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The map label for this gene is fadB

Identifier: 52841582

GI number: 52841582

Start: 1492611

End: 1494980

Strand: Direct

Name: fadB

Synonym: lpg1352

Alternate gene names: 52841582

Gene position: 1492611-1494980 (Clockwise)

Preceding gene: 52841581

Following gene: 52841583

Centisome position: 43.93

GC content: 39.24

Gene sequence:

>2370_bases
ATGCAGGAGCCTTTTTTCATTAAAAAAGTTGCAGTTTTAGGGGCTGGCGTCATGGGTGCTCAAATTGCAGCACACTGCGT
TAATGCCGGAATAGAGACTTTACTGTTTGATTTAGCTGGCAAAGAAGGGCCTAAAAACAGCTTGGTCGATAAAGCTATTG
CCAATTTAGGTAAACTAAAACCAACTCCTCTTGCAACTCCCCAAACCAATGAGTTATTACAAGCAAAAAATTATGCGGAA
AATTTGGAAGAGTTATCTTCTTGTGATTTAGTCATAGAGGCGATAGCGGAACGTGTAGATTGGAAAGAGGACTTATACAA
GCGAATTTCGCCTTATTTATCTGATAAAACAATTTTAGTTAGTAATACATCAGGGCTAAGTATCAATAAGCTATGTGAGG
TATTACCTGCGCAGCATAGATCCAATTTTTGTGGAGTCCATTTTTTTAATCCACCGCGTTACATGCATTTGGCAGAACTA
ATTCCTGCCAATACTACATCATCTGATTTGCTCGATTATTTGGAAACATGGTTAACCGAGTATTTGGGCAAAGGAGTTGT
GAGAGCGAAAGACACTCCCAATTTTATCGCAAATCGAATAGGAGTCTTTTCACTATTAACTACCTTGCATCATACTTTAG
CCATGAATATGGGAATTGATGAAGTGGATGCCTTGACTGGTCCATTATTAGGAAGACCGAAATCTGCAACTTTTCGTACC
ATGGATGTGGTTGGTTTGGATACTATGCAACACGTTATTAATACCATGCAGTCTCAATTAACTGGTGATCCATGGCATAA
AATGTTTATTCTGCCGGACTGGTTGAATGGTTTAATTAAGGAAGGTCATTTAGGGCAAAAATCTGGCCAAGGAATTTACC
GAAAAGCAGGTAAAGTAATAGAAGTTTATGATATTCAAACCGGTCAATATAGACCCTCTCGAGCAGAAGTGAGTGATGAA
CTGAAAGCGATAATGGATATTAAAGATCCTGAAGCTCGAATGAAGAATTTAATGGCATCAAATAATAAGCAAGCTCAATT
TTTGTCGGCTTGCTTTAGAGATTTATTCCATTACTGTGCGTATCATTTGGAAGAAATTGCTGATAATGCAAGAGATGTTG
ATCTGGCAATTCGCTGGGGATTTGGATGGTCGCAAGGACCATTTGAAACTTGGCAGCTTTCTGATTTACACAGTGTGACT
CGACAAATCGATGAATCAATACAGGATAATACGGCATTATCAAGCGCAAAACTACCTGAGTGGTTATATGAAATAAAGGA
ATTTTACACACGAGAAGGCGCTTATTCGCCTGGTAAAAACAATTATCACGCCAGAAGTCAGTTACCTGTTTACCATAAAC
AATTCTTCCATGACAGGGTATTAAAGGAGTCACATCATCCTGTTCATGTTATTTATGAAAATGAGGGTGTTTGTTTGTGG
TACTTAAAAGATGATGTGGCTGTGATTAGTTTTAAAAGCAAAGCCAATACAATTGGTCAATCAGTTCTCGATGGCATAGA
GACTGCTTTGGATATCGCAGAAAGGGATTACCAGGGATTAATTATTTATCAACAAGATGCATCCAATTTTAGTTCAGGAG
CTGATCTACGTGGCGTCTCCAAATTATTAACAGATGGAACAATACAAGCTCTTGAGCATATGGTAGAGCAATTTCAACGG
GTAGCAATGCGGTTAAAATATAGTTCAATTCCAACTGTAGCTGCTTTAAGAGGTCGAGCATTAGGAGGTGGTTGTGAATT
AATGATGCATTGTGATTCTATTGTTGCTGCTTTTGAATCTTATCCCGGTTTAGTTGAGGCTGGAGTAGGAGTTATACCTG
CTGGTGGTGGTTGCAAAGAGCTCGCTATGCGTTCAGCACATCATGCCCAACAAGCTGATTTATTAACTTTTATATTGCCA
GTTTTTCAGCAAATAGCAACTGCAAAAGTAGCTGCAAGTGCGGTGGAAGCCAGAAATATGGGATATCTGCGTGCGGCTGA
TTCTATTCTAATGCATGCTGATGAGGTTTTATATGCCTCTTTAGAAAAAATCAAAGCCATGCGAGCTGCTAATTATCTTC
CTCCTATGAAAAAACAACGATTTAAAGTGGCAGGTATAGAGGGGCATGCCCGATTACAATCCGGTTTAGTGAATTGGTTG
GAAGGTGGATTTATATCACAGCATGATTATTTTCTGGCGAATGAATTGGCGAAAGTGTTGTGTGGTGGGGATGTCAATCA
TGGAACCTTGGTTGATGAACAATGGATGCTAAAGTTGGAAAGAGAAGCATTCATAAAACTAGCCAATACATCATTAACCC
AAGCCAGAATCAGTCATCTGTTAGAGACTGGTAAACCACTGCGCAACTAA

Upstream 100 bases:

>100_bases
TCAACAGATTATTGCTCCTTTTAGCCAATGGTAAGTGCCTGTTACCTGTAAATCTGACTCATAGAGGCATCAATCGATTA
TTAACAAGAGGATAATAACA

Downstream 100 bases:

>100_bases
GCAAGGAGAATTAGGATGACTGACGTATATGTAGTTGACGTATTACGTACACCAGTAGGTAAAGCACCAAGAGGTGTTTT
TAAAAACACATTACCTGATG

Product: 3-hydroxyacyl CoA dehydrogenase oxidoreductase protein/

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 789

Protein sequence:

>789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERVDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMASNNKQAQFLSACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQDNTALSSAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN

Sequences:

>Translated_789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERVDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMASNNKQAQFLSACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQDNTALSSAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN
>Mature_789_residues
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLKPTPLATPQTNELLQAKNYAE
NLEELSSCDLVIEAIAERVDWKEDLYKRISPYLSDKTILVSNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAEL
IPANTTSSDLLDYLETWLTEYLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVIEVYDIQTGQYRPSRAEVSDE
LKAIMDIKDPEARMKNLMASNNKQAQFLSACFRDLFHYCAYHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVT
RQIDESIQDNTALSSAKLPEWLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVSKLLTDGTIQALEHMVEQFQR
VAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFESYPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILP
VFQQIATAKVAASAVEARNMGYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHLLETGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=296, Percent_Identity=31.7567567567568, Blast_Score=124, Evalue=5e-28,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=30.6709265175719, Blast_Score=119, Evalue=2e-26,
Organism=Homo sapiens, GI20127408, Length=294, Percent_Identity=27.891156462585, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI68989263, Length=443, Percent_Identity=23.0248306997743, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI261878539, Length=443, Percent_Identity=23.0248306997743, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1787661, Length=327, Percent_Identity=28.4403669724771, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1790281, Length=207, Percent_Identity=28.9855072463768, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1788682, Length=250, Percent_Identity=26, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17549919, Length=300, Percent_Identity=30.3333333333333, Blast_Score=116, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=29.2517006802721, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17553560, Length=298, Percent_Identity=27.1812080536913, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17558304, Length=407, Percent_Identity=28.009828009828, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17508953, Length=419, Percent_Identity=27.2076372315036, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508951, Length=419, Percent_Identity=27.2076372315036, Blast_Score=103, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=295, Percent_Identity=31.1864406779661, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985923, Length=411, Percent_Identity=24.330900243309, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985930, Length=423, Percent_Identity=23.8770685579196, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19921000, Length=394, Percent_Identity=25.3807106598985, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24583077, Length=394, Percent_Identity=25.3807106598985, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583079, Length=394, Percent_Identity=25.3807106598985, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 87740; Mature: 87740

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLK
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PTPLATPQTNELLQAKNYAENLEELSSCDLVIEAIAERVDWKEDLYKRISPYLSDKTILV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
SNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAELIPANTTSSDLLDYLETWLTE
ECCCCCCHHHHHHHHCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
HHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVI
EHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
EVYDIQTGQYRPSRAEVSDELKAIMDIKDPEARMKNLMASNNKQAQFLSACFRDLFHYCA
EEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVTRQIDESIQDNTALSSAKLPE
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
WLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVS
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHH
KLLTDGTIQALEHMVEQFQRVAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFES
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILPVFQQIATAKVAASAVEARNM
CCCHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHHHHHHHH
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LETGKPLRN
HHCCCCCCC
>Mature Secondary Structure
MQEPFFIKKVAVLGAGVMGAQIAAHCVNAGIETLLFDLAGKEGPKNSLVDKAIANLGKLK
CCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
PTPLATPQTNELLQAKNYAENLEELSSCDLVIEAIAERVDWKEDLYKRISPYLSDKTILV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEE
SNTSGLSINKLCEVLPAQHRSNFCGVHFFNPPRYMHLAELIPANTTSSDLLDYLETWLTE
ECCCCCCHHHHHHHHCHHHCCCCCEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YLGKGVVRAKDTPNFIANRIGVFSLLTTLHHTLAMNMGIDEVDALTGPLLGRPKSATFRT
HHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEE
MDVVGLDTMQHVINTMQSQLTGDPWHKMFILPDWLNGLIKEGHLGQKSGQGIYRKAGKVI
EHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCEE
EVYDIQTGQYRPSRAEVSDELKAIMDIKDPEARMKNLMASNNKQAQFLSACFRDLFHYCA
EEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
YHLEEIADNARDVDLAIRWGFGWSQGPFETWQLSDLHSVTRQIDESIQDNTALSSAKLPE
HHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHH
WLYEIKEFYTREGAYSPGKNNYHARSQLPVYHKQFFHDRVLKESHHPVHVIYENEGVCLW
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEE
YLKDDVAVISFKSKANTIGQSVLDGIETALDIAERDYQGLIIYQQDASNFSSGADLRGVS
EEECCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHH
KLLTDGTIQALEHMVEQFQRVAMRLKYSSIPTVAALRGRALGGGCELMMHCDSIVAAFES
HHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YPGLVEAGVGVIPAGGGCKELAMRSAHHAQQADLLTFILPVFQQIATAKVAASAVEARNM
CCCHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GYLRAADSILMHADEVLYASLEKIKAMRAANYLPPMKKQRFKVAGIEGHARLQSGLVNWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEECCCHHHHHHHHHHHHH
EGGFISQHDYFLANELAKVLCGGDVNHGTLVDEQWMLKLEREAFIKLANTSLTQARISHL
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHH
LETGKPLRN
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]