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The map label for this gene is msrAB [H]

Identifier: 52841339

GI number: 52841339

Start: 1209124

End: 1209627

Strand: Direct

Name: msrAB [H]

Synonym: lpg1105

Alternate gene names: 52841339

Gene position: 1209124-1209627 (Clockwise)

Preceding gene: 52841337

Following gene: 52841344

Centisome position: 35.59

GC content: 36.51

Gene sequence:

>504_bases
ATGACAAAACTAATCAGCGTTGTATTTTATCTGTTTATAATTCCAAACGTGATGGCCTATACCCCTCAATTTAACAAATC
AGAGCAGCTTAAGAAGCTGACTCCATTGCAATATCAGGTAACCCAAAATGGAGCAACGGAAAAATCATTTGATAATGCAT
ACTGGAACAATAAAGAGGAAGGTATTTATGTTGATATAGTATCAGGAGAACCTTTGTTTAGTTCTAATGATAAATACGAT
TCAGGAACGGGTTGGCCCAGTTTTACAAAGCCAATCGATACATCCTATTTGGTTTTCCATACTGACAGAAGCTATTTTTT
TATTGTGCGTACTGAAGTTCGCTCTAAATACGCTAACTCTCATTTAGGCCATGTCTTTAAAGACGGGCCAGAACCAACCG
GGTTGCGATATTGCATGAATTCAGCTGCCTTGAAATTTATTCCAAAAAAAGAAATGGAACAAGCTGGGTATGGAGAGTAC
CTTTATCTGTTCAATAAAAAATAA

Upstream 100 bases:

>100_bases
ATTCCGATGGAAACGTAGATTTCTGATAATAGGGGTACGCTTGCTACACTATAAGTAAGTGTTATCAATGTGGGCATGAA
CAGTGAATGTGGAGTATGAC

Downstream 100 bases:

>100_bases
ACTGCCTTTGTTTTTCCAGCAAGTTAGCCTATGGAGTTCATTGAGCTCAAATCAATGTAGGAATAGAAATGAGCTGAACT
TGCCTTATGTTCCTAAGATT

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTKLISVVFYLFIIPNVMAYTPQFNKSEQLKKLTPLQYQVTQNGATEKSFDNAYWNNKEEGIYVDIVSGEPLFSSNDKYD
SGTGWPSFTKPIDTSYLVFHTDRSYFFIVRTEVRSKYANSHLGHVFKDGPEPTGLRYCMNSAALKFIPKKEMEQAGYGEY
LYLFNKK

Sequences:

>Translated_167_residues
MTKLISVVFYLFIIPNVMAYTPQFNKSEQLKKLTPLQYQVTQNGATEKSFDNAYWNNKEEGIYVDIVSGEPLFSSNDKYD
SGTGWPSFTKPIDTSYLVFHTDRSYFFIVRTEVRSKYANSHLGHVFKDGPEPTGLRYCMNSAALKFIPKKEMEQAGYGEY
LYLFNKK
>Mature_166_residues
TKLISVVFYLFIIPNVMAYTPQFNKSEQLKKLTPLQYQVTQNGATEKSFDNAYWNNKEEGIYVDIVSGEPLFSSNDKYDS
GTGWPSFTKPIDTSYLVFHTDRSYFFIVRTEVRSKYANSHLGHVFKDGPEPTGLRYCMNSAALKFIPKKEMEQAGYGEYL
YLFNKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=125, Percent_Identity=50.4, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI301336162, Length=125, Percent_Identity=50.4, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI73089054, Length=125, Percent_Identity=50.4, Blast_Score=134, Evalue=4e-32,
Organism=Homo sapiens, GI37620216, Length=125, Percent_Identity=50.4, Blast_Score=133, Evalue=7e-32,
Organism=Homo sapiens, GI117606353, Length=137, Percent_Identity=48.9051094890511, Blast_Score=122, Evalue=1e-28,
Organism=Escherichia coli, GI1788077, Length=138, Percent_Identity=44.2028985507246, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI115532676, Length=131, Percent_Identity=38.9312977099237, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17553450, Length=131, Percent_Identity=38.9312977099237, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319816, Length=120, Percent_Identity=35.8333333333333, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553335, Length=124, Percent_Identity=50, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356369, Length=124, Percent_Identity=50, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24645799, Length=123, Percent_Identity=50.4065040650407, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221378664, Length=123, Percent_Identity=48.780487804878, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24645804, Length=135, Percent_Identity=46.6666666666667, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24645801, Length=134, Percent_Identity=47.0149253731343, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=45.8015267175573, Blast_Score=127, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 19312; Mature: 19181

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLISVVFYLFIIPNVMAYTPQFNKSEQLKKLTPLQYQVTQNGATEKSFDNAYWNNKEE
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCC
GIYVDIVSGEPLFSSNDKYDSGTGWPSFTKPIDTSYLVFHTDRSYFFIVRTEVRSKYANS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEHHHHHHHCC
HLGHVFKDGPEPTGLRYCMNSAALKFIPKKEMEQAGYGEYLYLFNKK
CCCHHHCCCCCCCHHHHHHHHHHHEECCHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure 
TKLISVVFYLFIIPNVMAYTPQFNKSEQLKKLTPLQYQVTQNGATEKSFDNAYWNNKEE
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCC
GIYVDIVSGEPLFSSNDKYDSGTGWPSFTKPIDTSYLVFHTDRSYFFIVRTEVRSKYANS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEEHHHHHHHCC
HLGHVFKDGPEPTGLRYCMNSAALKFIPKKEMEQAGYGEYLYLFNKK
CCCHHHCCCCCCCHHHHHHHHHHHEECCHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]