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The map label for this gene is kmo [H]

Identifier: 52841127

GI number: 52841127

Start: 966773

End: 968122

Strand: Direct

Name: kmo [H]

Synonym: lpg0892

Alternate gene names: 52841127

Gene position: 966773-968122 (Clockwise)

Preceding gene: 52841126

Following gene: 52841128

Centisome position: 28.45

GC content: 36.67

Gene sequence:

>1350_bases
ATGAAGCACATTACCATAATTGGAGCCGGGTTAGCGGGAACTTTGTGTGGTTTATATCTTGCTAGAAGAGGCTATGAAGT
AGAGTTGTTTGAATCAAGACCAGACATTCGTAATAGTCCGACTGATTATGGACGCTCCATTAATCTTGCTTTGTCATGCA
GAGGAATTACCGCTTTAAAAGCAATGAACCTGTTAAGTGAAGTAAATAAAATTATGGTTCCAATGCGGGCAAGAGCTATT
CACGAAGCCAATGGCGAGGTTCACTATCAACCATTTGGACGTTACATTGATGAATATATCAATGCTATTTCTCGTTCTGA
TCTCAATGCCTTGCTTTTAAATAAAGCGGAATTATGCCCTAACATTAAATTACACTTTAATATGAAATTGCACTCTCTTG
ATATTCATAATAAAAAAATTAAATTTGAAAATAAAAATGGTGATTTTGTTGAGGCCTCATATCATAGACTAATTGGAGCA
GATGGTGCGCCGTCTCATGTAAGGGATATGCTGAAAAATGAAGGGATAGTTAGTGCAAGCAGAGATTTTTTATCTCATGG
ATACAAGGAGCTTTCAATTAGCAAAAAACATACAAAAGGGATGGCTAGGGAGCATTTGCATTTATGGCCACGTGATTCGT
TTATGCTATTAGGTAATCCTAATCCTGACGATTCAATTACAGGTTCTTTGTTTTTAGCTAATGAAGGGAAAGACAGCTTT
GCTGAACTAAATAATGAAGAAAAATTACATTTATTTTTTAAAACACAGTTCCCGGATGCCTATGCAGCTATGCCAAATTT
GGTCCAAGAATTTTTTGGTAATCCTACTGGACATTTGAGTACTATCCAATGCTCACCCTGGTACTATAAAGACGAATGCT
TATTAATAGGTGATGCGGCACATGGGATAATTCCATTCTTTGGGCAAGGAATGAATAGCGCATTTGAAGATTGCCGTATT
CTTGATGAATTACTGGATGAATACCAAGACGACTGGTCGCGAGTGAACCCTCTTTTTTATGAACAAAGAAAAGTGAATAC
CGATGCGATAGCGAAAATGTCCATGGATAATTATCATGAGATTCATTCGGACATAAGAAATCCAAAATTTATTTTACAAA
AGCAGATTGAACGGGAACTCATGTTGCGATACCCGGAACATTATGTTTCCATGCATGTTTTGGTTATGTTTACCAATACC
CCGTATGCTAAAGCGATGGCAATAGGCGAGTTACAATCTGGCCTTTTAGAGCAAATTTGTTTCCCAATAACTGATATTAA
GGAGTTAAATTGGCAGGAAGTAGAGAAATTACTTGGCATATATGACAAAAAATTGGCGAAAATTATTTGA

Upstream 100 bases:

>100_bases
GTTTTACTTTTATTCAAGCAATATATTGATTGAATTTGTGTATTTTTTAAGGAGATTCGGAATAGATGTCGTGTTGATAT
AGAATGGGTTGGGAGGATAA

Downstream 100 bases:

>100_bases
TTTAATTTATGTCATTCATTTTAAATGAAATTTATAGTCAAAGTTTTGTCAGAAAAGATGGATTCAGGGACATTTTTTTG
TCGCTACCTGAGGGTTATTA

Product: kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRYIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNPLFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLGIYDKKLAKII

Sequences:

>Translated_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRYIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNPLFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLGIYDKKLAKII
>Mature_449_residues
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALKAMNLLSEVNKIMVPMRARAI
HEANGEVHYQPFGRYIDEYINAISRSDLNALLLNKAELCPNIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGA
DGAPSHVRDMLKNEGIVSASRDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAAHGIIPFFGQGMNSAFEDCRI
LDELLDEYQDDWSRVNPLFYEQRKVNTDAIAKMSMDNYHEIHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNT
PYAKAMAIGELQSGLLEQICFPITDIKELNWQEVEKLLGIYDKKLAKII

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=423, Percent_Identity=36.8794326241135, Blast_Score=287, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17562934, Length=443, Percent_Identity=31.8284424379233, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI212646493, Length=353, Percent_Identity=30.3116147308782, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193208447, Length=310, Percent_Identity=30.3225806451613, Blast_Score=140, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319372, Length=435, Percent_Identity=31.4942528735632, Blast_Score=202, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28573964, Length=422, Percent_Identity=36.0189573459716, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 51333; Mature: 51333

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEVHYQPFGRYIDEYINAISRSDLNALLLNKAELCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHCHHHHCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CCEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVNPLFYEQRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLGIYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKHITIIGAGLAGTLCGLYLARRGYEVELFESRPDIRNSPTDYGRSINLALSCRGITALK
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEEEECCHHHHH
AMNLLSEVNKIMVPMRARAIHEANGEVHYQPFGRYIDEYINAISRSDLNALLLNKAELCP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHCHHHHCC
NIKLHFNMKLHSLDIHNKKIKFENKNGDFVEASYHRLIGADGAPSHVRDMLKNEGIVSAS
CCEEEEEEEEEEEECCCCEEEEECCCCCEEEHHHHHHHCCCCCHHHHHHHHHCCCCCHHH
RDFLSHGYKELSISKKHTKGMAREHLHLWPRDSFMLLGNPNPDDSITGSLFLANEGKDSF
HHHHHCCCHHHCCCHHHHHHHHHHHCEECCCCCEEEECCCCCCCCCCEEEEEECCCCHHH
AELNNEEKLHLFFKTQFPDAYAAMPNLVQEFFGNPTGHLSTIQCSPWYYKDECLLIGDAA
HHCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCEECCCEEEEECCC
HGIIPFFGQGMNSAFEDCRILDELLDEYQDDWSRVNPLFYEQRKVNTDAIAKMSMDNYHE
CCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHCCHHHHH
IHSDIRNPKFILQKQIERELMLRYPEHYVSMHVLVMFTNTPYAKAMAIGELQSGLLEQIC
HHHHHCCCHHHHHHHHHHHHHHHCCHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHH
FPITDIKELNWQEVEKLLGIYDKKLAKII
CCCCCHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA