCCCCTGCATCAACAATCAAACCGTTTGTTGGACTGGCTGGTTT
GGATAAAGGCTTCATTACCACGACCACTGAAATATATGACCCCGGTAAGTACAAACTCCCTACTTCCAGCCATGTTTACC
GTGATTGGAAAAAAACAGGCCACGGGGTCATTAATTTCAAACGAGCCATTACCGTCTCTTGTGACACTTTTTTTTACCAA
CTAGGTAATAAAATGGGAATCTCTAACATTGAGGACATGCTTGTAAAATTTGGCTTGGGACAACTAACACACGTTGACCT
TCATGAAGAAGCAAATGGAGTAATACCTAGCGCTCGCTGGAAAAGACAAACTAAAGGAGTATCCTGGTATCCTGGAGATA
CTCTCATTTCTGCAATAGGACAAGGATTTATGCTGGCAACCCCTTTGCAAATGGCTAATGCCACAGCTTCCCTAAGCCAG
CATGGACAACGATTCAGACCTCACCTACTGATAAAAACAGTAAACAGCGATACCAATGAAATGGAAGAATACAAGCCTTT
TGAAGAATACCCAGTTTCCCTGAGAGATGAAGCAAACTGGGATGTTGTGATTGATGCGATGCATAGCGTACTAACCAGCA
ATGAAGGAACAGGTTACCGTTTTGGCAGAAATCCTCCTTACCCGGTAGCAGGAAAAACAGGTACAGCACAAGTATACAGC
GGAAGACAATATGAAAAGGCAAAGTACGAAGACATACCTGAGCATTTGAGGGATAATTCTTTATTTATTGCATTTACTCC
AGTAGAAAAACCGGAAATTGCCATTGCGGTGGTAGTTGAAAATGATACTATCGCTTCCACTGTAGCACGTAAGGTACTTG
ACACTTATTATCAACTTTATCCTATTAAGAAAACACCATGA

Upstream 100 bases:

>100_bases
TAGAAAAATTTGACTCTAATCTCAAAAAATGAAAAACCACAAGCTTTATAAATATTTTATAATTGGTAAAAATCTGTAAT
TTCAGGTACTATTCCTACTT

Downstream 100 bases:

>100_bases
GTAGACAAACGACTAAGCCCGTATATCGTTTTACAGCAAAGTCCCTTCATCTTGATTTTCCATTACTTGGATTAATACTT
ACTCTTATTGCCTTCGGACT

Product: penicillin binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MFCHTTFSAMYRNQSFKNYRAESQHQRFRLNLLIAILIILSLILILRLAFLQISEFKRYQTLSLKNQMSVIPIAPPRGVI
LDRNGVLLAENIPVYVLEITPERVKDMKQTLTKLRELIPSITDEDIDSFNKTRLQNRSFVPIPIKLKLSQEEVATFASNQ
YHFPGVSIKARLMRHYPLGEITAHALGYVGRINIQELKQVDSTNYRATNFIGKAGIEKYYEDILHGKVGYQMVETDVSGR
TLRIINKVNPHSGAKLYLSIDARLQEAAYNALKDKRGAVVVINSRNGEVLAMVSSPSFDPNIFVSGVSKADYKVLSNALQ
RPLFNRAVRGVYPPASTIKPFVGLAGLDKGFITTTTEIYDPGKYKLPTSSHVYRDWKKTGHGVINFKRAITVSCDTFFYQ
LGNKMGISNIEDMLVKFGLGQLTHVDLHEEANGVIPSARWKRQTKGVSWYPGDTLISAIGQGFMLATPLQMANATASLSQ
HGQRFRPHLLIKTVNSDTNEMEEYKPFEEYPVSLRDEANWDVVIDAMHSVLTSNEGTGYRFGRNPPYPVAGKTGTAQVYS
GRQYEKAKYEDIPEHLRDNSLFIAFTPVEKPEIAIAVVVENDTIASTVARKVLDTYYQLYPIKKTP

Sequences:

>Translated_626_residues
MFCHTTFSAMYRNQSFKNYRAESQHQRFRLNLLIAILIILSLILILRLAFLQISEFKRYQTLSLKNQMSVIPIAPPRGVI
LDRNGVLLAENIPVYVLEITPERVKDMKQTLTKLRELIPSITDEDIDSFNKTRLQNRSFVPIPIKLKLSQEEVATFASNQ
YHFPGVSIKARLMRHYPLGEITAHALGYVGRINIQELKQVDSTNYRATNFIGKAGIEKYYEDILHGKVGYQMVETDVSGR
TLRIINKVNPHSGAKLYLSIDARLQEAAYNALKDKRGAVVVINSRNGEVLAMVSSPSFDPNIFVSGVSKADYKVLSNALQ
RPLFNRAVRGVYPPASTIKPFVGLAGLDKGFITTTTEIYDPGKYKLPTSSHVYRDWKKTGHGVINFKRAITVSCDTFFYQ
LGNKMGISNIEDMLVKFGLGQLTHVDLHEEANGVIPSARWKRQTKGVSWYPGDTLISAIGQGFMLATPLQMANATASLSQ
HGQRFRPHLLIKTVNSDTNEMEEYKPFEEYPVSLRDEANWDVVIDAMHSVLTSNEGTGYRFGRNPPYPVAGKTGTAQVYS
GRQYEKAKYEDIPEHLRDNSLFIAFTPVEKPEIAIAVVVENDTIASTVARKVLDTYYQLYPIKKTP
>Mature_626_residues
MFCHTTFSAMYRNQSFKNYRAESQHQRFRLNLLIAILIILSLILILRLAFLQISEFKRYQTLSLKNQMSVIPIAPPRGVI
LDRNGVLLAENIPVYVLEITPERVKDMKQTLTKLRELIPSITDEDIDSFNKTRLQNRSFVPIPIKLKLSQEEVATFASNQ
YHFPGVSIKARLMRHYPLGEITAHALGYVGRINIQELKQVDSTNYRATNFIGKAGIEKYYEDILHGKVGYQMVETDVSGR
TLRIINKVNPHSGAKLYLSIDARLQEAAYNALKDKRGAVVVINSRNGEVLAMVSSPSFDPNIFVSGVSKADYKVLSNALQ
RPLFNRAVRGVYPPASTIKPFVGLAGLDKGFITTTTEIYDPGKYKLPTSSHVYRDWKKTGHGVINFKRAITVSCDTFFYQ
LGNKMGISNIEDMLVKFGLGQLTHVDLHEEANGVIPSARWKRQTKGVSWYPGDTLISAIGQGFMLATPLQMANATASLSQ
HGQRFRPHLLIKTVNSDTNEMEEYKPFEEYPVSLRDEANWDVVIDAMHSVLTSNEGTGYRFGRNPPYPVAGKTGTAQVYS
GRQYEKAKYEDIPEHLRDNSLFIAFTPVEKPEIAIAVVVENDTIASTVARKVLDTYYQLYPIKKTP

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=614, Percent_Identity=42.9967426710098, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1786272, Length=618, Percent_Identity=24.9190938511327, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70585; Mature: 70585

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCHTTFSAMYRNQSFKNYRAESQHQRFRLNLLIAILIILSLILILRLAFLQISEFKRYQ
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSLKNQMSVIPIAPPRGVILDRNGVLLAENIPVYVLEITPERVKDMKQTLTKLRELIPS
HEECCCCCEEEEECCCCCEEECCCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
ITDEDIDSFNKTRLQNRSFVPIPIKLKLSQEEVATFASNQYHFPGVSIKARLMRHYPLGE
CCCHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHCCCEECCCCHHHHHHHHHCCCHH
ITAHALGYVGRINIQELKQVDSTNYRATNFIGKAGIEKYYEDILHGKVGYQMVETDVSGR
HHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TLRIINKVNPHSGAKLYLSIDARLQEAAYNALKDKRGAVVVINSRNGEVLAMVSSPSFDP
EEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCC
NIFVSGVSKADYKVLSNALQRPLFNRAVRGVYPPASTIKPFVGLAGLDKGFITTTTEIYD
CEEEECCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEHEEEC
PGKYKLPTSSHVYRDWKKTGHGVINFKRAITVSCDTFFYQLGNKMGISNIEDMLVKFGLG
CCCEECCCCHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCC
QLTHVDLHEEANGVIPSARWKRQTKGVSWYPGDTLISAIGQGFMLATPLQMANATASLSQ
CEEEEECHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHH
HGQRFRPHLLIKTVNSDTNEMEEYKPFEEYPVSLRDEANWDVVIDAMHSVLTSNEGTGYR
CCHHCCCEEEEEEECCCHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
FGRNPPYPVAGKTGTAQVYSGRQYEKAKYEDIPEHLRDNSLFIAFTPVEKPEIAIAVVVE
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEE
NDTIASTVARKVLDTYYQLYPIKKTP
CCHHHHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MFCHTTFSAMYRNQSFKNYRAESQHQRFRLNLLIAILIILSLILILRLAFLQISEFKRYQ
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLSLKNQMSVIPIAPPRGVILDRNGVLLAENIPVYVLEITPERVKDMKQTLTKLRELIPS
HEECCCCCEEEEECCCCCEEECCCCEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHCC
ITDEDIDSFNKTRLQNRSFVPIPIKLKLSQEEVATFASNQYHFPGVSIKARLMRHYPLGE
CCCHHHHHHHHHHHCCCCCCEEEEEEEECHHHHHHHHCCCEECCCCHHHHHHHHHCCCHH
ITAHALGYVGRINIQELKQVDSTNYRATNFIGKAGIEKYYEDILHGKVGYQMVETDVSGR
HHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
TLRIINKVNPHSGAKLYLSIDARLQEAAYNALKDKRGAVVVINSRNGEVLAMVSSPSFDP
EEEEEECCCCCCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCCC
NIFVSGVSKADYKVLSNALQRPLFNRAVRGVYPPASTIKPFVGLAGLDKGFITTTTEIYD
CEEEECCCHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEEEEHEEEC
PGKYKLPTSSHVYRDWKKTGHGVINFKRAITVSCDTFFYQLGNKMGISNIEDMLVKFGLG
CCCEECCCCHHHHHHHHHCCCCEEEEEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCC
QLTHVDLHEEANGVIPSARWKRQTKGVSWYPGDTLISAIGQGFMLATPLQMANATASLSQ
CEEEEECHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCEEECCHHHHHHHHHHHH
HGQRFRPHLLIKTVNSDTNEMEEYKPFEEYPVSLRDEANWDVVIDAMHSVLTSNEGTGYR
CCHHCCCEEEEEEECCCHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
FGRNPPYPVAGKTGTAQVYSGRQYEKAKYEDIPEHLRDNSLFIAFTPVEKPEIAIAVVVE
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEE
NDTIASTVARKVLDTYYQLYPIKKTP
CCHHHHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]