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The map label for this gene is mdtL [H]

Identifier: 52841554

GI number: 52841554

Start: 1458245

End: 1459405

Strand: Reverse

Name: mdtL [H]

Synonym: lpg1323

Alternate gene names: 52841554

Gene position: 1459405-1458245 (Counterclockwise)

Preceding gene: 52841555

Following gene: 52841553

Centisome position: 42.95

GC content: 36.86

Gene sequence:

>1161_bases
ATGAAAAAAAATGCTCTTCTTATAGTGTTATTAACCTGGTTTCTTGGAAACATGGATATACATTTCCTTACTCCAGCCTT
GCCATCATTAGTTGATTACTTCTCGGTAACTCCCAATACAGTTCAACTAACTATCAGTCTTTTTCTTTTGGGAAAAGCCC
TCAGTATGATTTTATGGGGTCTTCTTTCCGAACGTTATGGAAGAAAACCAATCTTCATTGGAGGACTGTTGTTATTTATT
CTGAGCAATTTTCTGATTGCTCTAAACCACTCCATCCTTCCCTTTTTAGTATGCCGATTTCTCCAGGGAATTAGCGTAGG
CGCTACCCTTCTAATGGGTAGAGCAATGATTAACGATACCCATAATGAACAAAATGCCACAAAATACTTTGCGTGGTTAT
TTACTCTGGCTGGGCTGTTTATTTGCTTTCTTCCATTTTTTGGAGGTTTGATAAACAGTTATTGGAATTGGCAAATCGCC
TCTCTTATCATTGCTGCCTATGGCCTGCTTTTATTACCTTTATGTCGAGGTTTAAAAGAAACCAAACCCCATTATGTAAA
ATTCCCTCGCCTAGGTCATAGTATTATGGTGGTCTTCAACCATCCCCTTTTTGTTTCTTACCTCCTTATTTCTGCCTTGA
TGATGGCTGGAGAATCGGCGTTTAATACCAGCGCCTCTTTTATTCTTATTAAAGGAGAAAATTTTACCAGCGCTCAGTAT
GGTACAATCAAGACTACTATGGCAATTATGCATTTATTAGGTACCGCTTGTTGTGGCTTAATAGCAAAATATTATCATAG
TATCCAATTAACAAAATTAGGAGTACGTTTCTTTATTTTCGCAGCATTCTTGATGTGGTTATTTGTCTTTTCTGCTGAAA
ATATATATTTGACTTTTATAGTGCCTATGGTGATTTATTATTTTGGTACAGGTTTCATTGTTGCATCAGCAACAGCATCA
GCTGTTCGCCCTTTTCCTCAGCAAATGGCTCTTGCATTAGCTATCACTTTATTTTGTCAATTTAACTGCTCCGCTTTCTT
TAGTTTTATTACCAGCATGATAGGAATTCAGCAAGTAGAAACTTTTATGTTCTTATTAAGTTTGGTAAGTATTTTGAGTT
TTCTTGCCCTTCTAAAACTTCAACGAATGGAGCCCTGCTGA

Upstream 100 bases:

>100_bases
CCGGAATTTATAGTTTATTCGCGATTTTTGTTTACGGGTATGATCGGCTAAATGTCAGGCAGATGACAGATTTTTCCAAT
TCTTATTTTAACGTGAAATC

Downstream 100 bases:

>100_bases
AAAAACCATGATCTTTGATCCTGGTAAGAAAATATAAAGTTTGCGTGTATTTCTGCCTAAAGAAGACTATGCTTATTTAA
AATAAGTTCTTAATCGCATT

Product: drug resistance transporter, Bcr/CflA

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSVTPNTVQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILPFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQQMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVSILSFLALLKLQRMEPC

Sequences:

>Translated_386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSVTPNTVQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILPFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQQMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVSILSFLALLKLQRMEPC
>Mature_386_residues
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSVTPNTVQLTISLFLLGKALSMILWGLLSERYGRKPIFIGGLLLFI
LSNFLIALNHSILPFLVCRFLQGISVGATLLMGRAMINDTHNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIA
SLIIAAYGLLLLPLCRGLKETKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFIVPMVIYYFGTGFIVASATAS
AVRPFPQQMALALAITLFCQFNCSAFFSFITSMIGIQQVETFMFLLSLVSILSFLALLKLQRMEPC

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=348, Percent_Identity=25.8620689655172, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082312, Length=329, Percent_Identity=26.4437689969605, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790146, Length=368, Percent_Identity=23.6413043478261, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788509, Length=230, Percent_Identity=25.6521739130435, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787065, Length=239, Percent_Identity=25.5230125523013, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87081738, Length=93, Percent_Identity=37.6344086021505, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43272; Mature: 43272

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSVTPNTVQLTISLFLLGKALSMILWG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSERYGRKPIFIGGLLLFILSNFLIALNHSILPFLVCRFLQGISVGATLLMGRAMINDT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
HNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIASLIIAAYGLLLLPLCRGLKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHH
TKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
CCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VPMVIYYFGTGFIVASATASAVRPFPQQMALALAITLFCQFNCSAFFSFITSMIGIQQVE
HHHHHHHHCCHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TFMFLLSLVSILSFLALLKLQRMEPC
HHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKNALLIVLLTWFLGNMDIHFLTPALPSLVDYFSVTPNTVQLTISLFLLGKALSMILWG
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LLSERYGRKPIFIGGLLLFILSNFLIALNHSILPFLVCRFLQGISVGATLLMGRAMINDT
HHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
HNEQNATKYFAWLFTLAGLFICFLPFFGGLINSYWNWQIASLIIAAYGLLLLPLCRGLKE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCHHH
TKPHYVKFPRLGHSIMVVFNHPLFVSYLLISALMMAGESAFNTSASFILIKGENFTSAQY
CCCCEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
GTIKTTMAIMHLLGTACCGLIAKYYHSIQLTKLGVRFFIFAAFLMWLFVFSAENIYLTFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
VPMVIYYFGTGFIVASATASAVRPFPQQMALALAITLFCQFNCSAFFSFITSMIGIQQVE
HHHHHHHHCCHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TFMFLLSLVSILSFLALLKLQRMEPC
HHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]