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The map label for this gene is appB [H]

Identifier: 52841195

GI number: 52841195

Start: 1048112

End: 1049089

Strand: Direct

Name: appB [H]

Synonym: lpg0960

Alternate gene names: 52841195

Gene position: 1048112-1049089 (Clockwise)

Preceding gene: 52841194

Following gene: 52841196

Centisome position: 30.85

GC content: 36.91

Gene sequence:

>978_bases
ATGATTAAATACATACTCCGCAGAATTTTATATGCGATTCCAATTTTGTTTGGTATTAATCTTATTACTTTTGCATTGTT
TTTCATGGTTAATTCTCCCGATGATATGGCACGTATGCACTTGGGTAATAAACATGTAGAGCAAAAAGCCATTGAAGATT
GGAAAGTGGTTCATGGCTATGATTTACCGTTATTTTATAATGAAAAGCAGACTGGATTTAATCAATTTAGACAGACTTTG
TTTTATCAAAAATCGCTGATGTTGTTTACATTTAATTTTGGTGTCTCGGATGCTGGTAGAGATATTAGCCACGATATATC
CTACAGAATGTGGCCAAGCCTTGCCATTGCCCTGCCAACATTATTATTTGCTGTTTTGGTGAATATCATTTTTGCTATGG
CTATGGCATTTTTCCGTTCGACTTATCTTGATTTATCCGGGGTAGTTATTTGTATTATCCTAATGTCCATTTCCAGTTTG
TTTTACATCATTGGCGGGCAATATCTGTTTGGAAAAATATTAAAATGGTTCCCTATTTCCGGCTACGATGATGGCCTCGA
TGCTTTAAAATTTACTATTTTACCAGTCCTGGTAGCTGTTCTGGGACAATTGGGTGCGGGAGCGCGTTGGTATCGAACCT
TGGTTTTGGAAGAAATTAATAAAGATTATGTAAAAACCGCAAGAGCAAAGGGGCTCTCTGAGCAAAGGATTTTATTTAAG
CATATATTAAAAAATGCCATGTTACCCATTTTGACCGGAATTGTTGTAATCATTCCTACTTTGTTTATGGGAAGTTTGGT
TTTAGAGTCTTTTTTTGGTGTGCCAGGCCTGGGTAGCTATATTATTGATGCGATACAACAGCAAGATTTTGCTATTGTAC
GAGCTATGGTATTTCTGGGGTCAGTTCTTTACATCATAGGCTTGGTTCTGACTGATTTTTCTTACATCCTAGTTGATCCC
CGAGTGCGATTATCCTGA

Upstream 100 bases:

>100_bases
CTTTAGGTGTGCTGTTTGGCCTATTGATTGCTCTGGTAATCCCTTTATTGATTACTTATTTAAAGAAAGAAAAACAGCCG
GCAGAAAGAGTAAAATTAAA

Downstream 100 bases:

>100_bases
TAACCAAGGAGTATGAGGCAAAAATGACATTTGAATTGCTTTGGACTGACAAATGTTTTCTTACTTTACTGGCGGTGGTT
TTATTTACCGTTCTGCTGAG

Product: peptide ABC transporter, permease protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIKYILRRILYAIPILFGINLITFALFFMVNSPDDMARMHLGNKHVEQKAIEDWKVVHGYDLPLFYNEKQTGFNQFRQTL
FYQKSLMLFTFNFGVSDAGRDISHDISYRMWPSLAIALPTLLFAVLVNIIFAMAMAFFRSTYLDLSGVVICIILMSISSL
FYIIGGQYLFGKILKWFPISGYDDGLDALKFTILPVLVAVLGQLGAGARWYRTLVLEEINKDYVKTARAKGLSEQRILFK
HILKNAMLPILTGIVVIIPTLFMGSLVLESFFGVPGLGSYIIDAIQQQDFAIVRAMVFLGSVLYIIGLVLTDFSYILVDP
RVRLS

Sequences:

>Translated_325_residues
MIKYILRRILYAIPILFGINLITFALFFMVNSPDDMARMHLGNKHVEQKAIEDWKVVHGYDLPLFYNEKQTGFNQFRQTL
FYQKSLMLFTFNFGVSDAGRDISHDISYRMWPSLAIALPTLLFAVLVNIIFAMAMAFFRSTYLDLSGVVICIILMSISSL
FYIIGGQYLFGKILKWFPISGYDDGLDALKFTILPVLVAVLGQLGAGARWYRTLVLEEINKDYVKTARAKGLSEQRILFK
HILKNAMLPILTGIVVIIPTLFMGSLVLESFFGVPGLGSYIIDAIQQQDFAIVRAMVFLGSVLYIIGLVLTDFSYILVDP
RVRLS
>Mature_325_residues
MIKYILRRILYAIPILFGINLITFALFFMVNSPDDMARMHLGNKHVEQKAIEDWKVVHGYDLPLFYNEKQTGFNQFRQTL
FYQKSLMLFTFNFGVSDAGRDISHDISYRMWPSLAIALPTLLFAVLVNIIFAMAMAFFRSTYLDLSGVVICIILMSISSL
FYIIGGQYLFGKILKWFPISGYDDGLDALKFTILPVLVAVLGQLGAGARWYRTLVLEEINKDYVKTARAKGLSEQRILFK
HILKNAMLPILTGIVVIIPTLFMGSLVLESFFGVPGLGSYIIDAIQQQDFAIVRAMVFLGSVLYIIGLVLTDFSYILVDP
RVRLS

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=351, Percent_Identity=29.0598290598291, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1787053, Length=324, Percent_Identity=26.8518518518519, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787497, Length=332, Percent_Identity=28.6144578313253, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789888, Length=324, Percent_Identity=25, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1788504, Length=364, Percent_Identity=27.7472527472527, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787761, Length=345, Percent_Identity=27.2463768115942, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1787550, Length=263, Percent_Identity=26.9961977186312, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 36850; Mature: 36850

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKYILRRILYAIPILFGINLITFALFFMVNSPDDMARMHLGNKHVEQKAIEDWKVVHGY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCC
DLPLFYNEKQTGFNQFRQTLFYQKSLMLFTFNFGVSDAGRDISHDISYRMWPSLAIALPT
CCCEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHH
LLFAVLVNIIFAMAMAFFRSTYLDLSGVVICIILMSISSLFYIIGGQYLFGKILKWFPIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GYDDGLDALKFTILPVLVAVLGQLGAGARWYRTLVLEEINKDYVKTARAKGLSEQRILFK
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HILKNAMLPILTGIVVIIPTLFMGSLVLESFFGVPGLGSYIIDAIQQQDFAIVRAMVFLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVLYIIGLVLTDFSYILVDPRVRLS
HHHHHHHHHHHCCHHEEECCCCCCC
>Mature Secondary Structure
MIKYILRRILYAIPILFGINLITFALFFMVNSPDDMARMHLGNKHVEQKAIEDWKVVHGY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCC
DLPLFYNEKQTGFNQFRQTLFYQKSLMLFTFNFGVSDAGRDISHDISYRMWPSLAIALPT
CCCEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHCCCHHHHHHHHHHHHH
LLFAVLVNIIFAMAMAFFRSTYLDLSGVVICIILMSISSLFYIIGGQYLFGKILKWFPIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCC
GYDDGLDALKFTILPVLVAVLGQLGAGARWYRTLVLEEINKDYVKTARAKGLSEQRILFK
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
HILKNAMLPILTGIVVIIPTLFMGSLVLESFFGVPGLGSYIIDAIQQQDFAIVRAMVFLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SVLYIIGLVLTDFSYILVDPRVRLS
HHHHHHHHHHHCCHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]