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The map label for this gene is hisA

Identifier: 52841428

GI number: 52841428

Start: 1323571

End: 1324290

Strand: Reverse

Name: hisA

Synonym: lpg1195

Alternate gene names: 52841428

Gene position: 1324290-1323571 (Counterclockwise)

Preceding gene: 52841429

Following gene: 52841427

Centisome position: 38.98

GC content: 40.83

Gene sequence:

>720_bases
ATGTTAGTTATTCCAGCTATTGATTTGCAATCTGGACGATGTGTGCGCTTAAAACAAGGACGGTTTGATCAAGTAACGCA
ATTTAGCGTTTTTCCCATAGAAAGGGCTTTGCATTTTGCCAAACTAGGCGCCAAACGCCTTCACGTAGTCGATTTGGATG
GTGCTCGCAGCGGAAAAATGCAACAGTTGGAGCTCATTTGTTCCATGCAAAAGACAGGAATACCAATTCAAGCCGGAGGT
GGAATCAGGAGTATAGAACAAGCTTTGGAATGCAGCAACGCAGGAATTTCACAATTGGTCATTGGCAGCCTGGCTATTAC
AAATCCTGATTTGACAATACAAATCATTGAAAAGATTAAACCTGAAAATATTGTTCTTGCTCTGGACGTTCGTGTTGATA
CAAAAGTCCCCCTTCTTGCGATTAATGGCTGGCAAAATAATAGTACAAGCAGCCTTTGGGAAGTAGTGTCCTATTACGAA
AACTATGGGATAAAGAACATACTTTGTACTGACATCGCATGCGATGGCATGATGAATGGTCCTAATTTCGATTTGTATCA
ACAAGCAGTTGAATATTTTCCTCAGATTGCCTGGCAAGCCTCAGGGGGAGTACGCCATATGCAGGATATTACAACGCTGA
ATTCATTAGGAATATCCGCCGTAATCCTTGGGCTAATGCTTTATCAAGATCATATGAATTTAGAGGAATTATTATGTTAA

Upstream 100 bases:

>100_bases
TTGTAAAAAAAGGTAATTTTTATGGTATGCAATTTCATCCAGAAAAATCAGCCAATGTTGGCATGGTATTACTAAATAAC
TTTTTATCTTTGGAGTCTAC

Downstream 100 bases:

>100_bases
CGAAGCGAATCATTCCCTGTCTTGACGTTCGTGATAATCAGGTTGTCAAGGGAGTAAAATTTCGCAACCATAGAATAATT
GGAGAGATACTCCCTTTGGC

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQQLELICSMQKTGIPIQAGG
GIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIKPENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYE
NYGIKNILCTDIACDGMMNGPNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDHMNLEELLC

Sequences:

>Translated_239_residues
MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQQLELICSMQKTGIPIQAGG
GIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIKPENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYE
NYGIKNILCTDIACDGMMNGPNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDHMNLEELLC
>Mature_239_residues
MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKMQQLELICSMQKTGIPIQAGG
GIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIKPENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYE
NYGIKNILCTDIACDGMMNGPNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDHMNLEELLC

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=240, Percent_Identity=36.6666666666667, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1788336, Length=244, Percent_Identity=21.3114754098361, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26377; Mature: 26377

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKM
CEEEEEEECCCCCEEEECCCCCCCHHEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCH
QQLELICSMQKTGIPIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIK
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHEEECCCCEEEEEHHHCC
PENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYENYGIKNILCTDIACDGMMNG
CCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCC
PNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDHMNLEELLC
CCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHCC
>Mature Secondary Structure
MLVIPAIDLQSGRCVRLKQGRFDQVTQFSVFPIERALHFAKLGAKRLHVVDLDGARSGKM
CEEEEEEECCCCCEEEECCCCCCCHHEEEEHHHHHHHHHHHHCCCEEEEEECCCCCCCCH
QQLELICSMQKTGIPIQAGGGIRSIEQALECSNAGISQLVIGSLAITNPDLTIQIIEKIK
HHHHHHHHHHHCCCCEECCCCHHHHHHHHHHCCCCHHHHHHHHEEECCCCEEEEEHHHCC
PENIVLALDVRVDTKVPLLAINGWQNNSTSSLWEVVSYYENYGIKNILCTDIACDGMMNG
CCCEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCC
PNFDLYQQAVEYFPQIAWQASGGVRHMQDITTLNSLGISAVILGLMLYQDHMNLEELLC
CCHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA